Article
Biochemical Research Methods
Weibo Zhang, Jie Lyu, Juxiang Xu, Piao Zhang, Shuxia Zhang, Yeru Chen, Yongjie Wang, Gang Chen
Summary: This study revealed that chronic inflammation pain induced by CFA injection resulted in abnormal expression of 27 metabolites and enrichment of seven metabolic pathways, potentially implicating neurotransmitter release and pain conductivity.
BIOMEDICAL CHROMATOGRAPHY
(2021)
Review
Geriatrics & Gerontology
Xin-Yi Dai, Lin Liu, Fan-He Song, Shao-Jie Gao, Jia-Yi Wu, Dan-Yang Li, Long-Qing Zhang, Dai-Qiang Liu, Ya-Qun Zhou, Wei Mei
Summary: Chronic pain is a significant health concern due to its common occurrence, long-lasting nature, and associated mental stress. The JAK2/STAT3 signaling pathway has been found to play a crucial role in different stages of chronic pain, and inhibitors targeting this pathway show therapeutic potential. Activation of JAK2/STAT3 triggers chronic pain by interacting with microglia and astrocytes, releasing proinflammatory cytokines, inhibiting anti-inflammatory cytokines, and affecting synaptic plasticity. Retrospective analysis of pharmacological inhibitors for JAK2/STAT3 reveals their promising effect in treating different types of chronic pain.
Review
Chemistry, Medicinal
Hasriadi, Peththa Wadu Dasuni Wasana, Opa Vajragupta, Pornchai Rojsitthisak, Pasarapa Towiwat
Summary: Chronic pain is heavily influenced by neuroinflammation, specifically the activation of microglia and astrocytes leading to neuronal excitability. Curcumin, found in the Curcuma genus, shows promise in improving chronic pain by reducing inflammatory mediators released from spinal glia. It highlights the potential for curcumin to modulate microglia and astrocytes to suppress spinal neuroinflammation and provide effective treatment for chronic pain.
Article
Pharmacology & Pharmacy
M. Carmen Ruiz-Cantero, Rafael Gonzalez-Cano, Miguel A. Tejada, Miriam Santos-Caballero, Gloria Perazzoli, Francisco R. Nieto, Enrique J. Cobos
Summary: This article discusses the modulatory effects of sigma-1 receptors on communication between the immune and nervous systems during inflammation, as well as their influence on peripheral and central neuroinflammation. Experimental models show that sigma-1 receptor inhibition can prevent neuroinflammation and enhance immune-driven opioid analgesia, potentially making sigma-1 antagonists a new class of analgesics for various painful disorders.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yu-ting Wang, Kai Lu, Dan-dan Yao, Shu-xia Zhang, Gang Chen
Summary: In this study, Forsythoside B (FB) from Forsythia suspensa was found to be effective in relieving chronic inflammatory pain and exhibited anti-anxiety effects. The mechanisms involved the reduction of proinflammatory cytokines and modulation of microglia and astrocytes activation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Laszlo Ducza, Peter Szucs, Krisztina Hegedus, Erzsebet Bakk, Andrea Gajtko, Ildiko Weber, Krisztina Hollo
Summary: The study demonstrates that IL-1 beta and IL-1R1 are overexpressed in spinal neurons and astrocytes in a persistent pain model, with the formation of inflammasomes affecting neuronal excitability to maintain pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Yuanyuan Wu, Yuerong Chen, Yunyun Xu, Wenqin Ni, Chalian Lin, Xiaomei Shao, Zui Shen, Xiaofen He, Chao Wang, Jianqiao Fang
Summary: Pain sufferers often dislike the environment associated with pain, known as pain aversion. The amygdala, a limbic structure in the brain, plays a critical role in emotion and pain. However, research on aversion caused by inflammatory pain is limited, and the underlying mechanisms are not well understood. This study used proteomics analysis to identify potential proteins involved in pain aversion in rats. Glutamate transporter-1 (GLT-1) was found to have correlation with pain aversion and may modulate the excitability of glutamatergic neurons. This study highlights the extensive biological changes in the amygdala induced by inflammatory pain.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nobuhiko Nakajima, Yuichiro Ohnishi, Masamichi Yamamoto, Daiki Setoyama, Hirohiko Imai, Tomofumi Takenaka, Mari Matsumoto, Koichi Hosomi, Yoichi Saitoh, Hidemasa Furue, Haruhiko Kishima
Summary: Intractable neuropathic pain following spinal cord injury (NP-SCI) reduces a patient's quality of life. Excessive buildup of intracellular ATP at the lesion site leads to the release of ATP with mechanical stimulation, causing NP-SCI. Neuroinflammation plays an important role in this process.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Nutrition & Dietetics
Reem S. S. Alazragi, Hanadi M. M. Baeissa
Summary: This study aimed to examine the anti-arthritic properties of grapefruit juice and found that it can reduce inflammation levels, slow down cartilage degradation, and improve joint function.
Article
Cell Biology
Diessica Padilha Dalenogare, Daniel Souza Monteiro de Araujo, Lorenzo Landini, Mustafa Titiz, Gaetano De Siena, Francesco De Logu, Pierangelo Geppetti, Romina Nassini, Gabriela Trevisan
Summary: This study evaluated the role of transient receptor potential ankyrin 1 (TRPA1) in neuroinflammation underlying pain-like symptoms in multiple sclerosis (MS). The results indicate that TRPA1 primarily promotes spinal neuroinflammation and further strengthens the inhibition of this channel to treat neuropathic pain in MS.
Article
Immunology
Chunling Huang, Lulu Sun, Chenyang Xiao, Wenjun You, Li Sun, Siye Wang, Zhijun Zhang, Su Liu
Summary: The expression level of circular RNA (circRNA) is upregulated in traumatic brain injury (TBI), which may contribute to neurodegenerative diseases. The circRNA METTL9 is identified as an important molecule that is upregulated after TBI and is involved in the pathological processes of TBI by regulating neuronal apoptosis and loss of function.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Quan Ma, Xi Chen, Jinli Sun, Li Wang, Weichao Jiang, Xi Zhang, Sifang Chen
Summary: The study found that complete Freund's adjuvant can induce mirror-image pain (MIP) and identified potential molecular mechanisms through quantitative proteomics in the spinal cord. Additionally, neuronal activity of spinal cord neurons is upregulated during MIP after CFA treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Immunology
George Sideris-Lampretsas, Marzia Malcangio
Summary: This review summarizes the existing preclinical evidence on how the CNS compartment and sex impact microglia functions in health, emphasizing recent advances in transcriptomics analyses for characterizing disease-associated microglial states. The specific scenario of peripheral nerve or tissue injury inducing expression of a specific subset of genes in microglia in the dorsal horn of the spinal cord is discussed, along with the possibility of a unique microglia transcriptional profile associated with chronic pain conditions. The evidence also suggests microglial activation in pain-related areas of the brain can be observed in models of neuropathic pain, highlighting the potential for future studies to further explore neuroimmune interactions in chronic pain using novel approaches like scRNA-seq and CYTOF.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Wen Yin, Li Liu, Yuxi Zhou, Yunchun Zhang, Dexu Kong, Saihong Xu, Dan Tang, Dan Huang, Daxiang Wen, Yingfu Jiao, Yinghui Fan, Po Gao, Weifeng Yu
Summary: The study showed that CFA treatment suppressed behaviors and calcium responses associated with TRPV1-mediated histamine-dependent itch and TRPA1-mediated histamine-independent itch. Furthermore, CFA treatment increased nociceptive DRG neurons but decreased most known pruriceptors, which may explain itch suppression. This study suggested a unified adaptive change of increased pain and decreased itch under CFA-induced inflammatory conditions.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Silvia Castany, Anna Bago-Mas, Jose Miguel Vela, Enrique Verdu, Karolina Bretova, Viktorie Svobodova, Petr Dubovy, Pere Boadas-Vaello
Summary: This study aimed to determine whether neuroinflammatory factor over-expression in the spinal cord and supraspinal structures may be associated with reflexive and nonreflexive pain response development from acute spinal cord injury (SCI) phase to 12 weeks post-injury in female mice. The results show that transient reflexive responses were observed during the SCI acute phase associated with transient cytokine overexpression in the spinal cord. In contrast, increased nonreflexive pain responses were observed in the chronic phase associated with cytokine overexpression in supraspinal structures, especially in mPFC. In addition, results revealed the contribution of neuron-glia crosstalk in the development of nonreflexive pain responses in the chronic spinal cord injury phase, as indicated by increased glial activation and CX3CL1/CX3CR1 upregulation in the neurons in the mPFC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Peng-Bo Jing, De-Li Cao, Si-Si Li, Meixuan Zhu, Xue-Qiang Bai, Xiao-Bo Wu, Yong-Jing Gao
NEUROSCIENCE BULLETIN
(2018)
Article
Neurosciences
Rou-Gang Xie, Yong-Jing Gao, Chul-Kyu Park, Ning Lu, Ceng Luo, Wen-Ting Wang, Sheng-Xi Wu, Ru-Rong Ji
NEUROSCIENCE BULLETIN
(2018)
Article
Neurosciences
Xiao-Bo Wu, Li-Na He, Bao-Chun Jiang, Xue Wang, Ying Lu, Yong-Jing Gao
NEUROSCIENCE BULLETIN
(2019)
Article
Immunology
Xiaojuan Liu, Raquel Tonello, Yuejuan Ling, Yong-Jing Gao, Temugin Berta
JOURNAL OF NEUROINFLAMMATION
(2019)
Review
Pharmacology & Pharmacy
Bao-Chun Jiang, Tong Liu, Yong-Jing Gao
PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Neurosciences
Hui Zhang, Sui-Bin Ma, Yong-Jing Gao, Jun-Ling Xing, Hang Xian, Zhen-Zhen Li, Shu-Ning Shen, Sheng-Xi Wu, Ceng Luo, Rou-Gang Xie
NEUROSCIENCE BULLETIN
(2020)
Article
Anesthesiology
Bao-Chun Jiang, Jing Zhang, Bin Wu, Ming Jiang, Hanzhong Cao, Hao Wu, Yong-Jing Gao
Summary: This study identified the involvement of Gpr151 in trigeminal neuropathic pain, showing its role in activating ERK-dependent neuroinflammation through G alpha i protein. Mutation of Gpr151 reduced the expression of neuroinflammation-related genes and alleviated mechanical allodynia.
Article
Neurosciences
Lin-Xia Zhao, Ming Jiang, Xue-Qiang Bai, De-Li Cao, Xiao-Bo Wu, Jing Zhang, Jian-Shuang Guo, Tong-Tong Chen, Juan Wang, Hao Wu, Yong-Jing Gao, Zhi-Jun Zhang
Summary: TLR8 expression is increased in trigeminal neuropathic pain, and targeting TLR8 signaling may be effective in reducing pain and neuroinflammation.
NEUROSCIENCE BULLETIN
(2021)
Article
Neurosciences
Yan-Fang Kong, Wei-Lin Sha, Xiao-Bo Wu, Lin-Xia Zhao, Ling-Jie Ma, Yong-Jing Gao
Summary: Chemokines and their receptors play a role in chronic pain pathogenesis, with CXCR3 and CXCL10 specifically influencing neuronal excitability in the dorsal root ganglion. Activation of CXCR3 by CXCL10 leads to p38 and ERK activation in DRG neurons, enhancing neuronal excitability and contributing to neuropathic pain maintenance.
NEUROSCIENCE BULLETIN
(2021)
Article
Clinical Neurology
Yue-Juan Ling, Ting-Yu Ding, Fu-Lu Dong, Yong-Jing Gao, Bao-Chun Jiang
JOURNAL OF PAIN RESEARCH
(2020)
Article
Cell Biology
Ying Lu, De-Li Cao, Ling-Jie Ma, Yong-Jing Gao
Summary: The study reveals that TRAF6 contributes to pain hypersensitivity by regulating microglial activation in the spinal dorsal horn. Direct or indirect inhibition of TRAF6, such as with siRNA or DHA, may have therapeutic effects on chronic inflammatory pain.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Xiao-Bo Wu, Qian Zhu, Yong-Jing Gao
Summary: The study showed that neuropathic pain affects the intensity of excitatory and inhibitory synaptic inputs to MSNs in the NAc shell, which in turn influences related behavioral outputs.
NEUROSCIENCE BULLETIN
(2021)
Letter
Neurosciences
Zi-Han Wu, Han-Yu Shao, Yuan-Yuan Fu, Xiao-Bo Wu, De-Li Cao, Sheng-Xiang Yan, Wei-Lin Sha, Yong-Jing Gao, Zhi-Jun Zhang
NEUROSCIENCE BULLETIN
(2021)
Article
Neurosciences
Peng-Bo Jing, Xiao-Hong Chen, Huan-Jun Lu, Yong-Jing Gao, Xiao-Bo Wu
Summary: NMDAR dysfunction in the NAc is involved in neurological and psychiatric disorders. This study demonstrates that the functional change of NR2C/2D subunits-containing NMDARs in the NAc may contribute to the sensory and affective components in neuropathic pain.
Article
Neurosciences
Yu-Feng Wang, Yong-Jing Gao