Profound changes in drug metabolism enzymes and possible effects on drug therapy in neonates and children

Oral Session III-B (OIII-B)Immunomodulation9:30 am – 10:30 am

(2010)   CLINICAL PHARMACOLOGY & THERAPEUTICS

Dosing in Children

(2010) N Holford   CLINICAL PHARMACOLOGY & THERAPEUTICS

OPRM1 and CYP2B6 Gene Variants as Risk Factors in Methadone-Related Deaths

(2010) H Bunten et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Comparison of Enzyme Kinetic Parameters Obtained In Vitro for Reactions Mediated by Human CYP2C Enzymes Including Major CYP2C9 Variants

(2010) D. Rokitta et al.   CURRENT DRUG METABOLISM

Impact of the CYP2C19*17 Allele on the Pharmacokinetics of Omeprazole and Pantoprazole in Children: Evidence for a Differential Effect

(2010) G. L. Kearns et al.   DRUG METABOLISM AND DISPOSITION

Single-dose, multiple-dose, and population pharmacokinetics of pantoprazole in neonates and preterm infants with a clinical diagnosis of gastroesophageal reflux disease (GERD)

(2010) Robert M. Ward et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Understanding the Relative Roles of Pharmacogenetics and Ontogeny in Pediatric Drug Development and Regulatory Science

(2010) J. Steven Leeder et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Developmental pharmacology of tramadol during infancy: ontogeny, pharmacogenetics and elimination clearance

(2010) Karel Allegaert et al.   PEDIATRIC ANESTHESIA

A maturation model for midazolam clearance

(2010) Brian J. Anderson et al.   PEDIATRIC ANESTHESIA

Evaluation of drug formularies for pediatric intensive care

(2010) Ilse Ceelie et al.   Pediatric Critical Care Medicine

Fatal Hydrocodone Overdose in a Child: Pharmacogenetics and Drug Interactions

(2010) P. Madadi et al.   PEDIATRICS

Are Cytochrome P450 CYP2C8 and CYP2C9 Polymorphisms Associated with Ibuprofen Response in Very Preterm Infants?

(2010) Xavier Durrmeyer et al.   PLoS One

Genetic Polymorphism and Toxicology—With Emphasis on Cytochrome P450

(2010) Inger Johansson et al.   TOXICOLOGICAL SCIENCES

Role of CYP2B6 in Stereoselective Human Methadone Metabolism

(2009) Rheem A. Totah et al.   ANESTHESIOLOGY

Prolonged neutropenia after irinotecan-based chemotherapy in a child with polymorphisms of UGT1A1 and SLCO1B1

(2009) S Sakaguchi et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Human hepatic CYP2B6 developmental expression: The impact of age and genotype

(2009) Edward L. Croom et al.   BIOCHEMICAL PHARMACOLOGY

Population pharmacokinetics of intravenous pantoprazole in paediatric intensive care patients

(2009) Géraldine Pettersen et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Morphine Glucuronidation in Preterm Neonates, Infants and Children Younger than 3 Years

(2009) Catherijne A.J. Knibbe et al.   CLINICAL PHARMACOKINETICS

Identification of Human UGT2B7 as the Major Isoform Involved in the O-Glucuronidation of Chloramphenicol

(2009) M. Chen et al.   DRUG METABOLISM AND DISPOSITION

In Vitro Hepatic Metabolism Explains Higher Clearance of Voriconazole in Children versus Adults: Role of CYP2C19 and Flavin-Containing Monooxygenase 3

(2009) S. B. Yanni et al.   DRUG METABOLISM AND DISPOSITION

Mechanistic Basis of Using Body Size and Maturation to Predict Clearance in Humans

(2009) Brian J. Anderson et al.   Drug Metabolism and Pharmacokinetics

Codeine, Ultrarapid-Metabolism Genotype, and Postoperative Death

(2009) Catherine Ciszkowski et al.   NEW ENGLAND JOURNAL OF MEDICINE

In Vivo Glucuronidation Activity of Drugs in Neonates: Extensive Interindividual Variability Despite Their Young Age

(2009) Karel Allegaert et al.   THERAPEUTIC DRUG MONITORING

Morphine pharmacokinetics and pharmacodynamics in preterm and term neonates: secondary results from the NEOPAIN trial

(2008) K.J.S. Anand et al.   BRITISH JOURNAL OF ANAESTHESIA

Pharmacokinetics of irinotecan and its metabolites in pediatric cancer patients: a report from the children’s oncology group

(2008) Patrick A. Thompson et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Reduced Activities of Cytochrome P450 1A2 and Xanthine Oxidase in Children With Growth Hormone Deficiency

(2008) MJ Kennedy et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Six-month, prospective, longitudinal, open-Label caffeine and dextromethorphan phenotyping study in children with growth hormone deficiency receiving recombinant human growth hormone replacement

(2008) Mary Jayne Kennedy et al.   CLINICAL THERAPEUTICS

Challenges for drug studies in children: CYP3A phenotyping as example

(2008) Saskia N. de Wildt et al.   DRUG DISCOVERY TODAY

Tailor-made drug treatment for children

(2008) Ibrahim Ince et al.   DRUG DISCOVERY TODAY

Developmental Changes in Human Liver CYP2D6 Expression

(2008) J. C. Stevens et al.   DRUG METABOLISM AND DISPOSITION

Population Pharmacokinetic Analysis of Ibuprofen Enantiomers in Preterm Newborn Infants

(2008) Nicolas Gregoire et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The ontogeny of drug metabolism enzymes and implications for adverse drug events

(2008) Ronald N. Hines   PHARMACOLOGY & THERAPEUTICS

Caffeine Citrate Treatment for Extremely Premature Infants With Apnea: Population Pharmacokinetics, Absolute Bioavailability, and Implications for Therapeutic Drug Monitoring

(2008) Bruce G Charles et al.   THERAPEUTIC DRUG MONITORING

Population pharmacokinetics and dose simulation of carvedilol in paediatric patients with congestive heart failure

(2007) Stefanie Albers et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Development of CYP2D6 and CYP3A4 in the First Year of Life

(2007) TN Johnson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Oral anticoagulation with warfarin is significantly influenced by steroids and CYP2C9 polymorphisms in children with cancer

(2007) Ellen Ruud et al.   PEDIATRIC BLOOD & CANCER