Involvement of the endocannabinoid system in osteoarthritis pain

Safety and efficacy of duloxetine treatment in older and younger patients with osteoarthritis knee pain: a post hoc, subgroup analysis of two randomized, placebo-controlled trials

(2013) Joseph L Micca et al.   BMC MUSCULOSKELETAL DISORDERS

Immunopathogenesis of osteoarthritis

(2013) Abdul Haseeb et al.   CLINICAL IMMUNOLOGY

The Efficacy of Diacerein in Hand Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Study

(2013) Kichul Shin et al.   CLINICAL THERAPEUTICS

Useful animal models for the research of osteoarthritis

(2013) Kalliopi Lampropoulou-Adamidou et al.   European Journal of Orthopaedic Surgery and Traumatology

Disease-modifying osteoarthritis drugs:in vitroandin vivodata on the development of DMOADs under investigation

(2013) Peter SE Davies et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis

(2013) Timothy McAlindon et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee

(2012) Marie-Pierre Hellio le Graverand et al.   ANNALS OF THE RHEUMATIC DISEASES

The Endocannabinoid System and the Brain

(2012) Raphael Mechoulam et al.   Annual Review of Psychology

Clinical implications for cannabinoid use in the rheumatic diseases: Potential for help or harm?

(2012) Mary-Ann Fitzcharles et al.   ARTHRITIS AND RHEUMATISM

Cortisol-mediated adhesion of synovial fibroblasts is dependent on the degradation of anandamide and activation of the endocannabinoid system

(2012) Torsten Lowin et al.   ARTHRITIS AND RHEUMATISM

The Endocannabinoid System and Pain

(2012) Josee Guindon et al.   CNS & Neurological Disorders-Drug Targets

Cannabinoid Receptors and Endocannabinoids: Role in Neuroinflammatory and Neurodegenerative Disorders

(2012) Tiziana Bisogno et al.   CNS & Neurological Disorders-Drug Targets

Operant self-administration of a sigma ligand improves nociceptive and emotional manifestations of neuropathic pain

(2012) A.S. Bura et al.   EUROPEAN JOURNAL OF PAIN

Platelet-rich plasma loaded hydrogel scaffold enhances chondrogenic differentiation and maturation with up-regulation of CB1 and CB2

(2012) Hye-Rim Lee et al.   JOURNAL OF CONTROLLED RELEASE

An Open-Label Extension Study to Investigate the Long-Term Safety and Tolerability of THC/CBD Oromucosal Spray and Oromucosal THC Spray in Patients With Terminal Cancer-Related Pain Refractory to Strong Opioid Analgesics

(2012) Jeremy R. Johnson et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain

(2012) Bernard P. Roques et al.   NATURE REVIEWS DRUG DISCOVERY

What constitutes an “animal model of osteoarthritis” – the need for consensus?

(2012) C.B. Little et al.   OSTEOARTHRITIS AND CARTILAGE

Inhibitors of endocannabinoid breakdown for pain: Not so FA(AH)cile, after all

(2012) Vincenzo Di Marzo   PAIN

An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee

(2012) John P. Huggins et al.   PAIN

Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate

(2012) Carmen La Porta et al.   PAIN

Nanoparticles for Improved Local Retention after Intra-Articular Injection into the Knee Joint

(2012) Michael Morgen et al.   PHARMACEUTICAL RESEARCH

Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities

(2012) R. G. Pertwee   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mapping pathogenesis of arthritis through small animal models

(2012) T. L. Vincent et al.   RHEUMATOLOGY

Efficacy of an immunotoxin to folate receptor beta in the intra-articular treatment of antigen-induced arthritis

(2012) Taku Nagai et al.   ARTHRITIS RESEARCH & THERAPY

New findings in osteoarthritis pathogenesis: therapeutic implications

(2012) Lia Pulsatelli et al.   Therapeutic Advances in Chronic Disease

Current nutraceuticals in the management of osteoarthritis: a review

(2012) Nahid Akhtar et al.   Therapeutic Advances in Musculoskeletal Disease

Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis

(2011) Peter L. E. M. van Lent et al.   ARTHRITIS AND RHEUMATISM

Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain

(2011) Sumihisa Orita et al.   BMC MUSCULOSKELETAL DISORDERS

Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials

(2011) Mary E. Lynch et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Assessment of the pharmacology and tolerability of PF-04457845, an irreversible inhibitor of fatty acid amide hydrolase-1, in healthy subjects

(2011) Gai Ling Li et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro

(2011) LS Whyte et al.   BRITISH JOURNAL OF PHARMACOLOGY

Rates of inappropriate drug use in the chronic pain population: an update

(2011) K. Bronstein et al.   JOURNAL OF PAIN

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

(2011) K. Ahn et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pain Mechanisms in Osteoarthritis: Understanding the Role of Central Pain and Current Approaches to Its Treatment

(2011) P. J. MEASE et al.   JOURNAL OF RHEUMATOLOGY

Neurochemical basis of cannabis addiction

(2011) R. Maldonado et al.   NEUROSCIENCE

The association between meniscal and cruciate ligament damage and knee pain in community residents

(2011) H.A. Kim et al.   OSTEOARTHRITIS AND CARTILAGE

Self-medication of a cannabinoid CB2 agonist in an animal model of neuropathic pain

(2011) Tannia Gutierrez et al.   PAIN

What makes osteoarthritis painful? The evidence for local and central pain processing

(2011) N. Sofat et al.   RHEUMATOLOGY

Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain

(2010) Devi Rani Sagar et al.   ARTHRITIS AND RHEUMATISM

Targeting subchondral bone for treating osteoarthritis: what is the evidence?

(2010) Steeve Kwan Tat et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis

(2010) David J Hunter et al.   BMC MUSCULOSKELETAL DISORDERS

A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss

(2010) Alysia N. Lozano-Ondoua et al.   LIFE SCIENCES

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism

(2010) Jason R Clapper et al.   NATURE NEUROSCIENCE

Pharmacologic therapy for osteoarthritis—the era of disease modification

(2010) David J. Hunter   Nature Reviews Rheumatology

The bone–cartilage unit in osteoarthritis

(2010) Rik J. Lories et al.   Nature Reviews Rheumatology

Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain

(2010) N. Schuelert et al.   OSTEOARTHRITIS AND CARTILAGE

Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor

(2010) P.S. Chockalingam et al.   OSTEOARTHRITIS AND CARTILAGE

Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis

(2010) Niklas Schuelert et al.   PAIN

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

A Double-blind, Randomized, Placebo-controlled Study of the Efficacy and Safety of Duloxetine for the Treatment of Chronic Pain Due to Osteoarthritis of the Knee

(2010) Amy S. Chappell et al.   Pain Practice

Reduction of Bone Cancer Pain by Activation of Spinal Cannabinoid Receptor 1 and Its Expression in the Superficial Dorsal Horn of the Spinal Cord in a Murine Model of Bone Cancer Pain

(2009) Shingo Furuse et al.   ANESTHESIOLOGY

Emerging strategies for exploiting cannabinoid receptor agonists as medicines

(2009) Roger G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacological modulation of movement-evoked pain in a rat model of osteoarthritis

(2009) Prasant Chandran et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression

(2009) Sadiye Amcaoglu Rieder et al.   IMMUNOBIOLOGY

Descending Serotonergic Facilitation and the Antinociceptive Effects of Pregabalin in a Rat Model of Osteoarthritic Pain

(2009) Wahida Rahman et al.   Molecular Pain

Behavioural and Electrophysiological Characterisation of Experimentally Induced Osteoarthritis and Neuropathy in C57Bl/6 Mice

(2009) Victoria L Harvey et al.   Molecular Pain

The effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study

(2009) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Systematic Review and Meta-analysis of Cannabis Treatment for Chronic Pain

(2009) Eva Martín-Sánchez et al.   PAIN MEDICINE

Endocannabinoid-Mediated Control of Synaptic Transmission

(2009) Masanobu Kano et al.   PHYSIOLOGICAL REVIEWS

Joint pain

(2009) Hans-Georg Schaible et al.   EXPERIMENTAL BRAIN RESEARCH

Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI

(2008) J-P Raynauld et al.   ANNALS OF THE RHEUMATIC DISEASES

Adverse effects of medical cannabinoids: a systematic review

(2008) T. Wang et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Quinolone-induced arthropathy: an update focusing on new mechanistic and clinical data

(2008) Judith Sendzik et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

A Decrease in Anandamide Signaling Contributes to the Maintenance of Cutaneous Mechanical Hyperalgesia in a Model of Bone Cancer Pain

(2008) I. A. Khasabova et al.   JOURNAL OF NEUROSCIENCE

Crucial Role of CB2 Cannabinoid Receptor in the Regulation of Central Immune Responses during Neuropathic Pain

(2008) I. Racz et al.   JOURNAL OF NEUROSCIENCE

A Preliminary fMRI Study of Analgesic Treatment in Chronic Back Pain and Knee Osteoarthritis

(2008) Marwan N Baliki et al.   Molecular Pain

Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment – a systematic approach

(2008) Y.H. Sniekers et al.   OSTEOARTHRITIS AND CARTILAGE

OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

(2008) W. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Preclinical animal models in single site cartilage defect testing: a systematic review

(2008) B.J. Ahern et al.   OSTEOARTHRITIS AND CARTILAGE

Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons

(2008) Uma Anand et al.   PAIN

Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis

(2008) Denise Richardson et al.   ARTHRITIS RESEARCH & THERAPY

In vivoeffects of CB2receptor-selective cannabinoids on the vasculature of normal and arthritic rat knee joints

(2007) J J McDougall et al.   BRITISH JOURNAL OF PHARMACOLOGY

In vitroandin vivocharacterization of A-796260: a selective cannabinoid CB2receptor agonist exhibiting analgesic activity in rodent pain models

(2007) B B Yao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate

(2007) K Rea et al.   BRITISH JOURNAL OF PHARMACOLOGY