Endothelial nanomedicine for the treatment of pulmonary disease

A Novel Vascular Homing Peptide Strategy to Selectively Enhance Pulmonary Drug Efficacy in Pulmonary Arterial Hypertension

(2014) Michie Toba et al.   AMERICAN JOURNAL OF PATHOLOGY

Keratinocyte Growth Factor Promotes Epithelial Survival and Resolution in a Human Model of Lung Injury

(2014) Murali Shyamsundar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Prevention of Ventilator-Induced Lung Edema by Inhalation of Nanoparticles Releasing Ruthenium Red

(2014) Samuel C. Jurek et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Nanocarriers for Vascular Delivery of Anti-Inflammatory Agents

(2014) Melissa D. Howard et al.   Annual Review of Pharmacology and Toxicology

Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation

(2014) Elizabeth D. Hood et al.   BIOMATERIALS

Endothelial targeting of liposomes encapsulating SOD/catalase mimetic EUK-134 alleviates acute pulmonary inflammation

(2014) Melissa D. Howard et al.   JOURNAL OF CONTROLLED RELEASE

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(2014) Patrick Crosswhite et al.   MOLECULAR MEDICINE

Fibrinolysis for Patients with Intermediate-Risk Pulmonary Embolism

(2014) Guy Meyer et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Case Series of Patients with Severe Pulmonary Hypertension Receiving an Implantable Pump for Intravenous Prostanoid Therapy

(2013) Ralf Ewert et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Advanced drug delivery systems for antithrombotic agents

(2013) C. F. Greineder et al.   BLOOD

Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension

(2013) Marius M. Hoeper et al.   CIRCULATION

Combination Therapy in Pulmonary Arterial Hypertension

(2013) Meredith E. Pugh et al.   CLINICS IN CHEST MEDICINE

VE-Cadherin and Endothelial Adherens Junctions: Active Guardians of Vascular Integrity

(2013) Monica Giannotta et al.   DEVELOPMENTAL CELL

Complement activation by PEGylated liposomes containing prednisolone

(2013) Jolanda M. van den Hoven et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Effect of Heart Rate Control With Esmolol on Hemodynamic and Clinical Outcomes in Patients With Septic Shock

(2013) Andrea Morelli et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Liposomal fasudil, a rho-kinase inhibitor, for prolonged pulmonary preferential vasodilation in pulmonary arterial hypertension

(2013) Vivek Gupta et al.   JOURNAL OF CONTROLLED RELEASE

The interaction between Toll-like receptor 4 signaling pathway and hypoxia-inducible factor 1α in lung ischemia–reperfusion injury

(2013) Zhiyi Zhou et al.   JOURNAL OF SURGICAL RESEARCH

The Potential Efficacy of R8-Modified Paclitaxel-Loaded Liposomes on Pulmonary Arterial Hypertension

(2013) Yujia Yin et al.   PHARMACEUTICAL RESEARCH

Creation of Lung-Targeted Dexamethasone Immunoliposome and Its Therapeutic Effect on Bleomycin-Induced Lung Injury in Rats

(2013) Xue-Yuan Chen et al.   PLoS One

Anti-Inflammatory Effect of Targeted Delivery of SOD to Endothelium: Mechanism, Synergism with NO Donors and Protective Effects In Vitro and In Vivo

(2013) Vladimir V. Shuvaev et al.   PLoS One

Vascular Immunotargeting to Endothelial Determinant ICAM-1 Enables Optimal Partnering of Recombinant scFv-Thrombomodulin Fusion with Endogenous Cofactor

(2013) Colin F. Greineder et al.   PLoS One

Primary Graft Dysfunction

(2013) Yoshikazu Suzuki et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Dysregulation of the angiopoietin–Tie-2 axis in sepsis and ARDS

(2013) Samir M Parikh   Virulence

Systemic and Biophase Bioavailability and Pharmacokinetics of Nanoparticulate Drug Delivery Systems

(2013) Sorin Emilian Leucuta   Current Drug Delivery

The effect of intravenous interferon-beta-1a (FP-1201) on lung CD73 expression and on acute respiratory distress syndrome mortality: an open-label study

(2013) Geoff Bellingan et al.   Lancet Respiratory Medicine

A porcine model of complement-mediated infusion reactions to drug carrier nanosystems and other medicines

(2012) János Szebeni et al.   ADVANCED DRUG DELIVERY REVIEWS

Therapy and outcomes in massive pulmonary embolism from the Emergency Medicine Pulmonary Embolism in the Real World Registry

(2012) Brian W. Lin et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Severe Pulmonary Arterial Hypertension Induced by SU5416 and Ovalbumin Immunization

