Epigenetic alterations and microRNAs

miR-21 mediates hematopoietic suppression in MDS by activating TGF-  signaling

(2013) T. D. Bhagat et al.   BLOOD

Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia

(2012) S. Tanaka et al.   BLOOD

Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression

(2012) G. Zardo et al.   BLOOD

ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression

(2012) Omar Abdel-Wahab et al.   CANCER CELL

Aberrant promoter methylation of Dab2 gene in myelodysplastic syndrome

(2012) Yujuan Yang et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Transcriptional regulation of miR-10a/b by TWIST-1 in myelodysplastic syndromes

(2012) X. Li et al.   HAEMATOLOGICA

Impaired expression of DICER, DROSHA, SBDS and some microRNAs in mesenchymal stromal cells from myelodysplastic syndrome patients

(2012) C. Santamaria et al.   HAEMATOLOGICA

Aberration ofp73promoter methylation inde novomyelodysplastic syndrome

(2012) Youshan Zhao et al.   Hematology

Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases

(2012) Véronique Gelsi-Boyer et al.   Journal of Hematology & Oncology

Hypermethylation of Wnt antagonist gene promoters and activation of Wnt pathway in myelodysplastic marrow cells

(2012) Erico Masala et al.   LEUKEMIA RESEARCH

TET2, ASXL1 and EZH2 mutations in Chinese with myelodysplastic syndromes

(2012) Jieyu Wang et al.   LEUKEMIA RESEARCH

Expression analysis of mir-17-5p, mir-20a and let-7a microRNAs and their target proteins in CD34+ bone marrow cells of patients with myelodysplastic syndromes

(2012) Diamantina Vasilatou et al.   LEUKEMIA RESEARCH

Methylation of the CpG Island Near SOX7 Gene Promoter Is Correlated with the Poor Prognosis of Patients with Myelodysplastic Syndrome

(2012) Rong Fan et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease

(2012) A. Herrera-Merchan et al.   Nature Communications

Phase II study of the histone deacetylase inhibitor belinostat (PXD101) for the treatment of myelodysplastic syndrome (MDS)

(2011) Amanda Cashen et al.   ANNALS OF HEMATOLOGY

Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms

(2011) J. Score et al.   BLOOD

Identification of a risk dependent microRNA expression signature in myelodysplastic syndromes

(2011) Lubomir Sokol et al.   BRITISH JOURNAL OF HAEMATOLOGY

Overexpression of BMI1 confers clonal cells resistance to apoptosis and contributes to adverse prognosis in myelodysplastic syndrome

(2011) Feng Xu et al.   CANCER LETTERS

Epigenetic dysregulation of GATA1 is involved in myelodysplastic syndromes dyserythropoiesis

(2011) Olaf Hopfer et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Diagnostic microRNAs in myelodysplastic syndrome

(2011) Begum Erdogan et al.   EXPERIMENTAL HEMATOLOGY

Rare occurrence of DNMT3A mutations in myelodysplastic syndromes

(2011) F. Thol et al.   HAEMATOLOGICA

Aberrant Epigenetic and Genetic Marks Are Seen in Myelodysplastic Leukocytes and RevealDock4as a Candidate Pathogenic Gene on Chromosome 7q

(2011) Li Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myelodysplastic Syndrome and Histone Deacetylase Inhibitors: “To Be or Not to Be Acetylated”?

(2011) Sebastian Stintzing et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Prognostic Significance of ASXL1 Mutations in Patients With Myelodysplastic Syndromes

(2011) Felicitas Thol et al.   JOURNAL OF CLINICAL ONCOLOGY

Differential Expression of MicroRNAs in CD34+ Cells of 5q- Syndrome

(2011) Hana Votavova et al.   Journal of Hematology & Oncology

Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic Study of 277 patients

(2011) M M Patnaik et al.   LEUKEMIA

Deregulation of microRNAs in myelodysplastic syndrome

(2011) G W Rhyasen et al.   LEUKEMIA

Recurrent DNMT3A mutations in patients with myelodysplastic syndromes

(2011) M J Walter et al.   LEUKEMIA

Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias

(2011) R Itzykson et al.   LEUKEMIA

DNMT3a mutations in high-risk myelodysplastic syndrome parallel those found in acute myeloid leukemia

(2011) M Ewalt et al.   Blood Cancer Journal

Genetics of Myelodysplastic Syndromes: New Insights

(2011) T. Graubert et al.   Hematology-American Society of Hematology Education Program

Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring

(2010) Feng Xu et al.   ANNALS OF HEMATOLOGY

Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value

(2010) A. E. Smith et al.   BLOOD

Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias

(2010) Julien Rocquain et al.   BMC CANCER

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Distinctive microRNA expression profiles in CD34+ bone marrow cells from patients with myelodysplastic syndrome

(2010) Michaela Dostalova Merkerova et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis

(2010) F. Thol et al.   HAEMATOLOGICA

A nonsense mutation of IDH1 in myelodysplastic syndromes and related disorders

(2010) K Yoshida et al.   LEUKEMIA

Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies

(2010) H Makishima et al.   LEUKEMIA

Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms

(2010) O Kosmider et al.   LEUKEMIA

Hematopoiesis-related microRNA expression in myelodysplastic syndromes

(2010) Aina Pons et al.   LEUKEMIA & LYMPHOMA

Aberrant microRNA expression pattern in myelodysplastic bone marrow cells

(2010) Kais Hussein et al.   LEUKEMIA RESEARCH

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

(2010) Myunggon Ko et al.   NATURE

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

(2010) Gorica Nikoloski et al.   NATURE GENETICS

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

(2010) Thomas Ernst et al.   NATURE GENETICS

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Array-based genomic resequencing of human leukemia

(2010) Y Yamashita et al.   ONCOGENE

Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome

(2010) J. Dickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs)

(2009) O. Kosmider et al.   BLOOD

Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms

(2009) A. M. Jankowska et al.   BLOOD

MicroRNA 29b functions in acute myeloid leukemia

(2009) R. Garzon et al.   BLOOD

MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation

(2009) M. E. Figueroa et al.   BLOOD

The role of microRNAs in normal and malignant hematopoiesis

(2009) Diamantina Vasilatou et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Novel TET2 Mutations Associated With UPD4q24 in Myelodysplastic Syndrome

(2009) Azim M. Mohamedali et al.   JOURNAL OF CLINICAL ONCOLOGY

Epigenetic Therapies Move Into New Territory, but How Exactly Do They Work?

(2009) R. S. Tuma   JNCI-Journal of the National Cancer Institute

Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

(2009) Pierre Fenaux et al.   LANCET ONCOLOGY

Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome

(2009) Kais Hussein et al.   LEUKEMIA RESEARCH

CpG methylation analysis of the MEG3 and SNRPN imprinted genes in acute myeloid leukemia and myelodysplastic syndromes

(2009) Leonidas Benetatos et al.   LEUKEMIA RESEARCH

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Acquired mutations in TET2 are common in myelodysplastic syndromes

(2009) Saskia M C Langemeijer et al.   NATURE GENETICS

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

Mutation inTET2in Myeloid Cancers

(2009) François Delhommeau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE