Article
Biology
Cong Liu, Milena Schonke, Borah Spoorenberg, Joost M. Lambooij, Hendrik J. P. van der Zande, Enchen Zhou, Maarten E. Tushuizen, Anne-Christine Andreasson, Andrew Park, Stephanie Oldham, Martin Uhrbom, Ingela Ahlstedt, Yasuhiro Ikeda, Kristina Wallenius, Xiao-Rong Peng, Bruno Guigas, Mariëtte R. Boon, Yanan Wang, Patrick C. N. Rensen
Summary: Analogues of FGF21 have shown protective effects on NASH by reducing hepatic lipotoxicity, inflammation, and fibrogenesis. Increasing the production of FGF21 prevents diet-induced obesity and NASH in mice fed a high-fat diet. This study provides a new approach for the treatment of liver diseases.
Article
Multidisciplinary Sciences
Panu K. Luukkonen, Ikki Sakuma, Rafael C. Gaspar, Meghan Mooring, Ali Nasiri, Mario Kahn, Xian-Man Zhang, Dongyan Zhang, Henna Sammalkorpi, Anne K. Penttilae, Marju Orho-Melander, Johanna Arola, Anne Juuti, Xuchen Zhang, Dean Yimlamai, Hannele Yki-Jaervinen, Kitt Falk Petersen, Gerald I. Shulman
Summary: The HSD17B13 rs72613567-A variant is associated with a reduced risk of liver fibrosis in nonalcoholic fatty liver disease (NAFLD). The protective effect is related to decreased pyrimidine catabolism mediated by dihydropyrimidine dehydrogenase. Inhibition of pyrimidine catabolism could mimic the protective effect of HSD17B13, suggesting it as a potential therapeutic target against liver fibrosis in NAFLD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Qiang Qin, Jia'nan Shou, Mengjie Li, Meidi Gu, Zhuoxian Meng, Pinglong Xu, Hua Meng, Xiaojian Wang
Summary: In this study, it was found that the expression of Stk24 is significantly downregulated in ATMs in obese individuals or those with type 2 diabetes, as well as in mice fed a high-fat diet. Stk24 deficiency exacerbates HFD-induced metabolic disorders and insulin insensitivity. Stk24 plays a role in regulating NLRP3 inflammasome assembly in ATMs, and its expression correlates negatively with body mass index and related indicators in human subjects.
Article
Biochemistry & Molecular Biology
Tianxing Chen, Yao Meng, Zhihang Zhou, Haitao Li, Lingfeng Wan, Aiwen Kang, Wei Guo, Ke Ren, Xueru Song, Yu Chen, Wei Zhao
Summary: This study reveals the significance of the GAS5/miR-28a-5p/MARCH7/NLRP3 axis in the development of nonalcoholic fatty liver disease (NAFLD). GAS5 protects against NAFLD by binding to miR-28a-5p, while miR-28a-5p promotes NAFLD by targeting MARCH7. MARCH7 ameliorates NAFLD by suppressing NLRP3-mediated pyroptosis.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Endocrinology & Metabolism
Yinhua Ni, Fen Zhuge, Liyang Ni, Naoto Nagata, Tatsuya Yamashita, Naofumi Mukaida, Shuichi Kaneko, Tsuguhito Ota, Mayumi Nagashimada
Summary: This study investigates the roles of CX3CL1/CX3CR1 in macrophage migration and polarization in the livers of NASH mice. It is found that CX3CL1 and CX3CR1 expression is upregulated in NASH mice livers, and CX3CR1 is predominantly expressed by F4/80+ macrophages. CX3CR1 deficiency leads to increased inflammatory monocyte/macrophage infiltration and a shift towards M1 dominant macrophages, exacerbating NASH progression. Deletion of CCL2 in CX3CR1-deficient mice alleviates NASH progression by reducing macrophage infiltration and inducing a shift towards M2 dominant macrophages.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Endocrinology & Metabolism
Xiaoying Liu, Bu B. Yeap, Kaye E. Brock, Itamar Levinger, Jonathan Golledge, Leon Flicker, Tara C. Brennan-Speranza
Summary: The study found that lower levels of serum ucOC and cOC, as well as %cOC, were associated with less favorable metabolic parameters and a higher risk of MetS. Conversely, a lower proportion of ucOC was linked to better metabolic parameters and reduced risk of MetS. Further research is needed to determine if ucOC and cOC are suitable biomarkers for cardiometabolic risk in men.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Xiaoying Liu, Bu B. Yeap, Kaye E. Brock, Itamar Levinger, Jonathan Golledge, Leon Flicker, Tara C. Brennan-Speranza
Summary: The study demonstrated that lower levels of serum ucOC or cOC were associated with less favorable metabolic parameters and a higher risk of MetS, while a lower proportion of ucOC was associated with better metabolic parameters and lower MetS risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Chemistry, Medicinal
Tingjun Xu, Wenxing Gao, Lixin Zhu, Wanning Chen, Chaoqun Niu, Wenjing Yin, Liangxiao Ma, Xinyue Zhu, Yunchao Ling, Sheng Gao, Lei Liu, Na Jiao, Weiming Chen, Guoqing Zhang, Ruixin Zhu, Dingfeng Wu
Summary: NAFLDkb is a specialized knowledge base and platform for computer-aided drug design against nonalcoholic fatty liver disease (NAFLD). It provides associations of drug-related entities as individual knowledge graphs, using curated information from diverse source materials and public databases. Practical drug discovery tools, including chemical structure search, drug-likeness screening, knowledge-based repositioning, and research article annotation, are implemented in the web interface. Case studies demonstrate the clinical reliability and potential of NAFLDkb in identifying novel drug-disease associations and accelerating NAFLD drug development. NAFLDkb is freely accessible at https://www.biosino.org/nafldkb and regularly updated with the latest findings.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Nutrition & Dietetics
Mahsa Yavari, Latha Ramalingam, Breanna N. Harris, Chanaka Nadeeshan Kahathuduwa, Angela Chavira, Caroline Biltz, Logan Mounce, Kaylee Alers Maldonado, Shane Scoggin, Yujiao Zu, Nishan Sudheera Kalupahana, Mohammad Yosofvand, Hanna Moussa, Naima Moustaid-Moussa
Summary: This study aimed to determine whether EPA reduces obesity-associated metabolic dysfunctions and amyloid-l3 accumulation in AD amyloidogenic mice. The results showed that EPA can improve the metabolic condition of obese AD male mice by reducing serum amyloid levels.
JOURNAL OF NUTRITION
(2023)
Article
Immunology
Hussein Hamade, Jasmine T. Stamps, Dalton T. Stamps, Shyam K. More, Lisa S. Thomas, Anna Y. Blackwood, Nawele L. Lahcene, Sofi L. Castanon, Brenda C. Salumbides, Yosuke Shimodaira, Helen S. Goodridge, Stephan R. Targan, Kathrin S. Michelsen
Summary: Intestinal dendritic cells play an important role in metabolic syndrome by preserving beneficial microbiota and maintaining intestinal epithelial barrier function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Xin Zhang, Hailong Yang, Shan Zeng, Song Tian, Sha Hu, Ling Yang, Tengfei Ma, Zhen Liu, Juan Wan, Yiming Zhong, Hongliang Li
Summary: Background and Aims NASH is characterized by hepatocyte abnormalities and inflammation. Innate immunity is believed to play a crucial role in NASH. This study found that MDA5 can suppress NASH progression by regulating the ASK1-mitogen-activated protein kinase pathway, making it a potential therapeutic target for NASH.
Article
Pharmacology & Pharmacy
Panshuang Qiao, Yingli Jia, Ang Ma, Jinzhao He, Chen Shao, Xiaowei Li, Shuyuan Wang, Baoxue Yang, Hong Zhou
Summary: This study suggests that dapagliflozin, an insulin-independent hypoglycemic drug, may improve nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Dapagliflozin reduces lipid accumulation, inflammation, and fibrosis in the liver, providing new insights for understanding the protective effect of this drug in NASH.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Souradipta Ganguly, German A. Eman Muench, Linshan Shang, Sara Brin Rosenthal, Gibraan Rahman, Ruoyu Wang, Yanhan Wang, Hyeok Choon Kwon, Anthony M. Diomino, Tatiana Kisseleva, Pejman Soorosh, Mojgan Hosseini, Rob Knight, Bernd Schnabl, David A. Brenner, Debanjan Dhar
Summary: Using a hyperphagic mouse model fed with a Western diet closely mimics the pathobiology and gene signature of human NASH with fibrosis and subsequent HCC. The progression from NASH to cirrhosis and HCC is dependent on diet, and switching back to a normal diet can lead to regression of NASH and improved survival.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Claire Mayer, Leo Richard, Martine Come, Lionel Ulmann, Hassan Nazih, Benoit Chenais, Khadija Ouguerram, Virginie Mimouni
Summary: The study demonstrated that the DHA-rich microalga Tisochrysis lutea can improve metabolic disturbances associated with obesity, enhance lipid and glucose metabolism, reduce fat accumulation and inflammation.
