Pretreatment with metformin prevents microcystin‐LR ‐induced tau hyperphosphorylation via mTOR ‐dependent PP2A and GSK ‐3β activation

Metformin Inhibit Lung Cancer Cell Growth and Invasion in Vitro as Well as Tumor Formation in Vivo Partially by Activating PP2A

(2019) Xiaohu Zhou et al.   MEDICAL SCIENCE MONITOR

Learning and memory deficits and Alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR

(2019) Jing Wang et al.   JOURNAL OF HAZARDOUS MATERIALS

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

(2019) Mohamed Elgendy et al.   CANCER CELL

Centella asiatica Protects d-Galactose/AlCl3 Mediated Alzheimer’s Disease-Like Rats via PP2A/GSK-3β Signaling Pathway in Their Hippocampus

(2019) Samaila Musa Chiroma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective role of metformin against methamphetamine induced anxiety, depression, cognition impairment and neurodegeneration in rat: The role of CREB/BDNF and Akt/GSK3 signaling pathways

(2019) Saghar Keshavarzi et al.   NEUROTOXICOLOGY

The protective effect of metformin in scopolamine-induced learning and memory impairment in rats

(2019) Elif Aksoz et al.   Pharmacological Reports

Metformin Improves Learning and Memory in the SAMP8 Mouse Model of Alzheimer’s Disease

(2019) Susan A. Farr et al.   JOURNAL OF ALZHEIMERS DISEASE

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

(2018) Zhenri Ou et al.   BRAIN BEHAVIOR AND IMMUNITY

The differential effects of microcystin-LR on mitochondrial DNA in the hippocampus and cerebral cortex

(2018) Xiaofen Wang et al.   ENVIRONMENTAL POLLUTION

Effect of tibolone pretreatment on kinases and phosphatases that regulate the expression and phosphorylation of Tau in the hippocampus of rats exposed to ozone

(2018) Christian Guerra-Araiza et al.   Neural Regeneration Research

Microcystin-Leucine-Arginine Induces Tau Pathology Through Bα Degradation via Protein Phosphatase 2A Demethylation and Associated Glycogen Synthase Kinase-3β Phosphorylation

(2018) Yali Zhang et al.   TOXICOLOGICAL SCIENCES

The Therapeutic Potential of Metformin in Neurodegenerative Diseases

(2018) Carola Rotermund et al.   Frontiers in Endocrinology

Microcystin-leucine arginine inhibits gonadotropin-releasing hormone synthesis in mice hypothalamus

(2018) Jing Wang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Environmental Microcystin Exposure Increases Liver Injury Risk Induced by Hepatitis B Virus Combined with Aflatoxin: A Cross-Sectional Study in Southwest China

(2017) Wenyi Liu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Serum microcystin levels positively linked with risk of hepatocellular carcinoma: A case-control study in southwest China

(2017) Chuanfen Zheng et al.   HEPATOLOGY

Metformin lowers α-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson's disease

(2017) Nikita Katila et al.   NEUROPHARMACOLOGY

The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia

(2017) Giusy Di Conza et al.   Cell Reports

Metformin induces degradation of cyclin D1 via AMPK/GSK3β axis in ovarian cancer

(2016) HyeRan Gwak et al.   MOLECULAR CARCINOGENESIS

Metformin Prevented Dopaminergic Neurotoxicity Induced by 3,4-Methylenedioxymethamphetamine Administration

(2016) Pier Francesca Porceddu et al.   NEUROTOXICITY RESEARCH

Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State

(2016) Francesca Sacco et al.   Cell Systems

Erratum: Corrigendum: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

(2015) Valentina Cianfanelli et al.   NATURE CELL BIOLOGY

Pharmacodynamic Monitoring of Mammalian Target of Rapamycin Inhibition by Phosphoflow Cytometric Determination of p70S6 Kinase Activity

(2015) André Hoerning et al.   TRANSPLANTATION

The role of calcineurin signaling in microcystin-LR triggered neuronal toxicity

(2015) Guangyu Li et al.   Scientific Reports

Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation

(2014) B I Pérez-Revuelta et al.   Cell Death & Disease

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

(2013) Antonella Caccamo et al.   AGING CELL

Activator or inhibitor? GSK-3 as a new drug target

(2013) Fumi Takahashi-Yanaga   BIOCHEMICAL PHARMACOLOGY

Tau phosphorylation and neuronal apoptosis induced by the blockade of PP2A preferentially involve GSK3β

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Microcystin-LR induces cytoskeleton system reorganization through hyperphosphorylation of tau and HSP27 via PP2A inhibition and subsequent activation of the p38 MAPK signaling pathway in neuroendocrine (PC12) cells

(2011) Guanmin Meng et al.   TOXICOLOGY

Investigation of Microcystin Congener–Dependent Uptake into Primary Murine Neurons

(2010) Daniel Feurstein et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Metabolic Regulation of Neuronal Plasticity by the Energy Sensor AMPK

(2010) Wyatt B. Potter et al.   PLoS One

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA