Review
Biochemistry & Molecular Biology
Yuliya Markina, Tatiana Kirichenko, Alexander M. Markin, Irina Y. Yudina, Antonina Starodubova, Igor A. Sobenin, Alexander N. Orekhov
Summary: Cardiovascular diseases associated with atherosclerosis are the leading cause of death in developed countries. Licorice has shown promising anti-atherosclerotic effects, including anti-inflammatory, antioxidant, and anti-platelet actions, making it a potential atheroprotective agent.
Article
Plant Sciences
Zihui Shen, Xiaojiao Cheng, Xiao Li, Xianya Deng, Xiuxiu Dong, Shaoming Wang, Xiaozhen Pu
Summary: The foliar application of silicon can enhance salt tolerance in licorice, improve water absorption and photosynthesis, promote growth and yield, and alleviate the adverse effects of salt stress on leaf structure.
Article
Chemistry, Multidisciplinary
Zi-Long Wang, Jia-Jing Zhou, Bo-Yun Han, Aobulikasimu Hasan, Ya-Qun Zhang, Jia-He Zhang, Hai-Dong Wang, Bin Li, Xue Qiao, Min Ye
Summary: In this study, a highly regio- and donor-specific enzyme GuRhaGT was isolated from the medicinal plant Glycyrrhiza uralensis, which efficiently catalyses the glycosylation reaction at the 2''-OH site of the C-3 glycosyl moiety of triterpenoid saponins.
CHEMICAL COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Tina Ghaffari, Nariman Moradi, Elham Chamani, Zahra Ebadi, Reza Fadaei, Shahin Alizadeh-Fanalou, Sahar Yarahmadi, Soudabeh Fallah
Summary: The present study investigated the effect of applying spironolactone and captopril and their combination on some renal performance indices and cholesterol-efflux-related gene expression in nephropathy diabetic rats. The results suggest that S+C combination therapy can improve nephropathy and diabetes disorders by targeting the ABCA1 and miR-33 gene expression.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Review
Medical Laboratory Technology
Zhaohui Cao, Di Huang, Cifei Tang, Yang Lu, Shuangxiang Huang, Cuiying Peng, Xiaobo Hu
Summary: This mini-review discusses the molecular mechanisms of inflammasome activation and pyroptosis, highlighting their crucial role in diabetic nephropathy (DN). Natural plant compounds show therapeutic potential in regulating inflammasomes and pyroptosis.
CLINICA CHIMICA ACTA
(2022)
Article
Acoustics
Romee Jan, Adil Gani, Mohd Masarat Dar, Naseer Ahmad Bhat
Summary: This study focused on extracting polyphenols from ginger and licorice using ultrasonication technique, with the best extraction efficiency observed in the aqueous phase. The extracts were found to contain various beneficial bioactive compounds, highlighting the potential of these herbs as natural antioxidants.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Plant Sciences
Sophie Hermann, Marc Orlik, Petra Boevink, Elke Stein, Andrea Scherf, Ina Kleeberg, Annegret Schmitt, Adam Schikora
Summary: The study demonstrates that licorice leaf extract can be an effective alternative to conventional pesticides, acting as a fungicide and bactericide and modulating the plant immune system to combat pathogen infections.
Article
Biochemistry & Molecular Biology
Hongtao Tan, Junxian Chen, Yicong Li, Yingshan Li, Yunchang Zhong, Guangzhao Li, Lingling Liu, Yiqun Li
Summary: Through network pharmacology, the study revealed the protective effects of Glab on diabetic nephropathy, possibly by suppressing ferroptosis and the VEGF/Akt/ERK pathway.
MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Jiangyi Zeng, Yun Huang, Lijun Zhou, Xiaoju Liang, Chao Yang, Hongxia Wang, Ling Yuan, Ying Wang, Yongqing Li
Summary: A histone deacetylase inhibitor was found to enhance the accumulation of LCA and total flavonoids in Glycyrrhiza inflata seedlings, suggesting a negative regulatory role of the targeted HDAC. Further analysis revealed an up-regulated O-methyltransferase gene that is important for LCA accumulation.