Article
Chemistry, Medicinal
Liang Dai, Qian Wang, Pengfei Wang, Shangran Zhang, Luyang Tai, Xiangrui Xu, Gang Sun, Mengyu Duan, Haoliang Yuan, Zhiqi Feng
Summary: Nonalcoholic steatohepatitis (NASH) is a growing public health burden with no effective therapeutic drugs. Sustained hepatic inflammation is the key histopathological feature of NASH. Researchers have discovered that the novel AdipoRon analogue Q7 exhibits potent anti-inflammatory activity and low cytotoxicity. In animal experiments, Q7 demonstrated superior anti-inflammatory, anti-fibrotic, and lipid-lowering effects compared to AdipoRon. Q7 shows promise as a potential anti-inflammatory and anti-NASH agent.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Geriatrics & Gerontology
Katarzyna A. Cieslik, Rajagopal V. Sekhar, Alejandro Granillo, Anilkumar Reddy, Guillermo Medrano, Celia Pena Heredia, Mark L. Entman, Dale J. Hamilton, Shumin Li, Erin Reineke, Anisha A. Gupte, Aijun Zhang, George E. Taffet
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2018)
Article
Chemistry, Multidisciplinary
Suhong Wu, Aijun Zhang, Shumin Li, Somik Chatterjee, Ruogu Qi, Victor Segura-Ibarra, Mauro Ferrari, Anisha Gupte, Elvin Blanco, Dale J. Hamilton
Article
Surgery
Christine A. Beamish, A. Osama Gaber, Solmaz F. Afshar, Daniel W. Fraga, Dale J. Hamilton, Omaima M. Sabek
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Cell Biology
Xingzhe Ma, Enguang Bi, Yong Lu, Pan Su, Chunjian Huang, Lintao Liu, Qiang Wang, Maojie Yang, Matthew F. Kalady, Jianfei Qian, Aijun Zhang, Anisha A. Gupte, Dale J. Hamilton, Chengyun Zheng, Qing Yi
Article
Pharmacology & Pharmacy
Haoran Zhang, Aijun Zhang, Anisha A. Gupte, Dale J. Hamilton
Summary: The study reveals the relationship between metabolism and cytotoxic effects of PLB in melanoma, indicating PLB displays stronger cytotoxic effects on A375 cells and triggers cell-specific metabolic changes in accordance with its cytotoxic effects.
Article
Biochemistry & Molecular Biology
Sivareddy Kotla, Aijun Zhang, Masaki Imanishi, Kyung Ae Ko, Steven H. Lin, Young Jin Gi, Margie Moczygemba, Sevinj Isgandarova, Keri L. Schadler, Caroline Chung, Sarah A. Milgrom, Jose Banchs, Syed Wamique Yusuf, Diana N. Amaya, Huifang Guo, Tamlyn N. Thomas, Ying H. Shen, Anita Deswal, Joerg Herrmann, Eugenie S. Kleinerman, Mark L. Entman, John P. Cooke, Giovanni Schifitto, Sanjay B. Maggirwar, Elena McBeath, Anisha A. Gupte, Sunil Krishnan, Zarana S. Patel, Yisang Yoon, Jared K. Burks, Keigi Fujiwara, Paul S. Brookes, Nhat-Tu Le, Dale J. Hamilton, Jun-ichi Abe
Summary: The incidence of cardiovascular disease is higher in cancer survivors due to various cancer treatments. Research suggests that chemotherapy and radiation therapy can induce persistent SASP, a phenotype associated with cardiovascular disease. Inhibiting PARP activation may prevent the development of cardiovascular disease in cancer survivors.
