Chemical Synthesis, Backbone Cyclization and Oxidative Folding of Cystine-knot Peptides — Promising Scaffolds for Applications in Drug Design

Circular Micro-Proteins and Mechanisms of Cyclization

(2012) Brendon F. Conlan et al.   CURRENT PHARMACEUTICAL DESIGN

Natural and Engineered Cystine Knot Miniproteins for Diagnostic and Therapeutic Applications

(2012) Harald Kolmar   CURRENT PHARMACEUTICAL DESIGN

Cyclotides as a basis for drug design

(2012) David J Craik et al.   Expert Opinion on Drug Discovery

I111n-Labeled Cystine-Knot Peptides Based on the Agouti-Related Protein for Targeting Tumor Angiogenesis

(2012) Lei Jiang et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Cysteine racemization during the Fmoc solid phase peptide synthesis of the Nav1.7-selective peptide - protoxin II

(2012) Jae H. Park et al.   JOURNAL OF PEPTIDE SCIENCE

From pico to nano: biofunctionalization of cube-octameric silsesquioxanes by peptides and miniproteins

(2012) Sebastian Fabritz et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

4-Methoxybenzyloxymethyl Group, a Racemization-Resistant Protecting Group for Cysteine in Fmoc Solid Phase Peptide Synthesis

(2012) Hajime Hibino et al.   ORGANIC LETTERS

Handling a tricycle: Orthogonal versus random oxidation of the tricyclic inhibitor cystine knotted peptide gurmarin

(2012) Rasmus Eliasen et al.   PEPTIDES

Protease-Resistant Peptide Ligands from a Knottin Scaffold Library

(2011) Jennifer A. Getz et al.   ACS Chemical Biology

Optimal Oxidative Folding of the Novel Antimicrobial Cyclotide fromHedyotis bifloraRequires High Alcohol Concentrations

(2011) Clarence T. T. Wong et al.   BIOCHEMISTRY

Bioactive cystine knot proteins

(2011) Norelle L Daly et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Identification and Characterization of a New Family of Cell-penetrating Peptides

(2011) Laura Cascales et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways

(2011) Janette Contreras et al.   JOURNAL OF CONTROLLED RELEASE

The Chemistry of Cyclotides

(2011) David J Craik et al.   JOURNAL OF ORGANIC CHEMISTRY

α-Conotoxin ImI Incorporating Stable Cystathionine Bridges Maintains Full Potency and Identical Three-Dimensional Structure

(2011) Zoltan Dekan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functional Mutation of Multiple Solvent-Exposed Loops in the Ecballium elaterium Trypsin Inhibitor-II Cystine Knot Miniprotein

(2011) Richard H. Kimura et al.   PLoS One

Backbone Dynamics of Cyclotide MCoTI-I Free and Complexed with Trypsin

(2010) Shadakshara S. Puttamadappa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Interlocking Disulfides in Circular Proteins: Toward Efficient Oxidative Folding of Cyclotides

(2010) Teshome Leta Aboye et al.   ANTIOXIDANTS & REDOX SIGNALING

The Folding of Disulfide-Rich Proteins

(2010) David J. Craik   ANTIOXIDANTS & REDOX SIGNALING

Site-Specific Effects of Diselenide Bridges on the Oxidative Folding of a Cystine Knot Peptide, ω-Selenoconotoxin GVIA

(2010) Konkallu Hanumae Gowd et al.   BIOCHEMISTRY

Invited reviewnative chemical ligation applied to the synthesis and bioengineering of circular peptides and proteins

(2010) Richard J. Clark et al.   BIOPOLYMERS

An Efficient Approach for the Total Synthesis of Cyclotides by Microwave Assisted Fmoc-SPPS

(2010) Sungkyu Park et al.   International Journal of Peptide Research and Therapeutics

The cyclotide cycloviolacin O2 from Viola odorata has potent bactericidal activity against Gram-negative bacteria

(2010) M. Pranting et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Cystine-knot peptides engineered with specificities for αIIbβ3 or αIIbβ3 and αvβ3 integrins are potent inhibitors of platelet aggregation

(2010) Adam P. Silverman et al.   JOURNAL OF MOLECULAR RECOGNITION

Optimization of oxidative folding methods for cysteine-rich peptides: a study of conotoxins containing three disulfide bridges

(2010) Andrew M. Steiner et al.   JOURNAL OF PEPTIDE SCIENCE

Diselenium, instead of disulfide, bonded analogs of conotoxins: novel synthesis and pharmacotherapeutic potential

(2010) Robert B. Raffa   LIFE SCIENCES

Solid-Phase Synthesis of the Lipopeptide Myr-HBVpreS/2-78, a Hepatitis B Virus Entry Inhibitor

(2010) Alexa Schieck et al.   MOLECULES

Synthesis, biophysical, and biological studies of wild-type and mutant psalmopeotoxins—Anti-malarial cysteine knot peptides from Psalmopoeus cambridgei

(2010) Pacharin Kamolkijkarn et al.   PEPTIDES

Characterization and 2D NMR study of the stable [9-21, 15-27] 2 disulfide intermediate in the folding of the 3 disulfide trypsin inhibitor EETI II

(2010) D. Le-Nguyen et al.   PROTEIN SCIENCE

Efficient Solid-Phase Synthesis of Sulfotyrosine Peptides using a Sulfate Protecting-Group Strategy

(2009) Ahmed M. Ali et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biosynthesis and Biological Screening of a Genetically Encoded Library Based on the Cyclotide MCoTI-I

(2009) Jeffrey Austin et al.   CHEMBIOCHEM

Amino Acid-Protecting Groups

(2009) Albert Isidro-Llobet et al.   CHEMICAL REVIEWS

Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins

(2009) Harald Kolmar   CURRENT OPINION IN PHARMACOLOGY

Internal Cysteine Accelerates Thioester-Based Peptide Ligation

(2009) Christian Haase et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Combined X-ray and NMR Analysis of the Stability of the Cyclotide Cystine Knot Fold That Underpins Its Insecticidal Activity and Potential Use as a Drug Scaffold

(2009) Conan K. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineered Cystine Knot Miniproteins as Potent Inhibitors of Human Mast Cell Tryptase β

(2009) Christian P. Sommerhoff et al.   JOURNAL OF MOLECULAR BIOLOGY

Dissecting the Oxidative Folding of Circular Cystine Knot Miniproteins

(2008) Sunithi Gunasekera et al.   ANTIOXIDANTS & REDOX SIGNALING

Engineering Stabilized Vascular Endothelial Growth Factor-A Antagonists: Synthesis, Structural Characterization, and Bioactivity of Grafted Analogues of Cyclotides

(2008) Sunithi Gunasekera et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combinatorial Optimization of a CD4-Mimetic Miniprotein and Cocrystal Structures with HIV-1 gp120 Envelope Glycoprotein

(2008) François Stricher et al.   JOURNAL OF MOLECULAR BIOLOGY

Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides

(2008) Panumart Thongyoo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Structure of a Two-Disulfide Intermediate Assists in Elucidating the Oxidative Folding Pathway of a Cyclic Cystine Knot Protein

(2008) Maša Cemazar et al.   STRUCTURE

Knottin cyclization: impact on structure and dynamics

(2008) Annie Heitz et al.   BMC STRUCTURAL BIOLOGY

Oxidative Folding of Cyclic Cystine Knot Proteins

(2007) Maša Čemažar et al.   ANTIOXIDANTS & REDOX SIGNALING

Ultra-Stable Peptide Scaffolds for Protein Engineering—Synthesis and Folding of the Circular Cystine Knotted Cyclotide Cycloviolacin O2

(2007) Teshome Leta Aboye et al.   CHEMBIOCHEM

Head-to-Tail Cyclized Cystine-Knot Peptides by a Combined Recombinant and Chemical Route of Synthesis

(2007) Olga Avrutina et al.   CHEMBIOCHEM