Pharmacogenetics of drug-induced liver injury

Influence of glutathione S-transferase M1 and T1 homozygous null mutations on the risk of antituberculosis drug-induced hepatotoxicity in a Caucasian population

(2010) Virginia Leiro et al.   LIVER INTERNATIONAL

Pharmacogenetics: from discovery to patient care

(2009) Jaekyu Shin et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

A systems biology approach to understanding elevated serum alanine transaminase levels in a clinical trial with ximelagatran

(2009) Ulf Andersson et al.   BIOMARKERS

Impact of OATP transporters on pharmacokinetics

(2009) A Kalliokoski et al.   BRITISH JOURNAL OF PHARMACOLOGY

Current Concepts of Mechanisms in Drug-Induced Hepatotoxicity

(2009) Stefan Russmann et al.   CURRENT MEDICINAL CHEMISTRY

Genetic Variations of the ABC Transporter Gene ABCB11 Encoding the Human Bile Salt Export Pump (BSEP) in a Japanese Population

(2009) Su-Ryang Kim et al.   Drug Metabolism and Pharmacokinetics

Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans

(2009) A. H. Harrill et al.   GENOME RESEARCH

Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events

(2009) Craig Lammert et al.   HEPATOLOGY

Hepatic OATP1B Transporters and Nuclear Receptors PXR and CAR: Interplay, Regulation of Drug Disposition Genes, and Single Nucleotide Polymorphisms

(2009) Henriette E. Meyer zu Schwabedissen et al.   MOLECULAR PHARMACEUTICS

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Genomewide Association Studies and Human Disease

(2009) John Hardy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s

(2008) Bo Wen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Bioactivation of Flutamide Metabolites by Human Liver Microsomes

(2008) P. Kang et al.   DRUG METABOLISM AND DISPOSITION

Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3

(2008) Chunshan Gui et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Severe Bile Salt Export Pump Deficiency: 82 Different ABCB11 Mutations in 109 Families

(2008) Sandra S. Strautnieks et al.   GASTROENTEROLOGY

Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States

(2008) Naga Chalasani et al.   GASTROENTEROLOGY

Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy

(2008) P H Dixon et al.   GUT

GlutathioneS-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury

(2008) M. Isabel Lucena et al.   HEPATOLOGY

Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: Search for signals

(2008) Craig Lammert et al.   HEPATOLOGY

Haplotypic analysis of Wellcome Trust Case Control Consortium data

(2008) Brian L. Browning et al.   HUMAN GENETICS

Practical aspects of imputation-driven meta-analysis of genome-wide association studies

(2008) P. I.W. de Bakker et al.   HUMAN MOLECULAR GENETICS

Analysis of IL-10, IL-4 and TNF-α polymorphisms in drug-induced liver injury (DILI) and its outcome

(2008) Ketevan Pachkoria et al.   JOURNAL OF HEPATOLOGY

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

HLA-B*5701 Screening for Hypersensitivity to Abacavir

(2008) Simon Mallal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney

(2008) Zoulikha M Zaïr et al.   PHARMACOGENOMICS

Genome-wide approaches to identify pharmacogenetic contributions to adverse drug reactions

(2008) M R Nelson et al.   PHARMACOGENOMICS JOURNAL

The Role of FXR in Disorders of Bile Acid Homeostasis

(2008) Jyrki J. Eloranta et al.   PHYSIOLOGY

Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump

(2008) Yvonne Meier et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family

(2008) B. Hagenbuch et al.   XENOBIOTICA

CYP2E1 and oxidative liver injury by alcohol

(2007) Yongke Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans

(2007) Peter Kovacs et al.   JOURNAL OF HEPATOLOGY

The Nrf2–Keap1 defence pathway: Role in protection against drug-induced toxicity

(2007) Ian M. Copple et al.   TOXICOLOGY