Natural polyphenols in the management of major depression

Protection of Apigenin against Kainate-Induced Excitotoxicity by Anti-oxidative Effects

(2015) Jin-Yi Han et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Influence of long-term administration of rutin on spatial memory as well as the concentration of brain neurotransmitters in aged rats

(2014) Justyna Pyrzanowska et al.   Pharmacological Reports

Antidepressant-like activity of ellagic acid in unstressed and acute immobilization-induced stressed mice

(2014) Dinesh Dhingra et al.   Pharmacological Reports

Quercetin supplementation: insight into the potentially harmful outcomes of neurodegenerative prevention

(2013) Maja Jazvinšćak Jembrek et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Natural polyphenols against neurodegenerative disorders: Potentials and pitfalls

(2012) Azadeh Ebrahimi et al.   AGEING RESEARCH REVIEWS

Antidepressant-like effects of curcumin in WKY rat model of depression is associated with an increase in hippocampal BDNF

(2012) Laura L. Hurley et al.   BEHAVIOURAL BRAIN RESEARCH

Polymethoxyflavones as agents that prevent formation of cataract: Nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells

(2012) Yoshiki Miyata et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Influence of Quercetin-Rich Food Intake on microRNA Expression in Lung Cancer Tissues

(2012) T. K. Lam et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Drug interaction potential of resveratrol

(2012) Pascal Detampel et al.   DRUG METABOLISM REVIEWS

Ferulic acid exerts antidepressant-like effect in the tail suspension test in mice: Evidence for the involvement of the serotonergic system

(2012) Ana Lúcia B. Zeni et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Evidence for the involvement of the monoaminergic system, but not the opioid system in the antidepressant-like activity of ellagic acid in mice

(2012) Chandrashekaran Girish et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Kappa-opioid receptors mediate the antidepressant-like activity of hesperidin in the mouse forced swimming test

(2012) Carlos B. Filho et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Resveratrol promotes neurotrophic factor release from astroglia

(2012) Feng Zhang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Curcumin and neurodegenerative diseases: a perspective

(2012) Altaf S Darvesh et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

In vitro cytogenetic and genotoxic effects of curcumin on human peripheral blood lymphocytes

(2012) Natividad Sebastià et al.   FOOD AND CHEMICAL TOXICOLOGY

Evaluation of the Inhibitory Effects of Quercetin-Related Flavonoids and Tea Catechins on the Monoamine Oxidase-A Reaction in Mouse Brain Mitochondria

(2012) Yauhen Bandaruk et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Resveratrol Inhibits the Proliferation of Neural Progenitor Cells and Hippocampal Neurogenesis

(2012) Hee Ra Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment

(2012) J. Wang et al.   JOURNAL OF NEUROSCIENCE

Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice

(2012) Young-Sil Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type

(2012) H. Javed et al.   NEUROSCIENCE

Antimetastatic effect of nobiletin through the down-regulation of CXC chemokine receptor type 4 and matrix metallopeptidase-9

(2012) Seung Ho Baek et al.   PHARMACEUTICAL BIOLOGY

Antidepressant and anxiolytic effects of amentoflavone isolated from Cnestis ferruginea in mice

(2012) Ismail O. Ishola et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

NMDA GluN2B receptors involved in the antidepressant effects of curcumin in the forced swim test

(2012) Lin Zhang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Evidence for the involvement of the serotonergic 5-HT1A receptors in the antidepressant-like effect caused by hesperidin in mice

(2012) Leandro C. Souza et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Treatment-resistant depression: therapeutic trends, challenges, and future directions

(2012) Al-harbi   Patient Preference and Adherence

Chlorogenic Acid Improves Neuroprotective Effect of PEP-1-Ribosomal Protein S3 Against Ischemic Insult

(2012) Eun Hee Ahn et al.   Experimental Neurobiology

The antidepressant-like effect of fisetin involves the serotonergic and noradrenergic system

(2011) Linlin Zhen et al.   BEHAVIOURAL BRAIN RESEARCH

Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke

(2011) Syed Shadab Raza et al.   BRAIN RESEARCH

Ferulic acid-induced anti-depression and prokinetics similar to Chaihu–Shugan–San via polypharmacology

(2011) Ying-jin Zhang et al.   BRAIN RESEARCH BULLETIN

Citrus Flavonoids Luteolin, Apigenin, and Quercetin Inhibit Glycogen Synthase Kinase-3β Enzymatic Activity by Lowering the Interaction Energy Within the Binding Cavity

(2011) Jodee L. Johnson et al.   JOURNAL OF MEDICINAL FOOD

Development of High-Energy Amorphous Solid Dispersion of Nanosized Nobiletin, a Citrus Polymethoxylated Flavone, with Improved Oral Bioavailability

(2011) Satomi Onoue et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Hesperidin, a Flavone Glycoside, as Mediator of Neuronal Survival

(2011) Jader Nones et al.   NEUROCHEMICAL RESEARCH

Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats

(2011) Ertugrul Uzar et al.   NEUROLOGICAL SCIENCES

Involvement of estrogen receptors in the resveratrol-mediated increase in dopamine transporter in human dopaminergic neurons and in striatum of female mice

(2011) Valentina Di Liberto et al.   NEUROPHARMACOLOGY

Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats

(2011) Zhen Huang et al.   NEUROSCIENCE LETTERS

Effect of quercetin and glucuronide metabolites on the monoamine oxidase-A reaction in mouse brain mitochondria

(2011) Saki Yoshino et al.   NUTRITION

Gastroprotective and antidepressant effects of a new zinc(II)–curcumin complex in rodent models of gastric ulcer and depression induced by stresses

(2011) Xueting Mei et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Chronic Intraperitoneal and Oral Treatments with Hesperidin Induce Central Nervous System Effects in Mice

(2011) Cristina Wasowski et al.   PHYTOTHERAPY RESEARCH

Proanthocyanidins Inhibit Iron Absorption from Soybean (Glycine max) Seed Ferritin in Rats with Iron Deficiency Anemia

(2011) Shaojun Yun et al.   PLANT FOODS FOR HUMAN NUTRITION

Curcumin inhibits glutamate release in nerve terminals from rat prefrontal cortex: Possible relevance to its antidepressant mechanism

(2011) Tzu Yu Lin et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Curcumin ameliorates reserpine-induced pain–depression dyad: Behavioural, biochemical, neurochemical and molecular evidences

(2011) V. Arora et al.   PSYCHONEUROENDOCRINOLOGY

Does coffee enriched with chlorogenic acids improve mood and cognition after acute administration in healthy elderly? A pilot study

(2011) Vanessa Cropley et al.   PSYCHOPHARMACOLOGY

Antidepressant-like effect of chlorogenic acid isolated fromArtemisia capillarisThunb.

(2010) Soo-Hyun Park et al.   Animal Cells and Systems

Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK

(2010) Katarzyna Zygmunt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice

(2010) Young-Sil Lee et al.   BIOCHEMICAL PHARMACOLOGY

Anti-neuroinflammatory Activity of Nobiletin on Suppression of Microglial Activation

(2010) Yanji Cui et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice

(2010) Seung-Hwan Kwon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antidepressant-like effect of trans-resveratrol: Involvement of serotonin and noradrenaline system

(2010) Ying Xu et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease

(2010) Pamela Maher et al.   HUMAN MOLECULAR GENETICS

An overview of curcumin in neurological disorders

(2010) SK Kulkarni et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Dietary inhibitors of monoamine oxidase A

(2010) Sarah E. Dixon Clarke et al.   JOURNAL OF NEURAL TRANSMISSION

Protective Effects of Grape Seed Proanthocyanidin Extracts on Cerebral Cortex of Streptozotocin-Induced Diabetic Rats through Modulating AGEs/RAGE/NF-κB Pathway

(2010) Mei LU et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

The Effect of Minor Constituents of Olive Oil on Cardiovascular Disease: New Findings

(2010) Francesco Visioli et al.   NUTRITION REVIEWS

Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin

(2010) Li-Tao Yi et al.   PHYSIOLOGY & BEHAVIOR

Reversal by quercetin of corticotrophin releasing factor induced anxiety- and depression-like effect in mice

(2010) Pravinkumar Bhutada et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Involvement of monoaminergic system in the antidepressant-like effect of the flavonoid naringenin in mice

(2010) Li-Tao Yi et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Behavioral animal models of depression

(2010) Hua-Cheng Yan et al.   Neuroscience Bulletin

Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation

(2009) Yui Yamamoto et al.   BRAIN RESEARCH

A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding

(2009) Nathan R. Perron et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Flavonoid quercetin protects against swimming stress-induced changes in oxidative biomarkers in the hypothalamus of rats

(2009) Nagaraja Haleagrahara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Current investigational drugs for major depression

(2009) Shrinivas K Kulkarni et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Anti-inflammatory activity of naringin and the biosynthesised naringenin by naringinase immobilized in microstructured materials in a model of DSS-induced colitis in mice

(2009) Maria Inês Amaro et al.   FOOD RESEARCH INTERNATIONAL

Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin

(2009) Pamela Maher   Genes and Nutrition

Roasted Coffees High in Lipophilic Antioxidants and Chlorogenic Acid Lactones Are More Neuroprotective than Green Coffees

(2009) Yi-Fang Chu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary-adrenal axis response in Wistar rats

(2009) Kyuichi Kawabata et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Ferulic acid induces neural progenitor cell proliferation in vitro and in vivo

(2009) T. Yabe et al.   NEUROSCIENCE

Antidepressant-like effect of low molecular proanthocyanidin in mice: Involvement of monoaminergic system

(2009) Ying Xu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Pharmacological Exploration of the Sedative Mechanism of Hesperidin Identified as the Active Principle ofCitrus sinensisFlowers

(2009) Silvia Guzmán-Gutiérrez et al.   PLANTA MEDICA

Red Wine Polyphenols Prevent Metabolic and Cardiovascular Alterations Associated with Obesity in Zucker Fatty Rats (Fa/Fa)

(2009) Abdelali Agouni et al.   PLoS One

Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats

(2009) Yu-Cheng Li et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons

(2009) Rui Wang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The flavonoid fisetin promotes nerve cell survival from trophic factor withdrawal by enhancement of proteasome activity

(2008) Pamela Maher   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Antinociceptive Effects of St. John's Wort, Harpagophytum Procumbens Extract and Grape Seed Proanthocyanidins Extract in Mice

(2008) Shinya Uchida et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Antidepressant-Like Effect of Onion (Allium cepaL.) Powder in a Rat Behavioral Model of Depression

(2008) Hiroyuki SAKAKIBARA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB

(2008) Rui Wang et al.   BRAIN RESEARCH

Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: Evidence for the involvement of the serotonergic and noradrenergic systems

(2008) Daniele G. Machado et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Drug development for liver diseases: focus on picroliv, ellagic acid and curcumin

(2008) C. Girish et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity

(2008) Long Tai Zheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Isolation of the MAO-inhibitor naringenin from Mentha aquatica L.

(2008) Helle T. Olsen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression

(2008) Kavon Rezai-Zadeh et al.   Journal of Neuroinflammation

Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical apigenin

(2008) Li-Tao Yi et al.   LIFE SCIENCES

Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid β protein

(2008) Tatsuhiro Akaishi et al.   NEUROSCIENCE LETTERS

Antidepressant activity of curcumin: involvement of serotonin and dopamine system

(2008) Shrinivas K. Kulkarni et al.   PSYCHOPHARMACOLOGY

Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus

(2007) Kentaro Matsuzaki et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors

(2007) Rui Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY