Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years

Green synthesis of therapeutically active 1,3,4-oxadiazoles as antioxidants, selective COX-2 inhibitors and their in silico studies

(2021) Aravind R. Nesaragi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Quinolizidine alkaloids from Sophora alopecuroides with anti-inflammatory and anti-tumor properties

(2021) Jian-Chun Li et al.   BIOORGANIC CHEMISTRY

Phenolic Compounds from Carissa spinarum Are Characterized by Their Antioxidant, Anti-Inflammatory and Hepatoprotective Activities

(2021) Ye Liu et al.   Antioxidants

Discovery of pyrazole N-aryl sulfonate: A novel and highly potent cyclooxygenase-2 (COX-2) selective inhibitors

(2021) Haiyan Yao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives bearing 1,3-thiazole moiety as novel anti-inflammatory EGFR inhibitors with cardiac safety profile

(2021) Salah A. Abdel-Aziz et al.   BIOORGANIC CHEMISTRY

Therapeutic potential of isobavachalcone, a natural flavonoid, in murine experimental colitis by inhibiting NF‐κB p65

(2021) Yishan Zhou et al.   PHYTOTHERAPY RESEARCH

Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold

(2020) Tarek S. Ibrahim et al.   BIOORGANIC CHEMISTRY

Periplanetols A−F, phenolic compounds from Periplaneta americana with potent COX-2 inhibitory activity

(2020) Hong-Fu Bai et al.   FITOTERAPIA

Anti-rheumatoid arthritis effects of flavonoids from Daphne genkwa

(2020) Yue-wen Sun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Costunolide inhibits inflammation in LPS-induced RAW264.7 cells and ameliorates gastric acid reflux-induced esophageal injury in rat model

(2020) Li Nan et al.   Applied Biological Chemistry

Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective

(2020) Samik Bindu et al.   BIOCHEMICAL PHARMACOLOGY

Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety

(2020) Begüm Nurpelin Sağlık et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The binding of kaempferol-3-O-rutinoside to vascular endothelial growth factor potentiates anti-inflammatory efficiencies in lipopolysaccharide-treated mouse macrophage RAW264.7 cells

(2020) Wei-Hui Hu et al.   PHYTOMEDICINE

Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: Anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies

(2020) Abdallah M. Alfayomy et al.   BIOORGANIC CHEMISTRY

Design, Synthesis and Comprehensive Investigations of Pyrrolo[3,4-d]pyridazinone-Based 1,3,4-Oxadiazole as New Class of Selective COX-2 Inhibitors

(2020) Łukasz Szczukowski et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural modification of indomethacin toward selective inhibition of COX-2 with a significant increase in van der Waals contributions

(2019) Akari Ikeda et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ligand based design and synthesis of pyrazole based derivatives as selective COX-2 inhibitors

(2019) Manikanta Murahari et al.   BIOORGANIC CHEMISTRY

New cyathane diterpenoids with neurotrophic and anti-neuroinflammatory activity from the bird's nest fungus Cyathus africanus

(2019) Xia Yin et al.   FITOTERAPIA

Anti-neuroinflammatory and antioxidant phenylpropanoids from Chinese olive

(2019) Shujuan Zhang et al.   FOOD CHEMISTRY

New phenolic cinnamic acid derivatives as selective COX-2 inhibitors. Design, synthesis, biological activity and structure-activity relationships

(2019) Daniela Ribeiro et al.   BIOORGANIC CHEMISTRY

Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids

(2019) Hajjaj H.M. Abdu-Allah et al.   BIOORGANIC CHEMISTRY

New imidazolone derivatives comprising a benzoate or sulfonamide moiety as anti-inflammatory and antibacterial inhibitors: Design, synthesis, selective COX-2, DHFR and molecular-modeling study

(2019) Nadia Hanafy Metwally et al.   BIOORGANIC CHEMISTRY

Design of balanced COX inhibitors based on anti-inflammatory and/or COX-2 inhibitory ascidian metabolites

(2019) Zhiran Ju et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies

(2019) Nehad A. El-Sayed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multiple In vitro biological effects of phenolic compounds from Morus alba root bark

(2019) Marie Čulenová et al.   JOURNAL OF ETHNOPHARMACOLOGY

Synthesis, biological evaluation and docking study of a new series of di-substituted benzoxazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents

(2018) Avneet Kaur et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, Biological Evaluation and Docking Study of N -(2-(3,4,5-Trimethoxybenzyl)Benzoxazole-5-yl) Benzamide Derivatives as Selective COX-2 Inhibitor and Anti-inflammatory Agents

(2018) Avneet Kaur et al.   BIOORGANIC CHEMISTRY

Sesquiterpene Lactones with COX-2 Inhibition Activity from Artemisia lavandulaefolia

(2018) Jie-Li Lü et al.   CHEMISTRY & BIODIVERSITY

New selective cyclooxygenase-2 inhibitors from cyclocoumarol: Synthesis, characterization, biological evaluation and molecular modeling

(2018) Anita Marie Rayar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Investigation of constituents from Cinnamomum camphora (L.) J. Presl and evaluation of their anti-inflammatory properties in lipopolysaccharide-stimulated RAW 264.7 macrophages

(2018) Yan-Ru Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Indole Derivatives as Cyclooxygenase Inhibitors: Synthesis, Biological Evaluation and Docking Studies

(2018) Mashooq Bhat et al.   MOLECULES

Triterpenoid saponins and flavonoids from licorice residues with anti-inflammatory activity

(2018) Ming Bai et al.   INDUSTRIAL CROPS AND PRODUCTS

Differential regulation of MyD88- and TRIF-dependent signaling pathways of Toll-like receptors by cardamonin

(2018) Ah-Yeon Kim et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Isolation of Novel Sesquiterpeniods and Anti-neuroinflammatory Metabolites from Nardostachys jatamansi

(2018) Chi-Su Yoon et al.   MOLECULES

Discovery of anti-inflammatory terpenoids from Mallotus conspurcatus croizat

(2018) Yanjun Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Antioxidant and anti-inflammatory properties of flavonoids from lotus plumule

(2018) Gui-Lin Chen et al.   FOOD CHEMISTRY

Non-Clinical Studies for Evaluation of 8-C-Rhamnosyl Apigenin Purified from Peperomia obtusifolia against Acute Edema

(2017) Cinthia Tamayose et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis

(2017) Zuzana Hanáková et al.   JOURNAL OF NATURAL PRODUCTS

Phenylpropanoids from Lilium Asiatic hybrid flowers and their anti-inflammatory activities

(2017) Nhan Nguyen Thi et al.   Applied Biological Chemistry

Synthesis, characterization and pharmacological evaluation of pyrazolyl urea derivatives as potential anti-inflammatory agents

(2017) Kanagasabai Somakala et al.   Acta Pharmaceutica Sinica B

Synthesis of phenylpiperazine derivatives of 1,4-benzodioxan as selective COX-2 inhibitors and anti-inflammatory agents

(2016) Juan Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure–activity relationship of novel series of 1,5-disubstituted tetrazoles as cyclooxygenase-2 inhibitors: Design, synthesis, bioassay screening and molecular docking studies

(2016) Baker Jawabrah Al-Hourani et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel N -substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study

(2016) Phoebe F. Lamie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR

(2016) Eman K.A. Abdelall et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Coptisine Prevented IL-β-Induced Expression of Inflammatory Mediators in Chondrocytes

(2016) Kai Zhou et al.   INFLAMMATION

Isolates of Alpinia officinarum Hance as COX-2 inhibitors: Evidence from anti-inflammatory, antioxidant and molecular docking studies

(2016) Varsha S. Honmore et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Design, synthesis and biological evaluation of 1,3,4-oxadiazoles as promising anti-inflammatory agents

(2016) Vishwanathan Balasubramanya Iyer et al.   MEDICINAL CHEMISTRY RESEARCH

Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis

(2016) Chongshan Dai et al.   MOLECULAR NEUROBIOLOGY

Screening of ferulic acid related compounds as inhibitors of xanthine oxidase and cyclooxygenase-2 with anti-inflammatory activity

(2016) Shivraj Hariram Nile et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Phloroglucinol and Terpenoid Derivatives from Hypericum cistifolium and H. galioides (Hypericaceae)

(2016) Sara L. Crockett et al.   Frontiers in Plant Science

Screening of ferulic acid related compounds as inhibitors of xanthine oxidase and cyclooxygenase-2 with anti-inflammatory activity

(2016) Shivraj Hariram Nile et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Design, synthesis, biological evaluation and molecular modeling of dihydropyrazole sulfonamide derivatives as potential COX-1/COX-2 inhibitors

(2015) Zhong Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes

(2015) Palwinder Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Characterization of Phenolic Compounds and Antioxidant and Anti-inflammatory Activities from Mamuyo (Styrax ramirezii Greenm.) Fruit

(2015) Michael A. Timmers et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibitory Effects of 4′-Demethylnobiletin, a Metabolite of Nobiletin, on 12-O-Tetradecanoylphorbol-13-acetate (TPA)-Induced Inflammation in Mouse Ears

(2015) Xian Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anti-inflammatory Activity of Saxifragin via Inhibition of NF-κB Involves Caspase-1 Activation

(2015) Se-Yun Cheon et al.   JOURNAL OF NATURAL PRODUCTS

New phenyl derivatives from endophytic fungusBotryosphaeriasp. SCSIO KcF6 derived of mangrove plantKandelia candel

(2015) Zhi-ran Ju et al.   NATURAL PRODUCT RESEARCH

2,5-Diaryl-1,3,4-oxadiazoles as selective COX-2 inhibitors and anti-inflammatory agents

(2015) Jagdeep Grover et al.   RSC Advances

Design and Synthesis of Benzimidazole Analogs Endowed with Oxadiazole as Selective COX-2 Inhibitor

(2014) Ankita Rathore et al.   ARCHIV DER PHARMAZIE

Synthesis, biological evaluation and molecular modeling study of pyrazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents

(2014) Ashish Kumar Tewari et al.   BIOORGANIC CHEMISTRY

Synthesis, Molecular Docking, and Biological Evaluation of Some Novel Hydrazones and Pyrazole Derivatives as Anti-inflammatory Agents

(2014) Khaled O. Mohammed et al.   Chemical Biology & Drug Design

Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism

(2014) Carmen B. Rödl et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core

(2014) Pakornwit Sarnpitak et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Celecoxib analogs bearing benzofuran moiety as cyclooxygenase-2 inhibitors: Design, synthesis and evaluation as potential anti-inflammatory agents

(2014) Ghaneya Sayed Hassan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity

(2014) Sumit Bansal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

N-(3-Arylaminopyridin-4-yl)alkanesulfonamides as pyridine analogs of nimesulide: Cyclooxygenases inhibition, anti-inflammatory studies and insight on metabolism

(2014) Jean-François Renard et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Puerarin ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney through ERK/Nrf2/ARE pathway

(2014) Jie-Qiong Ma et al.   FOOD AND CHEMICAL TOXICOLOGY

Piperine Inhibits the Activities of Platelet Cytosolic Phospholipase A2 and Thromboxane A2 Synthase without Affecting Cyclooxygenase-1 Activity: Different Mechanisms of Action Are Involved in the Inhibition of Platelet Aggregation and Macrophage Inflammatory Response

(2014) Dong Son et al.   Nutrients

Flavonoid constituents in the leaves of Myrica rubra sieb. et zucc. with anti-inflammatory activity

(2013) Han Hyuk Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Synthesis of novel celecoxib analogues by bioisosteric replacement of sulfonamide as potent anti-inflammatory agents and cyclooxygenase inhibitors

(2013) Nisha Chandna et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthetic Approaches towards the Sulfonamide Substituted-1,5-Diarylimidazole-2-thiones as Selective Cyclooxygense-2 inhibitors

(2013) Latifeh Navidpour et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Prenylated and Geranylated Flavonoids Increase Production of Reactive Oxygen Species in Mouse Macrophages but Inhibit the Inflammatory Response

(2013) Jan Hošek et al.   JOURNAL OF NATURAL PRODUCTS

Rotenoids from Boerhaavia diffusa as Potential Anti-inflammatory Agents

(2013) Khemraj Bairwa et al.   JOURNAL OF NATURAL PRODUCTS

Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis

(2013) Yu-Fang Lin et al.   MOLECULES

COX-2 inhibitory activity of homoisoflavanones and xanthones from the bulbs of the Southern African Ledebouria socialis and Ledebouria ovatifolia (Hyacinthaceae: Hyacinthoideae)

(2013) Catherine P. Waller et al.   PHYTOCHEMISTRY

Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2

(2012) Magda A.-A. El-Sayed et al.   BIOORGANIC & MEDICINAL CHEMISTRY

N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: Synthesis and biological evaluation

(2012) Jatinder Kaur et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Caffeoyl serotonin as selective COX-2 inhibitor

(2012) Toshiyuki Takahashi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Indole based cyclooxygenase inhibitors: Synthesis, biological evaluation, docking and NMR screening

(2012) Mónica S. Estevão et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure–activity relationship for anti-inflammatory drug

(2012) Shigeo Hayashi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-inflammatory properties of anthraquinones and their relationship with the regulation of P-glycoprotein function and expression

(2012) Ran Joo Choi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study

(2011) Magda A.-A. El-Sayed et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Oleanane-type triterpene saponins from the bark of Aralia elata and their NF-κB inhibition and PPAR activation signal pathway

(2011) Nguyen Xuan Nhiem et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of 1,5-diaryl-substituted tetrazoles as novel selective cyclooxygenase-2 (COX-2) inhibitors

(2011) Baker Jawabrah Al-Hourani et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tormentic acid, a triterpenoid saponin, isolated from Rosa rugosa, inhibited LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophages

(2011) Hyo-Jin An et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Lycorine inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in RAW264.7 cells through suppressing P38 and STATs activation and increases the survival rate of mice after LPS challenge

(2011) Jingjing Kang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Berberine ameliorates COX-2 expression in rat small intestinal mucosa partially through PPARγ pathway during acute endotoxemia

(2011) Ai-Wen Feng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Recent Advances in the Synthesis of 2-Imidazolines and Their Applications in Homogeneous Catalysis

(2009) Han Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

The search for new COX-2 inhibitors: a review of 2002 – 2008 patents

(2009) Teodorico C Ramalho et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Exploration of physicochemical properties and molecular modelling studies of 2-sulfonyl-phenyl-3-phenyl-indole analogs as cyclooxygenase-2 inhibitors

(2007) Arun Kumar Gupta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY