Review
Oncology
Kaipeng Jin, Chao Qian, Jinti Lin, Bing Liu
Summary: COX-2 and PGE2 play important roles in chronic inflammatory diseases, increasing tumor incidence and promoting tumor growth and metastasis. The COX-2-PGE2 pathway affects tumor-associated immune cells and promotes tumor immune evasion.
FRONTIERS IN ONCOLOGY
(2023)
Review
Psychiatry
Ying He, Yuanshan Han, Xiaolin Liao, Manshu Zou, Yuhong Wang
Summary: This paper summarizes the relationship between COX-2 and depression in terms of neuroinflammation, intestinal flora, neurotransmitters, HPA axis, mitochondrial dysfunction, and hippocampal neuronal damage. It provides a reference for further research on the prevention, clinical treatment, and scientific understanding of depression.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Pharmacology & Pharmacy
Zhiran Ju, Menglan Li, Junde Xu, Daniel C. Howell, Zhiyun Li, Fen-Er Chen
Summary: Cyclooxygenases play a vital role in inflammation, but currently used anti-inflammatory drugs have associated adverse effects. Researchers are searching for novel selective COX-2 inhibitors.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Pharmacology & Pharmacy
Jiawei Wang, Xiangjun Kong, Linfeng Hu, Yuanjia Hu
Summary: This article provides a comprehensive review of patents related to dry powder inhalers (DPIs), including disease indications, medicaments, milestone patents, and small molecule inhibitors. The study identifies popular technologies in the DPI field and explores emerging development directions to assist researchers in making relevant R&D decisions.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Health Care Sciences & Services
Mario Alberto Isiordia-Espinoza, Eduardo Gomez-Sanchez, Itzel Joselyn Mora-Falcon, Ivan Agustin Amador-Beas, Adriana Hernandez-Gomez, Nicolas Addiel Serafin-Higuera, Lorenzo Franco-de la Torre
Summary: The objective of this systematic review and meta-analysis was to evaluate the analgesic efficacy of COX-2 inhibitors versus other drugs in periodontal surgery. The data analysis showed that COX-2 inhibitors reduced the consumption of rescue analgesics and lower pain intensity compared to placebo and other drugs after periodontal surgery.
Article
Biochemistry & Molecular Biology
Mohamed M. S. Hamoud, Nermine A. Osman, Samar Rezq, Hend A. A. Abd El-wahab, Abdalla E. A. Hassan, Hanan A. Abdel-Fattah, Damian G. Romero, Amany M. Ghanim
Summary: By synthesizing and evaluating two series of 1,3,4-oxadiazole and 1,2,4-triazole derivatives, this study discovered their potential anti-inflammatory and antioxidant activity, highlighting them as potential novel therapeutic agents for inflammation and oxidative stress-related diseases.
BIOORGANIC CHEMISTRY
(2022)
Article
Veterinary Sciences
Jianzhong Wang, Jingyuan Kong, Yuxin Yang, Yu Liu, Jicheng Qiu, Xiaohui Gong, Lu Zhang, Jing Li, Feifei Sun, Xingyuan Cao
Summary: This study investigated the absorption, tissue distribution, excretion, and metabolism of vitacoxib in Wistar rats. Vitacoxib was well distributed in most tissues within 15 minutes and could cross the intestinal barrier. It was mainly eliminated as two metabolites, with the carboxylic acid derivative being the major metabolite excreted in urine and feces. The proposed metabolic pathways involved hydroxylation and oxidation reactions. Vitacoxib displayed high AUC(last) and long half-life in rats, indicating its potential as an effective nonsteroidal anti-inflammatory agent.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Victor Albarran, Jesus Chamorro, Diana Isabel Rosero, Cristina Saavedra, Ainara Soria, Alfredo Carrato, Pablo Gajate
Summary: Immune checkpoint inhibitors have revolutionized the treatment of multiple malignant diseases, but their systemic activity may lead to a wide range of immune-related side effects. Neurotoxicity, although less frequent, is of particular importance due to its potential severity and impact on cancer treatment. Further research is needed to better understand the pathogenesis and develop effective treatment strategies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nada H. El-Dershaby, Soad A. El-Hawash, Shaymaa E. Kassab, Hoda G. Dabees, Ahmed E. Abdel Moneim, Ibrahim A. Abdel Wahab, Mohammad M. Abd-Alhaseeb, Mostafa M. M. El-Miligy
Summary: A new series of co-drugs were designed for the treatment of septicaemia, with compound 5j demonstrating potent COX-2 inhibition and broad-spectrum antibacterial activity.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Aaftaab Sethi, Swetha Sanam, Ravi Alvala, Mallika Alvala
Summary: Galectins, especially galectin-1 and galectin-3, have shown high therapeutic potential in various diseases. While carbohydrate-based inhibitors have been successful, recent research on heterocyclic-based inhibitors may provide easier synthesis and better specificity in developing efficient galectin inhibitors.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2021)
Review
Oncology
Mohammad Mahboubi-Rabbani, Maryam Abbasi, Afshin Zarghi
Summary: Cyclooxygenase-2 (COX-2) is an important enzyme in cancer development and a target of interest for drug designers. However, prolonged use of COX-2 inhibitors is associated with life-threatening cardiovascular side effects. This review explores the potential of natural secondary metabolites as COX-2 inhibitors and their ability to inhibit cancer development.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Review
Oncology
Mohammad Mahboubi-Rabbani, Maryam Abbasi, Afshin Zarghi
Summary: Cyclooxygenase-2 (COX-2) is an enzyme that plays a crucial role in cancer development. However, prolonged use of COX-2 inhibitors may have life-threatening cardiovascular side effects. By modifying the structures of natural secondary metabolites, COX-2 selective inhibitors with limited side effects and comparative efficacy can be developed. Therefore, researchers are exploring natural organic scaffolds as leads for new COX-2 inhibitors.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yara El-Dash, Nadia A. Khalil, Eman M. Ahmed, Marwa S. A. Hassan
Summary: Two novel series of compounds derived from nicotinic acid were synthesized and evaluated for their inhibitory activity against COX-1 and COX-2, showing high potency and selectivity towards COX-2 inhibition. The most potent compound exhibited strong in vivo anti-inflammatory activity and potential influence on inflammatory cytokines, suggesting promising anti-inflammatory properties. Molecular docking studies further supported their remarkable COX-2 inhibitory activity compared to celecoxib.
BIOORGANIC CHEMISTRY
(2021)
Review
Immunology
Yue Shen, Xiangkai Meng, Lili Wang, Xiaoxiao Wang, Hua Chang
Summary: This case report describes a rare case of a patient with primary advanced vaginal carcinoma combined with cervical adenocarcinoma. The patient underwent personalized treatment and showed improvement, achieving complete remission.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Medicinal
Ali Aliabadi, Elham Khanniri, Mohammad Mahboubi-Rabbani, Maryam Bayanati
Summary: Dual cyclooxygenase 2/15-lipoxygenase inhibitors offer a valuable alternative for the treatment of inflammatory diseases and prevention of cancer, with reduced side effects compared to classical NSAIDs and selective COX-2 inhibitors. This review provides an overview of the COX-2 and 15-LOX pathways and discusses various structural families of dual inhibitors, paving the way for the design of potentially-active anticancer agents with balanced dual inhibition of these enzymes.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Markus Laube, Cemena Gassner, Sai Kiran Sharma, Robert Guenther, Arne Pigorsch, Jonas Koenig, Martin Koeckerling, Frank Wuest, Jens Pietzsch, Torsten Kniese
JOURNAL OF ORGANIC CHEMISTRY
(2015)
Article
Chemistry, Physical
Baker Jawabrah Al-Hourani, Musa I. El-Barghouthi, Robert McDonald, Wajdy Al-Awaida, Sai Kiran Sharma, Frank Wuest
JOURNAL OF MOLECULAR STRUCTURE
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sai Kiran Sharma, Kuntal K. Sevak, Sebastien Monette, Sean D. Carlin, James C. Knight, Frank R. Wuest, Evis Sale, Brian M. Zeglis, Jason S. Lewis
JOURNAL OF NUCLEAR MEDICINE
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sai Kiran Sharma, Brandon Nemieboka, Evis Sala, Jason S. Lewis, Brian M. Zeglis
JOURNAL OF NUCLEAR MEDICINE
(2016)
Review
Radiology, Nuclear Medicine & Medical Imaging
Pierre Adumeau, Sai Kiran Sharma, Colleen Brent, Brian M. Zeglis
MOLECULAR IMAGING AND BIOLOGY
(2016)
Review
Radiology, Nuclear Medicine & Medical Imaging
Pierre Adumeau, Sai Kiran Sharma, Colleen Brent, Brian M. Zeglis
MOLECULAR IMAGING AND BIOLOGY
(2016)
Review
Biochemical Research Methods
Lukas M. Carter, Sophie Poty, Sai Kiran Sharma, Jason S. Lewis
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2018)
Article
Biochemical Research Methods
Delphine Vivier, Sai Kiran Sharma, Brian M. Zeglis
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2018)
Article
Chemistry, Medicinal
Baker Jawabrah Al-Hourani, Sai Kiran Sharma, Jatinder Kaur, Frank Wuest
MEDICINAL CHEMISTRY RESEARCH
(2015)
Article
Chemistry, Organic
Ole Tietz, Sai Kiran Sharma, Jatinder Kaur, Jenilee Way, Alison Marshall, Melinda Wuest, Frank Wuest
ORGANIC & BIOMOLECULAR CHEMISTRY
(2013)
Article
Biochemical Research Methods
Sai Kiran Sharma, Mavanur R. Suresh, Frank R. Wuest
PROTEIN EXPRESSION AND PURIFICATION
(2014)
Article
Chemistry, Multidisciplinary
Markus Laube, Christoph Tondera, Sai Kiran Sharma, Nicole Bechmann, Franz-Jacob Pietzsch, Arne Pigorsch, Martin Koeckerling, Frank Wuest, Jens Pietzsch, Torsten Kniess
Article
Radiology, Nuclear Medicine & Medical Imaging
Sai Kiran Sharma, Melinda Wuest, Monica Wang, Darryl Glubrecht, Bonnie Andrais, Suzanne E. Lapi, Frank Wuest
Article
Radiology, Nuclear Medicine & Medical Imaging
Sai Kiran Sharma, Maya Suzuki, Hong Xu, Joshua A. Korsen, Zachary Samuels, Hongfen Guo, Brandon Nemieboka, Alessandra Piersigilli, Kimberly J. Edwards, Nai-Kong Cheung, Jason S. Lewis
Summary: Immuno-PET is a powerful tool for studying the biodistribution of antibodies in vivo. This study used radiolabeled HuE71 IgG1 and IgG4 antibodies with the same variable heavy- and light-chain sequences but different Fc portions to investigate their in vivo biodistribution in SKOV3 ovarian cancer xenografted nude mice. The results highlight the influence of Fc modifications and the choice of IgG subclass on the biodistribution of antibodies.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Melinda Wuest, Manuela Kuchar, Sai Kiran Sharma, Susan Richter, Ingrit Hamann, Monica Wang, Larissa Vos, John R. Mackey, Frank Wuest, Reik Loeser
BREAST CANCER RESEARCH
(2015)