Stem cell-based therapies for osteoarthritis

Biomimetics of the extracellular matrix: an integrated three-dimensional fiber-hydrogel composite for cartilage tissue engineering

(2013) Jeannine Coburn et al.   Smart Structures and Systems

High mesenchymal stem cell seeding densities in hyaluronic acid hydrogels produce engineered cartilage with native tissue properties

(2012) Isaac E. Erickson et al.   Acta Biomaterialia

Simultaneous regeneration of articular cartilage and subchondral bone induced by spatially presented TGF-beta and BMP-4 in a bilayer affinity binding system

(2012) Tali Re’em et al.   Acta Biomaterialia

Musculoskeletal tissue engineering by endogenous stem/progenitor cells

(2012) Hemin Nie et al.   CELL AND TISSUE RESEARCH

Ovine synovial membrane-derived mesenchymal progenitor cells retain the phenotype of the original tissue that was exposed to in-vivo inflammation: evidence for a suppressed chondrogenic differentiation potential of the cells

(2012) Wataru Ando et al.   INFLAMMATION RESEARCH

New insights into cartilage repair — The role of migratory progenitor cells in osteoarthritis

(2012) Regina Gerter et al.   MATRIX BIOLOGY

Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen

(2012) M. Horie et al.   OSTEOARTHRITIS AND CARTILAGE

Mesenchymal stem cells secrete factors that inhibit inflammatory processes in short-term osteoarthritic synovium and cartilage explant culture

(2012) G.M. van Buul et al.   OSTEOARTHRITIS AND CARTILAGE

Bioinspired nanofibers support chondrogenesis for articular cartilage repair

(2012) J. M. Coburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Stem Cell-Based Approach to Cartilage Repair

(2012) K. Johnson et al.   SCIENCE

A Comparison of the Functionality and In Vivo Phenotypic Stability of Cartilaginous Tissues Engineered from Different Stem Cell Sources

(2012) Tatiana Vinardell et al.   TISSUE ENGINEERING PART A

Hypoxia Impedes Hypertrophic Chondrogenesis of Human Multipotent Stromal Cells

(2012) Debby Gawlitta et al.   TISSUE ENGINEERING PART A

Isolation and Phenotypic Characterisation of Stem Cells from Late Stage Osteoarthritic Mesenchymal Tissues

(2012) Luminita Labusca et al.   Current Stem Cell Research & Therapy

Generation of human induced pluripotent stem cells from osteoarthritis patient-derived synovial cells

(2011) Min-Jeong Kim et al.   ARTHRITIS AND RHEUMATISM

Induction of chondrogenic cells from dermal fibroblast culture by defined factors does not involve a pluripotent state

(2011) Hidetatsu Outani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxygen tension regulates the osteogenic, chondrogenic and endochondral phenotype of bone marrow derived mesenchymal stem cells

(2011) Eamon J. Sheehy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Simultaneous regeneration of articular cartilage and subchondral bone in vivo using MSCs induced by a spatially controlled gene delivery system in bilayered integrated scaffolds

(2011) Jiangning Chen et al.   BIOMATERIALS

Homing and reparative effect of intra-articular injection of autologus mesenchymal stem cells in osteoarthritic animal model

(2011) Abir N Mokbel et al.   BMC MUSCULOSKELETAL DISORDERS

Inflammation in osteoarthritis

(2011) Mary B. Goldring et al.   CURRENT OPINION IN RHEUMATOLOGY

Obesity short-circuits stemness gene network in human adipose multipotent stem cells

(2011) Mar Roldan et al.   FASEB JOURNAL

Chondrogenesis by chemotactic homing of synovium, bone marrow, and adipose stem cells in vitro

(2011) Avital Mendelson et al.   FASEB JOURNAL

Osteochondral interface regeneration of the rabbit knee with macroscopic gradients of bioactive signals

(2011) Nathan H. Dormer et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Cartilage oligomeric matrix protein enhances matrix assembly during chondrogenesis of human mesenchymal stem cells

(2011) Hana Haleem-Smith et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors

(2011) Kunihiko Hiramatsu et al.   JOURNAL OF CLINICAL INVESTIGATION

Human mesenchymal stem cells in synovial fluid increase in the knee with degenerated cartilage and osteoarthritis

(2011) Ichiro Sekiya et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation

(2011) Darwin J Prockop et al.   MOLECULAR THERAPY

Synovial fluid CD34− CD44+ CD90+ mesenchymal stem cell levels are associated with the severity of primary knee osteoarthritis

(2011) D.-H. Lee et al.   OSTEOARTHRITIS AND CARTILAGE

Reduced Reactivation from Dormancy but Maintained Lineage Choice of Human Mesenchymal Stem Cells with Donor Age

(2011) Verena Dexheimer et al.   PLoS One

Catabolic Factors and Osteoarthritis-Conditioned Medium Inhibit Chondrogenesis of Human Mesenchymal Stem Cells

(2011) Genoveva T.H. Heldens et al.   TISSUE ENGINEERING PART A

Chondrogenic differentiation in femoral bone marrow-derived mesenchymal cells (MSC) from elderly patients suffering osteoarthritis or femoral fracture

(2010) Felícito García-Álvarez et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study

(2010) Chang H Lee et al.   LANCET

Multifunctional Hybrid Three-dimensionally Woven Scaffolds for Cartilage Tissue Engineering

(2010) Franklin T. Moutos et al.   MACROMOLECULAR BIOSCIENCE

Migratory Chondrogenic Progenitor Cells from Repair Tissue during the Later Stages of Human Osteoarthritis

(2009) Sebastian Koelling et al.   Cell Stem Cell

A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study of Intravenous Adult Human Mesenchymal Stem Cells (Prochymal) After Acute Myocardial Infarction

(2009) Joshua M. Hare et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY