siRNA-based therapeutic approaches for rheumatic diseases

Safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of the monoclonal antibody ASK8007 blocking osteopontin in patients with rheumatoid arthritis: a randomised, placebo controlled, proof-of-concept study

(2011) M J H Boumans et al.   ANNALS OF THE RHEUMATIC DISEASES

Gene Therapy for Rheumatoid Arthritis

(2011) Sylvie Fabre et al.   BIODRUGS

Anionic polymers for decreased toxicity and enhanced in vivo delivery of siRNA complexed with cationic liposomes

(2011) Anne Schlegel et al.   JOURNAL OF CONTROLLED RELEASE

Effective reduction of the interleukin-1β transcript in osteoarthritis-prone guinea pig chondrocytes via short hairpin RNA mediated RNA interference influences gene expression of mediators implicated in disease pathogenesis

(2011) K.S. Santangelo et al.   OSTEOARTHRITIS AND CARTILAGE

Adeno-associated virus type 5-mediated intraarticular administration of tumor necrosis factor small interfering RNA improves collagen-induced arthritis

(2010) Maroun Khoury et al.   ARTHRITIS AND RHEUMATISM

Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses

(2010) Jeroen N. Stoop et al.   ARTHRITIS AND RHEUMATISM

Cytosolic phospholipase A2α gene silencing in the myeloid lineage alters development of Th1 responses and reduces disease severity in collagen-induced arthritis

(2010) G. Courties et al.   ARTHRITIS AND RHEUMATISM

In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cells

(2010) G. Courties et al.   BLOOD

Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis

(2010) C-R Wang et al.   GENE THERAPY

Intra-articular Microparticles for Drug Delivery to the TMJ

(2010) P.M. Mountziaris et al.   JOURNAL OF DENTAL RESEARCH

Treatment of Autoimmune Arthritis Using RNA Interference-Modulated Dendritic Cells

(2010) X. Zheng et al.   JOURNAL OF IMMUNOLOGY

RNAi-mediated CD40-CD154 interruption promotes tolerance in autoimmune arthritis

(2010) Xiufen Zheng et al.   ARTHRITIS RESEARCH & THERAPY

Small interfering RNA targeting CD81 ameliorated arthritis in rats

(2009) Shuji Nakagawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse

(2009) M Takanashi et al.   GENE THERAPY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

Monocyte Scintigraphy in Rheumatoid Arthritis: The Dynamics of Monocyte Migration in Immune-Mediated Inflammatory Disease

(2009) Rogier M. Thurlings et al.   PLoS One

Efficient suppression of murine arthritis by combined anticytokine small interfering RNA lipoplexes

(2008) Maroun Khoury et al.   ARTHRITIS AND RHEUMATISM

Comparison of anti-rheumatic effects of local RNAi-based therapy in collagen induced arthritis rats using various cytokine genes as molecular targets

(2008) Atsuo Inoue et al.   Modern Rheumatology

Chitosan/siRNA Nanoparticle–mediated TNF-α Knockdown in Peritoneal Macrophages for Anti-inflammatory Treatment in a Murine Arthritis Model

(2008) Kenneth A Howard et al.   MOLECULAR THERAPY

Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis

(2008) Q. Lai Kwan Lam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi

(2008) J. L. McBride et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-κBp65-specific siRNA

(2007) L.X. Chen et al.   OSTEOARTHRITIS AND CARTILAGE