Review
Biochemistry & Molecular Biology
Haoran Zhang, Zhe Chen, Aijun Zhang, Anisha A. Gupte, Dale J. Hamilton
Summary: Calcium signaling plays crucial roles in the development and progression of cutaneous melanoma. It affects melanogenesis, the tumor microenvironment, and can be targeted for therapeutic intervention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Aijun Zhang, Anisha A. Gupte, Somik Chatterjee, Shumin Li, Alberto G. Ayala, Brian J. Miles, Dale J. Hamilton
Summary: The transformation of prostatic epithelial cells to prostate cancer is associated with metabolic changes and enhanced mitochondrial respiratory flux. Declining mitochondrial zinc concentrations are believed to be the molecular mechanism for this transformation. Indirect evidence based on pre-clinical models, cell lines, and tissue samples has supported the unique metabolic properties of prostate cancer cells, but direct respiratory analysis on fresh human tissue remains difficult.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jun-Dae Kim, Teng Zhou, Aijun Zhang, Shumin Li, Anisha A. Gupte, Dale J. Hamilton, Longhou Fang
Summary: This study reveals a new role of NAXE in cardiac ketone and lipid metabolism. NAXE knockout increases ketone body levels and lipid-associated metabolites while reducing cardiac lactic acid. However, it has no effect on other NAD(P)H-regulated metabolites.
Article
Cardiac & Cardiovascular Systems
Jun-ichi Abe, Masaki Imanishi, Shengyu Li, Aijun Zhang, Kyung Ae Ko, Venkata S. K. Samanthapudi, Ling-Ling Lee, Angelica Paniagua Bojorges, Young Jin Gi, Brian P. P. Hobbs, Anita Deswal, Joerg Herrmann, Steven H. H. Lin, Eduardo N. N. Chini, Ying H. H. Shen, Keri L. L. Schadler, Thi-Hong-Minh Nguyen, Anisha A. A. Gupte, Cielito Reyes-Gibby, Sai-Ching J. Yeung, Rei J. J. Abe, Elizabeth A. A. Olmsted-Davis, Sunil Krishnan, Robert Dantzer, Nicolas L. L. Palaskas, John P. P. Cooke, Henry J. J. Pownall, Momoko Yoshimoto, Keigi Fujiwara, Dale J. J. Hamilton, Jared K. K. Burks, Guangyu Wang, Nhat-Tu Le, Sivareddy Kotla
Summary: The phosphorylation of ERK5 S496 mediates inflammatory responses in atherosclerosis by upregulating AHR and inhibiting NRF2 transcriptional activity. It also induces senescence-associated secretory phenotype and stemness phenotype in macrophages, leading to atherogenesis.
CIRCULATION RESEARCH
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Sivareddy Kotla, Masaki Imanishi, Shengyu Li, Aijun Zhang, Kyung A. Ko, Venkata Subrahman K. Samanthapudi, Ling-Ling Lee, Joerg Herrmann, Steven Lin, Michael N. Shoykhet, Ying H. Shen, Keri Schadler, Minh T. Nguyen, Anisha A. Gupte, Cielito Reyes-Gibby, Sai-Ching Yeung, Nicolas L. Palaskas, John P. Cooke, Henry J. Pownall, Momoko Yoshimoto, Keigi Fujiwra
Meeting Abstract
Cardiac & Cardiovascular Systems
Khanh Chau, Masaki Imanishi, Shengyu Li, Sivareddy Kotla, Kyung A. Ko, Minh T. Nguyen, Estefani Berrios Turcios, Rei Abe, Aijun Zhang, Elena McBeath, Keigi Fujiwara, Young Jin Gi, Kyung-Sun Heo, Jinke Cheng, Tamlyn Thomas, Keri Schadler, Anisha A. Gupte, Ying H. Shen, Steven Lin, Edward T. Yeh, Keigi Fujiwra, Dale Hamilton, John P. Cooke, Guangyu Wang
Meeting Abstract
Urology & Nephrology
Brian Miles, Aijun Zhang, Somik Chatterjeee, Indira Vedula, Anisha Gupte, Alberto Ayala, Dale Hamilton
JOURNAL OF UROLOGY
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
Somik Chatterjee, Li Shumin, Zhang Aijun, Indira Vedula, Judy A. AlRukby, Dale J. Hamilton, Anisha A. Gupte
CIRCULATION RESEARCH
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Sivareddy Kotla, Aijun Zhang, Kyung Ae Ko, Masaki Imanishi, Hira Mazhar, Tamlyn Thomas, Young Gi, Hang Vu, Elena McBeath, Steven Lin, Eugenie Kleinerman, Keri Schadler, Keigi Fujiwara, Anisha Gupte, Nhat-tu Le, Dale Hamilton, Sunil Krishnan, Junichi Abe
FREE RADICAL BIOLOGY AND MEDICINE
(2019)