Article
Environmental Sciences
Yali Zhang, Xing Fan, Zhangyao Su, Tianli Yuan, Haimeng Yin, Haohao Gu, Yue Zuo, Shiyin Chen, Hongyu Zhou, Gaoxing Su
Summary: Metformin effectively prevents tau hyperphosphorylation caused by MC-LR, improving the AD-like phenotype. This preventive effect is mainly mediated by mTOR-dependent PP2A and GSK-3 beta activation.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Csongor Freytag, Csaba Mathe, Gabor Rigo, Tomasz Nodzynski, Zoltan Konya, Ferenc Erdodi, Agnes Cseplo, Erik Pozer, Laszlo Szabados, Adrienn Kelemen, Gabor Vasas, Tamas Garda
Summary: MCY-LR affects root development in Arabidopsis by altering PIN and auxin levels, providing insights into the phytotoxicity mechanism of MCY-LR in aquatic ecosystems. The study revealed the adverse effects of MCY-LR on PIN and auxin distribution in plant roots.
Article
Food Science & Technology
Yanfang Qian, Chenying Shi, Chen Cheng, Dengwei Liao, Junping Liu, Guitang Chen
Summary: This study demonstrates that ginger polysaccharide UGP1 can suppress the growth of colon cancer by inducing apoptosis and regulating immune system activity.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Review
Pharmacology & Pharmacy
Alakananda Basu
Summary: The interplay between apoptosis and senescence is crucial in cancer development, and targeting the Bcl-2 family proteins could be a promising strategy for cancer therapy. Therapy-induced senescence (TIS), induced by chemotherapeutic agents, has been controversial in its effect on therapeutic outcome. Clearance of senescent cells and overcoming their pro-survival mechanisms are important challenges in cancer treatment. This review article discusses recent literature on the role of the Bcl-2 family proteins in apoptosis and senescence, and the progress and limitations in targeting them for cancer therapy.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Environmental Sciences
Yuning Zhang, Jiancao Gao, Zhijuan Nie, Haojun Zhu, Jinliang Du, Liping Cao, Nailin Shao, Yi Sun, Shengyan Su, Gangchun Xu, Pao Xu
Summary: This study assessed the toxicity of MC-LR to a freshwater crab and found that it caused oxidative stress and apoptosis, mediated through the mitochondrial pathway. The regulation of oxidative stress and apoptosis may play a crucial role in the hepatotoxicity of MC-LR.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Nanoscience & Nanotechnology
Soraia P. S. Fernandes, Petr Kovar, Milan Psenicka, Artur M. S. Silva, Laura M. Salonen, Begona Espina
Summary: This study investigated the adsorption performance of three COFs for different MC derivatives, revealing different adsorption efficiencies for different toxins. By selecting COF functional groups, specific compounds can be selectively targeted or excluded, providing insights for the design of more efficient and selective adsorbent materials.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Lisenn Lalier, Francois Vallette, Stephen Manon
Summary: This review examines the role of mitochondrial import machineries in the localization of Bcl-2 family members and how these machineries regulate the function of pro- and anti-apoptotic proteins in resting and apoptotic cells.
Article
Pharmacology & Pharmacy
Jie Wang, Yan Ren, Xiufen Zheng, Jiaqi Kang, Zhenqian Huang, Lizhi Xu, Yaping Wang
Summary: This study demonstrated the anti-fibrotic effect of microcystin-RR on bleomycin-induced pulmonary fibrosis rodent models, attenuating pulmonary inflammation, collagen deposition, and fibrotic markers expression. Microcystin-RR treatment also reduced the number of pulmonary M2 macrophages and inhibited epithelial-mesenchymal transition and fibroblast-myofibroblast transition triggered by M2 macrophages. These findings suggest that microcystin-RR is a promising candidate for therapeutic and prophylactic strategies against idiopathic pulmonary fibrosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Daniel Barriuso, Lucia Alvarez-Frutos, Lucia Gonzalez-Gutierrez, Omar Motino, Guido Kroemer, Roberto Palacios-Ramirez, Laura Senovilla
Summary: The Bcl-2 family of proteins, known for regulating apoptosis, is also involved in cellular senescence. These proteins play a role in determining the entry into senescence and the expression levels are modulated during senescence, promoting cell survival. Manipulation of Bax and Bcl-2 expression affects the appearance and survival of tetraploid cells. Understanding the role of Bcl-2 family proteins in senescence can lead to new therapeutic strategies for targeting cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Elisabetta Valentini, Simona D'Aguanno, Marta Di Martile, Camilla Montesano, Virginia Ferraresi, Alexandros Patsilinakos, Manuela Sabatino, Lorenzo Antonini, Martina Chiacchiarini, Sergio Valente, Antonello Mai, Gianni Colotti, Rino Ragno, Daniela Trisciuoglio, Donatella Del Bufalo
Summary: Bcl-2 family anti-apoptotic proteins play a significant role in cancer, and finding new molecules targeting these proteins has therapeutic potential. Through virtual screening and experimental validation, IS20 and IS21 were identified as compounds that can inhibit the activity of Bcl-2 family proteins and have anti-proliferative and pro-apoptotic effects on various tumors.
Article
Biochemistry & Molecular Biology
Hector Flores-Romero, Lisa Hohorst, Malina John, Marie-Christine Albert, Louise E. King, Laura Beckmann, Tamas Szabo, Vanessa Hertlein, Xu Luo, Andreas Villunger, Lukas P. Frenzel, Hamid Kashkar, Ana J. Garcia-Saez
Summary: This study reveals a previously unrecognized activity of tBID in mediating mitochondrial permeabilization independently of BAX and BAK, which has physiological relevance in immune response and cancer therapy. This novel function of tBID is dependent on a specific helix structure and can be blocked by anti-apoptotic proteins, providing potential implications for therapeutic intervention in bacterial infections and cancer treatment.
Article
Environmental Sciences
Sijia Hua, Jiawen Chen, Liang Wu, Xinyue Yu, Jing Ye, Yuanting Li, Yongqiang Zhu, Fuxiang Tian
Summary: This study detected the contents of MC-LR in Microcystis aeruginosa cultures and water samples from the Huangpu River using ELISA and HPLC methods. The results showed that ELISA was a reliable and simple method for monitoring low levels of MC-LR. The concentration of MC-LR in the Huangpu River varied with the season, but remained below the WHO drinking water quality standard.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Xingde Du, Haohao Liu, Xiaohui Liu, Xinghai Chen, Le Yuan, Ya Ma, Hui Huang, Yueqin Wang, Rui Wang, Shiyu Zhang, Zhihui Tian, Linjia Shi, Huizhen Zhang
Summary: The research has revealed the significant role of ASK1 in MC-LR-induced ovarian injury and apoptosis. Inhibiting ASK1 expression effectively alleviated MC-LR-induced ovarian cell damage, providing new insights for preventing female reproductive toxicity induced by MCs.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Chathura D. Suraweera, Suresh Banjara, Mark G. Hinds, Marc Kvansakul
Summary: The B-cell lymphoma-2 (Bcl-2) family of genes regulates intrinsic apoptosis by coordinating the integrity of the mitochondrial outer membrane. Bcl-2 genes are present in early metazoans and have different variations among species. The structure of Bcl-2 proteins is highly conserved over evolutionary time, and some Bcl-2 proteins may have non-apoptotic functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Cheng Chi, Sib Sankar Giri, Xia Wei Yu, Yuan Liu, Ke Ke Chen, Wen Bin Liu, Ding Dong Zhang, Guang Zhen Jiang, Xiang Fei Li, Xin Gao, Bin Lin Chen, Se Chang Park
Summary: Global warming increases harmful cyanobacterial blooms, and microcystin-LR (MC-LR) is a hepatotoxic agent produced during these blooms. This study injected different doses of MC-LR into the hepatopancreas of Chinese mitten crab and found that it affected gene expression, leading to triglyceride accumulation and changes in sterol metabolism, apoptosis, and actin cytoskeleton regulation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)