Review
Pharmacology & Pharmacy
Yaoxiang Tang, Ying Zhou, Songqing Fan, Qiuyuan Wen
Summary: This review article summarizes the importance of HSP60 in cancer, including its structure, functional cycle, regulatory mechanism, and its applications in diagnosis and therapy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Federica Scalia, Alessandra Maria Vitale, Radha Santonocito, Everly Conway de Macario, Alberto J. L. Macario, Francesco Cappello
Summary: The chaperone system plays a critical role in maintaining protein quality control, with dysfunctions leading to chaperonopathies that impact various tissues and organs throughout the body. Neurochaperonopathies are divided into genetic and acquired forms, associated with different abnormal molecular chaperones. Awareness of the impact of chaperonopathies on diseases can improve diagnosis and treatment options.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Laura Perna, Matteo Castelli, Elena Frasnetti, Lisa E. L. Romano, Giorgio Colombo, Chrisostomos Prodromou, J. Paul Chapple
Summary: In this study, an AlphaFold structure of sacsin was compared with yeast Hsp90, revealing novel insights into the structure of sacsin. Residues within sacsin's Hsp90-like domains required for ATP binding and hydrolysis were identified, including catalytic arginine residues equivalent to Hsp90's middle domain. This study supports the hypothesis that sacsin functions as an ATP-driven super molecular chaperone.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Medicine, General & Internal
Jack J. Collier, Claire Guissart, Monika Olahova, Souphatta Sasorith, Florence Piron-Prunier, Fumi Suomi, David Zhang, Nuria Martinez-Lopez, Nicolas Leboucq, Angela Bahr, Silvia Azzarello-Burri, Selina Reich, Ludger Schoels, Tuomo M. Polvikoski, Pierre Meyer, Lise Larrieu, Andrew M. Schaefer, Hessa S. Alsaif, Suad Alyamani, Stephan Zuchner, Ines A. Barbosa, Charu Deshpande, Angela Pyle, Anita Rauch, Matthis Synofzik, Fowzan S. Alkuraya, Francois Rivier, Mina Ryten, Robert McFarland, Agnes Delahodde, Thomas G. McWilliams, Michel Koenig, Robert W. Taylor
Summary: This study identified several patients with neurodevelopmental disorders who survived with severe loss or complete absence of ATG7, an essential effector enzyme for autophagy without a known functional paralogue.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Siddhi Chitre, Anne-Marie Ray, Mckayla Stevens, Emma H. Doud, Hope Liechty, Alex Washburn, Katelyn Tepper, Jared Sivinski, Heather M. O'Hagan, Millie M. Georgiadis, Eli Chapman, Steven M. Johnson
Summary: Protein homeostasis in tumor progression has been proven to be important, but little is known about the therapeutic potential of targeting the HSP60 chaperonin system. This study suggests that targeting aberrant HSP60 in the cytosol could be a promising chemotherapeutic strategy for cancer treatment.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Aitor Franco, Pablo Gracia, Adai Colom, Jose D. Camino, Jose Angel Fernandez-Higuero, Natalia Orozco, Alexander Dulebo, Leonor Saiz, Nunilo Cremades, Jose M. G. Vilar, Adelina Prado, Arturo Muga
Summary: Research shows that the Hsc70-based disaggregase system preferentially breaks down toxic oligomers and short fibrils, while its activity against larger, less toxic amyloids is severely impaired. This behavior is the result of an all-or-none abrupt solubilization of individual aggregates.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Ana Rodriguez-Ramos, Jesus A. Gonzalez, Monica L. Fanarraga
Summary: As the population ages, the looming epidemic of neurodegenerative diseases with devastating social consequences is driving the need for novel therapeutic strategies. Nanotechnology, especially in the design of nanoscale systems, is crucial in developing methods to identify and treat neural protein-folding disorders. Recent advancements include the design of a highly versatile nanorobot with a protein coating that enables folding and restoration of heat-denatured proteins, which shows effective inhibition of amyloid formation. Intelligent biocompatible coatings present exceptional prospects for the development of advanced nanodevices in biomedicine and biotechnology.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Junna Hayashi, John A. Carver
Summary: This article reviews the current literature on human βS to better understand its role in homeostasis and pathology. The structure of βS is discussed, as well as its ability to act as a molecular chaperone, regulate synaptic function and other cellular pathways. The mutations associated with dementia with Lewy bodies are also explored, along with the impact of post-translational modifications on βS.
Article
Microbiology
Jared Sivinski, Andrew J. Ambrose, Iliya Panfilenko, Christopher J. Zerio, Jason M. Machulis, Niloufar Mollasalehi, Lynn K. Kaneko, Mckayla Stevens, Anne-Marie Ray, Yangshin Park, Chunxiang Wu, Quyen Q. Hoang, Steven M. Johnson, Eli Chapman
Summary: The GroES/GroEL chaperonin system in bacteria is essential and potentially a target for antibiotics. However, the functional differences between GroES/GroEL chaperonins from different bacteria, including ESKAPE pathogens, suggest potential challenges in developing chaperonin-targeted antibiotics.
Review
Cell Biology
Aitor Franco, Lorea Velasco-Carneros, Naiara Alvarez, Natalia Orozco, Fernando Moro, Adelina Prado, Arturo Muga
Summary: Neurodegenerative diseases are increasingly recognized as leading causes of global deaths, especially with the aging population. Recent studies have shown that the chaperone system can disassemble protein aggregates associated with neurodegenerative diseases, potentially significant for the development of new therapies.
Article
Neurosciences
Antonella Marino Gammazza, Vincenzo Restivo, Roberta Baschi, Celeste Caruso Bavisotto, Angelo B. Cefalu, Giulia Accardi, Everly Conway de Macario, Alberto J. L. Macario, Francesco Cappello, Roberto Monastero
Summary: Molecular chaperones play key roles in neurodegenerative diseases, with higher levels of Hsp60 and Hsp70 found in AD patients, while lower levels of Hsp90 were observed in both aMCI and AD. However, these findings lost significance after adjustment for multiple comparisons, indicating the need for further studies with larger populations.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Giusi Alberti, Giuseppe Vergilio, Letizia Paladino, Rosario Barone, Francesco Cappello, Everly Conway de Macario, Alberto J. L. Macario, Fabio Bucchieri, Francesca Rappa
Summary: Breast cancer is a major public health problem, and the role of the chaperone system in its development and treatment is still poorly understood. This article discusses the pro-carcinogenic roles of four chaperones, Hsp27, Hsp60, Hsp70, and Hsp90, in breast cancer and their potential for anti-cancer therapies. The article also briefly explores the potential of extracellular vesicles in breast cancer diagnosis and management. Overall, understanding the chaperone system can provide new insights into the mechanisms of breast cancer and the development of targeted treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Anne-Marie Ray, Nilshad Salim, Mckayla Stevens, Siddhi Chitre, Sanofar Abdeen, Alex Washburn, Jared Sivinski, Heather M. O'Hagan, Eli Chapman, Steven M. Johnson
Summary: This study investigated the selective cytotoxicity of inhibitors targeting HSP60 on colorectal cancer cells, identifying 24 inhibitors with superior properties. The results suggest the potential of HSP60 as a viable chemotherapeutic target for colorectal cancer.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Yun Liu, Ji Miao
Summary: This paper summarizes the effects of defective copper homeostasis on heart disease and discusses potential underlying molecular mechanisms.
Article
Chemistry, Medicinal
Hao Shao, Xiaokai Li, Shigenari Hayashi, Jeanette L. Bertron, Daniel M. C. Schwarz, Benjamin C. Tang, Jason E. Gestwicki
Summary: The research team synthesized 17 derivatives of YM-08, among which compound JG-23 showed 12-fold better metabolic stability and retained the ability to reduce tau levels in cell models. These chemical probes are expected to be useful tools for studying tau homeostasis.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
