Microglial heterogeneity in chronic pain

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

Microglia Heterogeneity in the Single-Cell Era

(2020) Takahiro Masuda et al.   Cell Reports

Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map

(2020) Omer Ali Bayraktar et al.   NATURE NEUROSCIENCE

Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia

(2020) Peter L. Wang et al.   Nature Communications

Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System

(2020) Patrick Süß et al.   Cell Reports

Negative feedback control of neuronal activity by microglia

(2020) Ana Badimon et al.   NATURE

Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans

(2020) Nicola Thrupp et al.   Cell Reports

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Brain Microglial Activation in Chronic Pain-Associated Affective Disorder

(2019) Ellane Eda Barcelon et al.   Frontiers in Neuroscience

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

(2019) Marta Joana Costa Jordão et al.   SCIENCE

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia

(2019) Louis-Philippe Bernier et al.   Cell Reports

Disease activity in rheumatoid arthritis is inversely related to cerebral TSPO binding assessed by [11C]PBR28 positron emission tomography

(2019) A. Forsberg et al.   JOURNAL OF NEUROIMMUNOLOGY

Peripheral Nerve Injury Triggers Neuroinflammation in the Medial Prefrontal Cortex and Ventral Hippocampus in a Subgroup of Rats with Coincident Affective Behavioural Changes

(2019) Nathan T. Fiore et al.   NEUROSCIENCE

Microglial regional heterogeneity and its role in the brain

(2019) Yun-Long Tan et al.   MOLECULAR PSYCHIATRY

Differences of Microglia in the Brain and the Spinal Cord

(2019) Fang-Ling Xuan et al.   Frontiers in Cellular Neuroscience

Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program

(2019) Laufey Geirsdottir et al.   CELL

Transcriptional profiling of microglia; current state of the art and future perspectives

(2019) Emma Gerrits et al.   GLIA

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Epigenetic regulation of brain region-specific microglia clearance activity

(2018) Pinar Ayata et al.   NATURE NEUROSCIENCE

Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats

(2018) Josiane C.S. Mapplebeck et al.   PAIN

Brain Region-dependent Heterogeneity and Dose-dependent Difference in Transient Microglia Population Increase during Lipopolysaccharide-induced Inflammation

(2018) Eriko Furube et al.   Scientific Reports

Sex-Specific Features of Microglia from Adult Mice

(2018) Alessandro Villa et al.   Cell Reports

Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation

(2018) Daniel S. Albrecht et al.   BRAIN BEHAVIOR AND IMMUNITY

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures

(2018) Carole Sousa et al.   EMBO REPORTS

Exploring the transcriptome of resident spinal microglia after collagen antibody-induced arthritis

(2018) Teresa Fernandez-Zafra et al.   PAIN

Transcriptional and Translational Differences of Microglia from Male and Female Brains

(2018) Dilansu Guneykaya et al.   Cell Reports

Sexual differentiation of microglia

(2018) Alessandro Villa et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

(2018) Samira Parhizkar et al.   NATURE NEUROSCIENCE

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

(2018) Qingyun Li et al.   NEURON

Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity

(2017) Richa Hanamsagar et al.   GLIA

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

(2017) Thais F Galatro et al.   NATURE NEUROSCIENCE

Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia

(2017) Lindsay M. De Biase et al.   NEURON

Peripheral nerve injury induces a transitory microglial reaction in the rat infralimbic cortex

(2017) Paul Chu Sin Chung et al.   NEUROSCIENCE LETTERS

Spared Nerve Injury Increases the Expression of Microglia M1 Markers in the Prefrontal Cortex of Rats and Provokes Depression-Like Behaviors

(2017) Ning Xu et al.   Frontiers in Neuroscience

Sex differences in peripheral not central immune responses to pain-inducing injury

(2017) Douglas M. Lopes et al.   Scientific Reports

Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease

(2016) Willem Kamphuis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Spinal versus brain microglial and macrophage activation traits determine the differential neuroinflammatory responses and analgesic effect of minocycline in chronic neuropathic pain

(2016) Zhilin Li et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuron-immune mechanisms contribute to pain in early stages of arthritis

(2016) Francisco R. Nieto et al.   Journal of Neuroinflammation

Phenotypic clustering: a novel method for microglial morphology analysis

(2016) Franck Verdonk et al.   Journal of Neuroinflammation

TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury

(2016) Yong Liu et al.   JOURNAL OF NEUROSCIENCE

Topography of microglial activation in sensory- and affect-related brain regions in chronic pain

(2016) Anna M.W. Taylor et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Interleukin-1β overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents

(2016) Wen-Shan Gui et al.   Molecular Pain

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

High-resolution transcriptome analysis reveals neuropathic pain gene-expression signatures in spinal microglia after nerve injury

(2016) Heejin Jeong et al.   PAIN

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

(2016) Takahiro Masuda et al.   Nature Communications

Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury

(2016) Nan Gu et al.   Cell Reports

Persistent Alterations in Microglial Enhancers in a Model of Chronic Pain

(2016) Franziska Denk et al.   Cell Reports

The methodology of TSPO imaging with positron emission tomography

(2015) Federico E. Turkheimer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Evidence for brain glial activation in chronic pain patients

(2015) Marco L. Loggia et al.   BRAIN

Selective Activation of Microglia Facilitates Synaptic Strength

(2015) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

(2015) Zhonghui Guan et al.   NATURE NEUROSCIENCE

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Cognitive and emotional control of pain and its disruption in chronic pain

(2013) M. Catherine Bushnell et al.   NATURE REVIEWS NEUROSCIENCE

Glia and pain: Is chronic pain a gliopathy?

(2013) Ru-Rong Ji et al.   PAIN

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

(2012) Takahiro Masuda et al.   Cell Reports

Microglial signalling mechanisms: Cathepsin S and Fractalkine

(2011) Anna K. Clark et al.   EXPERIMENTAL NEUROLOGY

Spinal Cord Toll-Like Receptor 4 Mediates Inflammatory and Neuropathic Hypersensitivity in Male But Not Female Mice

(2011) R. E. Sorge et al.   JOURNAL OF NEUROSCIENCE

Blockade of TNF-α rapidly inhibits pain responses in the central nervous system

(2011) Andreas Hess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune response by microglia in the spinal cord

(2010) Julie K. Olson   Annals of the New York Academy of Sciences

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS

(2008) Alexander H. de Haas et al.   GLIA

P2Y12 Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury

(2008) H. Tozaki-Saitoh et al.   JOURNAL OF NEUROSCIENCE

P2Y12 Receptor Upregulation in Activated Microglia Is a Gateway of p38 Signaling and Neuropathic Pain

(2008) K. Kobayashi et al.   JOURNAL OF NEUROSCIENCE

Up-Regulation of P2X4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

(2008) L. Ulmann et al.   JOURNAL OF NEUROSCIENCE