Article
Plant Sciences
Joji Abraham, Singarayer Florentine
Summary: Despite COVID-19 vaccination efforts, ongoing personal and social caution is necessary; pharmaceutical industry aims to develop antiviral and anti-inflammatory drugs to alleviate COVID-19 symptoms; research on licorice phytochemicals shows potential for natural interventions against COVID-19 symptoms.
Article
Environmental Sciences
Ibrahim M. Alhazza, Hossam Ebaid, Mohamed S. Omar, Iftekhar Hassan, Mohamed A. Habila, Jameel Al-Tamimi, Mohamed Sheikh
Summary: The study found that selenium nanoparticles (SeNPs) have a protective effect against kidney injury in streptozocin-induced diabetic rats, improving symptoms such as polyuria, delayed gestation, and abnormal pancreatic beta-cells.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
F. M. Reda, M. T. El-Saadony, T. K. El-Rayes, M. Farahat, G. Attia, M. Alagawany
Summary: The inclusion of licorice at levels of 750 and 1000 mg/kg into the diet of Japanese quails enhances the animals' performance, immunity, antioxidant capacity, and maintains a healthy gut microbiota.
Article
Plant Sciences
Dilfuza Egamberdieva, Hua Ma, Burak Alaylar, Zohreh Zoghi, Aida Kistaubayeva, Stephan Wirth, Sonoko Dorothea Bellingrath-Kimura
Summary: The addition of maize-derived biochar significantly improved the growth and nutrient uptake of licorice under saline soil conditions by promoting nodule formation and root architecture improvement, as well as positively impacting soil enzyme activity.
Review
Multidisciplinary Sciences
Md. Kamrul Hasan, Iffat Ara, Muhammad Shafiul Alam Mondal, Yearul Kabir
Summary: Nature is a great source of therapeutic compounds, with licorice being a medicinal herb that contains beneficial compounds with various pharmacological benefits.
Article
Plant Sciences
Seyyed Sasan Mousavi, Akbar Karami, Filippo Maggi
Summary: The study evaluated the effects of Azotobacter sp. inoculation on Iranian licorice plants under salt stress. The results showed that bacterial inoculation increased carotenoid content and mitigated salt stress. Anatomical observations of leaf structure revealed a decrease in stomatal density and an increase in trichome density under salt stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Letter
Endocrinology & Metabolism
Alaaeldin Ahmed Hamza
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2018)
Article
Pharmacology & Pharmacy
Fadia S. Youssef, Mohamed L. Ashour, Hesham A. El-Beshbishy, Alaaeldin Ahmed Hamza, Abdel Nasser B. Singab, Michael Wink
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Alaaeldin Ahmed Hamza, Fawzy Mohamed Lashin, Mona Gamel, Soha Osama Hassanin, Youssef Abdalla, Amr Amin
Article
Medicine, Research & Experimental
Alaaeldin Ahmed Hamza, Gehan Hussein Heeba, Salsabil Hamza, Ali Abdalla, Amr Amin
Summary: The study demonstrates that ginger has chemo-preventive effects against liver cancer by reducing carcinogenic changes, inducing apoptosis, and protecting the liver from oxidative and inflammatory damage. Ginger also inhibits cell proliferation and promotes cell death, showcasing its potential as a natural preventive agent for liver cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Alaaeldin Ahmed Hamza, Mohammad Ahmad Khasawneh, Hanan Mohamed Elwy, Soha Osama Hassanin, Sammar Fathy Elhabal, Nael M. Fawzi