(2012) Shiro Mizuno et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Design of polymeric nanoparticles for biomedical delivery applications

(2012) Mahmoud Elsabahy et al.   CHEMICAL SOCIETY REVIEWS

Histone Deacetylation Inhibition in Pulmonary Hypertension

(2012) Lan Zhao et al.   CIRCULATION

Models and mechanisms of acute lung injury caused by direct insults

(2012) Lucy Kathleen Reiss et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Pathobiology of pulmonary arterial hypertension and right ventricular failure

(2012) Norbert F. Voelkel et al.   EUROPEAN RESPIRATORY JOURNAL

Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome

(2012) Cory M Yamashita et al.   EXPERT OPINION ON EMERGING DRUGS

Programmable nanoparticle functionalization for in vivo targeting

(2012) Hua Pan et al.   FASEB JOURNAL

The acute respiratory distress syndrome

(2012) Michael A. Matthay et al.   JOURNAL OF CLINICAL INVESTIGATION

Antioxidant protection by PECAM-targeted delivery of a novel NADPH-oxidase inhibitor to the endothelium in vitro and in vivo

(2012) Elizabeth D. Hood et al.   JOURNAL OF CONTROLLED RELEASE

Macromolecular therapeutics in cancer treatment: The EPR effect and beyond

(2012) Hiroshi Maeda   JOURNAL OF CONTROLLED RELEASE

Gene Therapy by Targeted Adenovirus-mediated Knockdown of Pulmonary Endothelial Tph1 Attenuates Hypoxia-induced Pulmonary Hypertension

(2012) Ian Morecroft et al.   MOLECULAR THERAPY

A soluble guanylate cyclase stimulator, BAY 41-8543, preserves right ventricular function in experimental pulmonary embolism

(2012) John A. Watts et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Platelet-mediated vascular dysfunction during acute lung injury

(2012) James T. Dixon et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

PRINT: A Novel Platform Toward Shape and Size Specific Nanoparticle Theranostics

(2011) Jillian L. Perry et al.   ACCOUNTS OF CHEMICAL RESEARCH

Endothelial Targeting of Antibody-Decorated Polymeric Filomicelles

(2011) Vladimir V. Shuvaev et al.   ACS Nano

The effects of polymeric nanostructure shape on drug delivery

(2011) Shrinivas Venkataraman et al.   ADVANCED DRUG DELIVERY REVIEWS

Peptide-Directed Highly Selective Targeting of Pulmonary Arterial Hypertension

(2011) Takeo Urakami et al.   AMERICAN JOURNAL OF PATHOLOGY

Randomized, Placebo-controlled Clinical Trial of an Aerosolized β2-Agonist for Treatment of Acute Lung Injury

(2011)   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibition of MicroRNA-17 Improves Lung and Heart Function in Experimental Pulmonary Hypertension

(2011) Soni S. Pullamsetti et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhaled Nitric Oxide for Acute Respiratory Distress Syndrome and Acute Lung Injury in Adults and Children

(2011) Arash Afshari et al.   ANESTHESIA AND ANALGESIA

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

Liposome-encapsulated dexamethasone attenuates ventilator-induced lung inflammation

(2011) MA Hegeman et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeted nanocarriers for imaging and therapy of vascular inflammation

(2011) Ann-Marie Chacko et al.   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

Targeted gene delivery of BMPR2 attenuates pulmonary hypertension

(2011) A. M. Reynolds et al.   EUROPEAN RESPIRATORY JOURNAL

Gene therapy for pulmonary hypertension: prospects and challenges

(2011) Paul N Reynolds   EXPERT OPINION ON BIOLOGICAL THERAPY

Nanoparticle-Mediated Delivery of Pitavastatin Into Lungs Ameliorates the Development and Induces Regression of Monocrotaline-Induced Pulmonary Artery Hypertension

(2011) Ling Chen et al.   HYPERTENSION

Delivery of nanoparticle-complexed drugs across the vascular endothelial barrier via caveolae

(2011) Zhenjia Wang et al.   IUBMB LIFE

Catalase and Superoxide Dismutase Conjugated with Platelet-Endothelial Cell Adhesion Molecule Antibody Distinctly Alleviate Abnormal Endothelial Permeability Caused by Exogenous Reactive Oxygen Species and Vascular Endothelial Growth Factor

(2011) J. Han et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Effect of intravenous β-2 agonist treatment on clinical outcomes in acute respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial

(2011) Fang Gao Smith et al.   LANCET

Nanocarriers for vascular delivery of antioxidants

(2011) Elizabeth Hood et al.   Nanomedicine

Normothermic Ex Vivo Lung Perfusion in Clinical Lung Transplantation

(2011) Marcelo Cypel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients

(2011) F. I. Staquicini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non–Muscle Myosin Light Chain Kinase Isoform Is a Viable Molecular Target in Acute Inflammatory Lung Injury

