Basic Tetrapeptides as Potent Intracellular Inhibitors of Type A Botulinum Neurotoxin Protease Activity

Light Chain Separated from the Rest of the Type A Botulinum Neurotoxin Molecule Is the Most Catalytically Active Form

(2010) Nizamettin Gul et al.   PLoS One

Rapid product analysis and increased sensitivity for quantitative determinations of botulinum neurotoxin proteolytic activity

(2009) Benjamin Rowe et al.   ANALYTICAL BIOCHEMISTRY

Identification and Biochemical Characterization of Small-Molecule Inhibitors of Clostridium botulinum Neurotoxin Serotype A

(2009) V. Roxas-Duncan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacophore-guided lead optimization: The rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease

(2009) J.C. Burnett et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Extreme sensitivity of botulinum neurotoxin domains towards mild agitation

(2009) Stephen I. Toth et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Potent New Small-Molecule Inhibitor of Botulinum Neurotoxin Serotype A Endopeptidase Developed by Synthesis-Based Computer-Aided Molecular Design

(2009) Yuan-Ping Pang et al.   PLoS One

Tandem fluorescent proteins as enhanced FRET-based substrates for botulinum neurotoxin activity

(2009) Melissa Pires-Alves et al.   TOXICON

Investigations into small molecule non-peptidic inhibitors of the botulinum neurotoxins

(2009) Kateřina Čapková et al.   TOXICON

Lipid and cationic polymer based transduction of botulinum holotoxin, or toxin protease alone, extends the target cell range and improves the efficiency of intoxication

(2009) Chueh-Ling Kuo et al.   TOXICON

Catalytic Features of the Botulinum Neurotoxin A Light Chain Revealed by High Resolution Structure of an Inhibitory Peptide Complex†‡

(2008) Nicholas R. Silvaggi et al.   BIOCHEMISTRY

SNAP-25 Substrate Peptide (Residues 180–183) Binds to but Bypasses Cleavage by Catalytically ActiveClostridium botulinumNeurotoxin E

(2008) Rakhi Agarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure- and Substrate-based Inhibitor Design forClostridium botulinumNeurotoxin Serotype A

(2008) Desigan Kumaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate

(2008) Jorge E. Zuniga et al.   STRUCTURE

Substrate Binding Mode and Its Implication on Drug Design for Botulinum Neurotoxin A

(2008) Desigan Kumaran et al.   PLoS Pathogens

Methodological and cellular aspects that govern the internalization mechanisms of arginine-rich cell-penetrating peptides

(2007) Ikuhiko Nakase et al.   ADVANCED DRUG DELIVERY REVIEWS