Summary: The ethanolic extract of Salvadora persica L. fruits (SP) showed promising chemopreventive potential against DMBA-induced mammary carcinogenesis, suppressing tumor incidence, reducing cell proliferation, inducing apoptosis, and down-regulating estrogen receptor expression. Additionally, SP extract prevented oxidative damage and induced apoptosis and cell cycle arrest in MCF-7 breast cancer cells.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Youssef Abdalla, Ali Abdalla, Alaaeldin Ahmed Hamza, Amr Amin
Summary: This study found that safranal has chemopreventive effects against liver cancer and investigated its mechanisms of action. Safranal was found to significantly inhibit proliferation and induce apoptosis in both rat and human liver cancer cells, and it also exhibited anti-inflammatory properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Mohamed El-Kassas, Taymour Mostafa, Gamal Esmat, Samia A. Shouman, Naglaa Kholoussi, Adel M. Ashour, Alaaeldin Ahmed Hamza, Ahmed El-Sakka, Amr Radwan, Neveen A. Soliman, Karim Fawzy El-Sayed, Amal Mohktar, Sahar Zaghloul, Abdel Meguid Kassem, Mohamed Awad Tag Eldin
ARAB JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Nanoscience & Nanotechnology
Sammar Fathy ELhabal, Hanan Mohamed Elwy, Soha Hassanin, Ahmed A. El-Rashedy, Alaaeldin Ahmed Hamza, Mohammad Ahmad Khasawneh
Summary: Plant-mediated synthesis of metal nanoparticles is an eco-friendly, clean, and viable alternative to chemical and physical approaches.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Oncology
Basma Awad, Alaaeldin Ahmed Hamza, Amna Al-Maktoum, Suhail Al-Salam, Amr Amin
Summary: This study found that the combination of crocin and sorafenib yielded better results in inhibiting tumor growth compared to their individual use in a rat model of liver cancer. The combination therapy achieved this by suppressing inflammation, promoting apoptosis, and restoring liver morphology.
Article
Biology
Alaaeldin Ahmed Hamza, Mona Gamel, Ali Abdalla, Youssef Abdalla, Amr Amin
Summary: In this study, the hepatoprotective effects of Gentiana extract (GEN) against ketoconazole (KET)-induced hepatotoxicity were investigated in male Wistar rats. The results showed that GEN reduced liver damage induced by KET, as evidenced by decreased levels of aminotransferase and alpha-fetoprotein in serum and improved hepatic histopathological changes. Furthermore, GEN inhibited oxidative stress induced by KET by reducing lipid peroxidation, protein carbonylation, and oxidative stress in DNA. These findings suggest that GEN's hepatoprotective effects are attributed to its antioxidant properties.
JOURNAL OF BASIC AND APPLIED ZOOLOGY
(2023)
Article
Biology
Alaaeldin Ahmed Hamza, Soha Osama Hassanin, Salsabil Hamza, Ali Abdalla, Amr Amin
Summary: Olive leaf extracts can alleviate doxorubicin-induced cardiotoxicity and oxidative stress damage, and combination with doxorubicin enhances cytotoxicity in liver cancer cell line.
JOURNAL OF BASIC AND APPLIED ZOOLOGY
(2021)
Article
Biology
Alaaeldin Ahmed Hamza, Soha Osama Hassanin, Salsabil Hamza, Ali Abdalla, Amr Amin
Summary: Ethanol olive leaf extract can alleviate doxorubicin-induced cardiotoxicity and oxidative stress in rat cardiac tissues.
JOURNAL OF BASIC AND APPLIED ZOOLOGY
(2021)
Article
Biology
Sara Mahmmoud EL-Dakhly, Abeer Abdallah Ali Salama, Soha Osama Mahmoud Hassanin, Noha Nazeeh Yassen, Alaaeldin Ahmed Hamza, Amr Amin
BMC RESEARCH NOTES
(2020)
Article
Biology
Alaaeldin Ahmed Hamza, Mona Gamel Mohamed, Fawzy Mohamed Lashin, Amr Amin
JOURNAL OF BASIC AND APPLIED ZOOLOGY
(2020)
Meeting Abstract
Cell Biology
A. Amin, A. A. Hamza, E. M. Fikry, W. Abdallah
MOLECULAR BIOLOGY OF THE CELL
(2018)