(2010) Tamara Mirzapoiazova et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Vascular Cell Adhesion Molecule-1 Expression and Signaling During Disease: Regulation by Reactive Oxygen Species and Antioxidants

(2010) Joan M. Cook-Mills et al.   ANTIOXIDANTS & REDOX SIGNALING

Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets

(2010) Benedikt Treml et al.   CRITICAL CARE MEDICINE

PECAM-targeted delivery of SOD inhibits endothelial inflammatory response

(2010) Vladimir V. Shuvaev et al.   FASEB JOURNAL

Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension

(2010) Hiroshi Fujita et al.   HEART AND VESSELS

Comparison of lung accumulation of cationic liposomes in normal rats and LPS-treated rats

(2010) Susanne Herber-Jonat et al.   INFLAMMATION RESEARCH

Heterogeneous distribution of angiotensin I-converting enzyme (CD143) in the human and rat vascular systems: Vessel, organ and species specificity

(2010) Roman Metzger et al.   MICROVASCULAR RESEARCH

Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs

(2010) K. N. Sugahara et al.   SCIENCE

Leveraging Molecular Heterogeneity of the Vascular Endothelium for Targeted Drug Delivery and Imaging

(2010) Renata Pasqualini et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Anchoring Fusion Thrombomodulin to the Endothelial Lumen Protects against Injury-induced Lung Thrombosis and Inflammation

(2009) Bi-Sen Ding et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of Epidermal Growth Factor Inhibition in Experimental Pulmonary Hypertension

(2009) Bhola Kumar Dahal et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Complement-Mediated Ischemia-Reperfusion Injury

(2009) Gwendolyn M. P. Diepenhorst et al.   ANNALS OF SURGERY

Filamentous Polymer Nanocarriers of Tunable Stiffness that Encapsulate the Therapeutic Enzyme Catalase

(2009) Eric A. Simone et al.   BIOMACROMOLECULES

Pre-ischaemic conditioning of the pulmonary endothelium by immunotargeting of catalase via angiotensin-converting-enzyme antibodies☆☆☆

(2009) Kai Nowak et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Nanoparticle-Mediated Delivery of Nuclear Factor κB Decoy Into Lungs Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension

(2009) Satoshi Kimura et al.   HYPERTENSION

Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents

(2009) Mohamed Izikki et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted Detoxification of Selected Reactive Oxygen Species in the Vascular Endothelium

(2009) V. V. Shuvaev et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery

(2008) Monty Liong et al.   ACS Nano

Animal models of acute lung injury

(2008) Gustavo Matute-Bello et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Platelet-derived Growth Factor Expression and Function in Idiopathic Pulmonary Arterial Hypertension

(2008) Frédéric Perros et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Cancer Paradigm of Severe Pulmonary Arterial Hypertension

(2008) Pradeep R. Rai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophil Elastase Is Needed for Neutrophil Emigration into Lungs in Ventilator-Induced Lung Injury

(2008) A. Murat Kaynar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Redox Control of Endothelial Function and Dysfunction: Molecular Mechanisms and Therapeutic Opportunities

(2008) Shane R. Thomas et al.   ANTIOXIDANTS & REDOX SIGNALING

Cicletanine for the Treatment of Pulmonary Arterial Hypertension

(2008) Aaron B. Waxman et al.   ARCHIVES OF INTERNAL MEDICINE

Interleukin-6 Overexpression Induces Pulmonary Hypertension

(2008) M. Kathryn Steiner et al.   CIRCULATION RESEARCH

Effects of pentoxifylline on TNF-alpha and lung histopathology in HCL-induced lung injury

(2008) Itamar Souza de Oliveira-Júnior et al.   Clinics

Effectiveness of liposomal-N-acetylcysteine against LPS-induced lung injuries in rodents

(2008) Panagiotis Mitsopoulos et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Differential intra-endothelial delivery of polymer nanocarriers targeted to distinct PECAM-1 epitopes

(2008) C GARNACHO et al.   JOURNAL OF CONTROLLED RELEASE

Loading PEG-Catalase into Filamentous and Spherical Polymer Nanocarriers

(2008) Eric A. Simone et al.   PHARMACEUTICAL RESEARCH

Endothelial pathomechanisms in acute lung injury

(2008) Nikolaos A. Maniatis et al.   VASCULAR PHARMACOLOGY

Endothelial targeting of semi-permeable polymer nanocarriers for enzyme therapies

(2007) Thomas D. Dziubla et al.   BIOMATERIALS