Tailored tools to improve pharmacotherapy in infants

Changes in Individual Drug-Independent System Parameters during Virtual Paediatric Pharmacokinetic Trials: Introducing Time-Varying Physiology into a Paediatric PBPK Model

(2014) Khaled Abduljalil et al.   AAPS Journal

Evidence-Based Morphine Dosing for Postoperative Neonates and Infants

(2014) Elke H. J. Krekels et al.   CLINICAL PHARMACOKINETICS

Methods for pharmacokinetic analysis in young children

(2014) Adam S Himebauch et al.   Expert Opinion on Drug Metabolism & Toxicology

Population pharmacokinetic modelling of total and unbound cefazolin plasma concentrations as a guide for dosing in preterm and term neonates

(2014) R. F. W. De Cock et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Optimal Oxygenation of Extremely Low Birth Weight Infants: A Meta-Analysis and Systematic Review of the Oxygen Saturation Target Studies

(2014) Ola Didrik Saugstad et al.   Neonatology

Administration of a Probiotic Can Change Drug Pharmacokinetics: Effect of E. coli Nissle 1917 on Amidarone Absorption in Rats

(2014) Zuzana Matuskova et al.   PLoS One

Strategic Biomarkers for Drug Development in Treating Rare Diseases and Diseases in Neonates and Infants

(2013) Jane P. F. Bai et al.   AAPS Journal

The allometric exponent for scaling clearance varies with age: a study on seven propofol datasets ranging from preterm neonates to adults

(2013) Chenguang Wang et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Approaches for dosage individualisation in critically ill patients

(2013) M a del Mar Fernández de Gatta et al.   Expert Opinion on Drug Metabolism & Toxicology

Association of OPRM1 and COMT Single-Nucleotide Polymorphisms With Hospital Length of Stay and Treatment of Neonatal Abstinence Syndrome

(2013) Elisha M. Wachman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Age Related Changes in Fractional Elimination Pathways for Drugs: Assessing the Impact of Variable Ontogeny on Metabolic Drug-Drug Interactions

(2013) Farzaneh Salem et al.   JOURNAL OF CLINICAL PHARMACOLOGY

A Neonatal Amikacin Covariate Model Can Be Used to Predict Ontogeny of Other Drugs Eliminated Through Glomerular Filtration in Neonates

(2013) Roosmarijn F. W. De Cock et al.   PHARMACEUTICAL RESEARCH

A Clinical Tool for Reducing Central Nervous System Depression among Neonates Exposed to Codeine through Breast Milk

(2013) Lauren E. Kelly et al.   PLoS One

Newborns, One of the Last Therapeutic Orphans to Be Adopted

(2013) Justin L. Stiers et al.   JAMA Pediatrics

Drug Labeling and Exposure in Neonates

(2013) Matthew M. Laughon et al.   JAMA Pediatrics

Augmented Renal Clearance in the Critically Ill: How to Assess Kidney Function

(2012) Veerle Grootaert et al.   ANNALS OF PHARMACOTHERAPY

Long-term child follow-up after large obstetric randomised controlled trials for the evaluation of perinatal interventions: a systematic review of the literature

(2012) MJ Teune et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Pharmacokinetics and pharmacodynamics of medication in asphyxiated newborns during controlled hypothermia. The PharmaCool multicenter study

(2012) Timo R de Haan et al.   BMC Pediatrics

External evaluation of population pharmacokinetic models of vancomycin in neonates: the transferability of published models to different clinical settings

(2012) Wei Zhao et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetics and Clinical Efficacy of Phenobarbital in Asphyxiated Newborns Treated with Hypothermia

(2012) M. P. H. van den Broek et al.   CLINICAL PHARMACOKINETICS

Maturation of the Glomerular Filtration Rate in Neonates, as Reflected by Amikacin Clearance

(2012) Roosmarijn F.W. De Cock et al.   CLINICAL PHARMACOKINETICS

Pharmacokinetics of Drugs in Neonates: Pattern Recognition Beyond Compound Specific Observations

(2012) Anne Smits et al.   CURRENT PHARMACEUTICAL DESIGN

Educational paper: Do we need neonatal clinical pharmacologists?

(2012) Karel Allegaert et al.   EUROPEAN JOURNAL OF PEDIATRICS

Developmental expression of drug metabolizing enzymes: Impact on disposition in neonates and young children

(2012) R.N. Hines   INTERNATIONAL JOURNAL OF PHARMACEUTICS

An Algorithm to Detect Adverse Drug Reactions in the Neonatal Intensive Care Unit

(2012) Wei Du et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Creatinine reference values in ELBW infants: impact of quantification by Jaffe or enzymatic method

(2012) Karel Allegaert et al.   Journal of Maternal-Fetal & Neonatal Medicine

The Impact of Extracorporeal Life Support and Hypothermia on Drug Disposition in Critically Ill Infants and Children

(2012) Enno D. Wildschut et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Effect of hypothermia and extracorporeal life support on drug disposition in neonates

(2012) Enno D. Wildschut et al.   Seminars in Fetal & Neonatal Medicine

Critical Illness Is a Major Determinant of Midazolam Clearance in Children Aged 1 Month to 17 Years

(2012) Ibrahim Ince et al.   THERAPEUTIC DRUG MONITORING

Tolerability and Outcomes of Kinetically Guided Therapy With Gentamicin in Critically Ill Neonates During the First Week of Life: An Open-Label, Prospective Study

(2011) Jirina Martínková et al.   CLINICAL THERAPEUTICS

Drug policy in Europe

(2011) Evelyne Jacqz-Aigrain   EARLY HUMAN DEVELOPMENT

Neonatal drug development

(2011) Mark A. Turner   EARLY HUMAN DEVELOPMENT

Profound changes in drug metabolism enzymes and possible effects on drug therapy in neonates and children

(2011) Saskia N de Wildt   Expert Opinion on Drug Metabolism & Toxicology

Pediatric Cardiovascular Drug Dosing in Critically Ill Children and Extracorporeal Membrane Oxygenation

(2011) Kevin Watt et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The Pharmacogenetics of NAT2 Enzyme Maturation in Perinatally HIV Exposed Infants Receiving Isoniazid

(2011) Rui Zhu et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Postnatal trends in creatinemia and its covariates in extremely low birth weight (ELBW) neonates

(2011) Isabel George et al.   PEDIATRIC NEPHROLOGY

Innovative clinical trial design for pediatric therapeutics

(2011) Matthew M Laughon et al.   Expert Review of Clinical Pharmacology

Pharmacokinetics of Cefotaxime and Desacetylcefotaxime in Infants during Extracorporeal Membrane Oxygenation

(2010) M. J. Ahsman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Population Pharmacokinetics of Midazolam and Its Metabolites during Venoarterial Extracorporeal Membrane Oxygenation in Neonates

(2010) Maurice J. Ahsman et al.   CLINICAL PHARMACOKINETICS

The role of population PK–PD modelling in paediatric clinical research

(2010) Roosmarijn F. W. De Cock et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Determinants of drug absorption in different ECMO circuits

(2010) E. D. Wildschut et al.   INTENSIVE CARE MEDICINE

Understanding the Relative Roles of Pharmacogenetics and Ontogeny in Pediatric Drug Development and Regulatory Science

(2010) J. Steven Leeder et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Towards evidence-based pharmacotherapy in children

(2010) Elles Marleen Kemper et al.   PEDIATRIC ANESTHESIA

Plasma aminotransferase concentrations in preterm infants

(2009) S. Victor et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Facilitation of Drug Evaluation in Children by Population Methods and Modelling†

(2009) Michel Tod et al.   CLINICAL PHARMACOKINETICS

Potential Roles and Clinical Utility of Prebiotics in Newborns, Infants, and Children: Proceedings from a Global Prebiotic Summit Meeting, New York City, June 27-28, 2008

(2009) Philip M. Sherman et al.   JOURNAL OF PEDIATRICS

Serum Gentamicin Concentrations in Encephalopathic Infants are Not Affected by Therapeutic Hypothermia

(2009) X. Liu et al.   PEDIATRICS

Covariates of tramadol disposition in the first months of life

(2008) K. Allegaert et al.   BRITISH JOURNAL OF ANAESTHESIA

Effectiveness of a Barcode Medication Administration System in Reducing Preventable Adverse Drug Events in a Neonatal Intensive Care Unit: A Prospective Cohort Study

(2008) Frank H. Morriss et al.   JOURNAL OF PEDIATRICS