Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability

(2013) Eyleen J. O’Rourke et al.   NATURE CELL BIOLOGY

Characterization of the Lipid Droplet Proteome of a Clonal Insulin-producing β-Cell Line (INS-1 832/13)

(2012) Sara Larsson et al.   JOURNAL OF PROTEOME RESEARCH

Rapamycin Causes Upregulation of Autophagy and Impairs Islets Function Both In Vitro and In Vivo

(2011) M. Tanemura et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Plasma Lipidomic Analysis of Stable and Unstable Coronary Artery Disease

(2011) Peter J. Meikle et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking

(2011) Ebru Boslem et al.   BIOCHEMICAL JOURNAL

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

(2011) Mireille Ouimet et al.   Cell Metabolism

Coordination of Triacylglycerol and Cholesterol Homeostasis by DHR96 and the Drosophila LipA Homolog magro

(2011) Matthew H. Sieber et al.   Cell Metabolism

Early steps in steroidogenesis: intracellular cholesterol trafficking

(2011) Walter L. Miller et al.   JOURNAL OF LIPID RESEARCH

Glycerolipid/free fatty acid cycle and islet β-cell function in health, obesity and diabetes

(2011) Marc Prentki et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Thiadiazole Carbamates: Potent Inhibitors of Lysosomal Acid Lipase and Potential Niemann−Pick Type C Disease Therapeutics

(2010) Anton I. Rosenbaum et al.   JOURNAL OF MEDICINAL CHEMISTRY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Targeting triglyceride/fatty acid cycling in β-cells as a therapy for augmenting glucose-stimulated insulin secretion

(2010) James Cantley et al.   Islets

Potential role of autophagy in modulation of lipid metabolism

(2009) Julia Kovsan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Chemical screen to reduce sterol accumulation in Niemann–Pick C disease cells identifies novel lysosomal acid lipase inhibitors

(2009) Anton I. Rosenbaum et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Deletion of PKC  Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse  -Cells

(2009) J. Cantley et al.   DIABETES

Adipose Triglyceride Lipase Is Implicated in Fuel- and Non-fuel-stimulated Insulin Secretion

(2009) Marie-Line Peyot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological and coordinate downregulation of the NPC1 and NPC2 genes are associated with the sequestration of LDL-derived cholesterol within endocytic compartments

(2009) David Jelinek et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Metabolic cycling in control of glucose-stimulated insulin secretion

(2008) Mette V. Jensen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lipases in the pancreatic β-cell: implications for insulin secretion

(2008) Malin Fex et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Protein Kinase C Function in Muscle, Liver, and  -Cells and Its Therapeutic Implications for Type 2 Diabetes

(2008) C. Schmitz-Peiffer et al.   DIABETES

A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis

(2008) M. Fex et al.   DIABETOLOGIA

The islet β-cell: fuel responsive and vulnerable

(2008) Christopher J. Nolan et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM