Functional Mutation of Multiple Solvent-Exposed Loops in the Ecballium elaterium Trypsin Inhibitor-II Cystine Knot Miniprotein

Peptide-Based Probes for Targeted Molecular Imaging

(2010) Seulki Lee et al.   BIOCHEMISTRY

A Dual-Labeled Knottin Peptide for PET and Near-Infrared Fluorescence Imaging of Integrin Expression in Living Subjects

(2010) Richard H. Kimura et al.   BIOCONJUGATE CHEMISTRY

PET Imaging of Tumor Neovascularization in a Transgenic Mouse Model with a Novel 64Cu-DOTA-Knottin Peptide

(2010) C. H. Nielsen et al.   CANCER RESEARCH

Efficient Tumor Targeting with High-Affinity Designed Ankyrin Repeat Proteins: Effects of Affinity and Molecular Size

(2010) C. Zahnd et al.   CANCER RESEARCH

Engineered cystine-knot miniproteins for diagnostic applications

(2010) Harald Kolmar   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Cystine-knot peptides engineered with specificities for αIIbβ3 or αIIbβ3 and αvβ3 integrins are potent inhibitors of platelet aggregation

(2010) Adam P. Silverman et al.   JOURNAL OF MOLECULAR RECOGNITION

Targeted Contrast-Enhanced Ultrasound Imaging of Tumor Angiogenesis with Contrast Microbubbles Conjugated to Integrin-Binding Knottin Peptides

(2010) J. K. Willmann et al.   JOURNAL OF NUCLEAR MEDICINE

Evaluation of a 64Cu-Labeled Cystine-Knot Peptide Based on Agouti-Related Protein for PET of Tumors Expressing  v 3 Integrin

(2010) L. Jiang et al.   JOURNAL OF NUCLEAR MEDICINE

Ligands for Mapping αvβ3-Integrin Expression in Vivo

(2009) Margret Schottelius et al.   ACCOUNTS OF CHEMICAL RESEARCH

An Engineered Knottin Peptide Labeled with18F for PET Imaging of Integrin Expression

(2009) Zheng Miao et al.   BIOCONJUGATE CHEMISTRY

Improving Tumor Uptake and Pharmacokinetics of64Cu-Labeled Cyclic RGD Peptide Dimers with Gly3and PEG4Linkers

(2009) Jiyun Shi et al.   BIOCONJUGATE CHEMISTRY

Radiolabeled Cyclic RGD Peptides as Integrin αvβ3-Targeted Radiotracers: Maximizing Binding Affinity via Bivalency

(2009) Shuang Liu   BIOCONJUGATE CHEMISTRY

Engineered Knottin Peptides: A New Class of Agents for Imaging Integrin Expression in Living Subjects

(2009) R. H. Kimura et al.   CANCER RESEARCH

Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins

(2009) Harald Kolmar   CURRENT OPINION IN PHARMACOLOGY

A modeling analysis of the effects of molecular size and binding affinity on tumor targeting

(2009) M. M. Schmidt et al.   MOLECULAR CANCER THERAPEUTICS

Sunflower Trypsin Inhibitor 1 Derivatives as Molecular Scaffolds for the Development of Novel Peptidic Radiopharmaceuticals

(2009) Regine García Boy et al.   MOLECULAR IMAGING AND BIOLOGY

64Cu-Labeled Affibody Molecules for Imaging of HER2 Expressing Tumors

(2009) Zhen Cheng et al.   MOLECULAR IMAGING AND BIOLOGY

Engineered cystine knot peptides that bind αvβ3, αvβ5, and α5β1 integrins with low-nanomolar affinity

(2009) Richard H. Kimura et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Interrogating and Predicting Tolerated Sequence Diversity in Protein Folds: Application to E. elaterium Trypsin Inhibitor-II Cystine-Knot Miniprotein

(2009) Jennifer L. Lahti et al.   PLoS Computational Biology

Imaging of integrin αvβ3 expression

(2008) Ambros J. Beer et al.   CANCER AND METASTASIS REVIEWS

Imaging of Integrins as Biomarkers for Tumor Angiogenesis

(2008) Weibo Cai et al.   CURRENT PHARMACEUTICAL DESIGN

Influence of valency and labelling chemistry on in vivo targeting using radioiodinated HER2-binding Affibody molecules

(2008) Vladimir Tolmachev et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Alternative binding proteins: Biological activity and therapeutic potential of cystine-knot miniproteins

(2008) Harald Kolmar   FEBS Journal

Engineered Cystine-Knot Peptides that Bind αvβ3 Integrin with Antibody-Like Affinities

(2008) Adam P. Silverman et al.   JOURNAL OF MOLECULAR BIOLOGY

Small-Animal PET Imaging of Human Epidermal Growth Factor Receptor Type 2 Expression with Site-Specific 18F-Labeled Protein Scaffold Molecules

(2008) Z. Cheng et al.   JOURNAL OF NUCLEAR MEDICINE

Knottin cyclization: impact on structure and dynamics

(2008) Annie Heitz et al.   BMC STRUCTURAL BIOLOGY