β-Synuclein: An Enigmatic Protein with Diverse Functionality

The Effect of Oxidized Dopamine on the Structure and Molecular Chaperone Function of the Small Heat-Shock Proteins, αB-Crystallin and Hsp27

(2021) Junna Hayashi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

β-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins

(2021) Natalia Ninkina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The multifaceted nature of αB-crystallin

(2020) Junna Hayashi et al.   CELL STRESS & CHAPERONES

A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function

(2020) Ciaran P. A. Doherty et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration

(2019) Dmitri Lodygin et al.   NATURE

The Autophagy Lysosomal Pathway and Neurodegeneration

(2019) Steven Finkbeiner   Cold Spring Harbor Perspectives in Biology

Intrinsically disordered proteins and structured proteins with intrinsically disordered regions have different functional roles in the cell

(2019) Antonio Deiana et al.   PLoS One

Comparative Analysis of the Conformation, Aggregation, Interaction, and Fibril Morphologies of Human α-, β-, and γ-Synuclein Proteins

(2018) Manish Kumar Jain et al.   BIOCHEMISTRY

Accumulation of beta-synuclein in cortical neurons is associated with autophagy attenuation in the brains of dementia with Lewy body patients

(2018) Tracey Evans et al.   BRAIN RESEARCH

Age-related Beta-synuclein Alters the p53/Mdm2 Pathway and Induces the Apoptosis of Brain Microvascular Endothelial Cells In Vitro

(2018) Katrin Brockhaus et al.   CELL TRANSPLANTATION

Levels of α- and β-synuclein regulate cellular susceptibility to toxicity from α-synuclein oligomers

(2018) Dafina M. Angelova et al.   FASEB JOURNAL

Unveiling a Selective Mechanism for the Inhibition of α-Synuclein Aggregation by β-Synuclein

(2018) Andre Leitao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways

(2018) Elena Sánchez et al.   MOLECULAR NEUROBIOLOGY

Immature-like molecular expression patterns in the hippocampus of a mouse model of dementia with Lewy body-linked mutant β-synuclein

(2018) Hideo Hagihara et al.   Molecular Brain

Significant Changes in Plasma Alpha-Synuclein and Beta-Synuclein Levels in Male Children with Autism Spectrum Disorder

(2018) Wilaiwan Sriwimol et al.   Biomed Research International

Sumoylation Protects Against β-Synuclein Toxicity in Yeast

(2018) Blagovesta Popova et al.   Frontiers in Molecular Neuroscience

Vibrational circular dichroism sheds new light on the competitive effects of crowding and β-synuclein on the fibrillation process of α-synuclein

(2018) Evelien Van de Vondel et al.   BIOCHEMISTRY

γ-Synuclein Is an Adipocyte-Neuron Gene Coordinately Expressed with Leptin and Increased in Human Obesity

(2018) Pieter J. Oort et al.   JOURNAL OF NUTRITION

A pH-dependent switch promotes β-synuclein fibril formation via glutamate residues

(2017) Gina M. Moriarty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays

(2017) Sovanarak Lek et al.   Jove-Journal of Visualized Experiments

Finding Our Way in the Dark Proteome

(2016) Asmit Bhowmick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alpha-, Beta-, and Gamma-synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer′s and Creutzfeldt-Jakob Disease but No Alteration in Synucleinopathies

(2016) Patrick Oeckl et al.   MOLECULAR & CELLULAR PROTEOMICS

Combinational losses of synucleins reveal their differential requirements for compensating age-dependent alterations in motor behavior and dopamine metabolism

(2016) Natalie Connor-Robson et al.   NEUROBIOLOGY OF AGING

β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces

(2016) James W. P. Brown et al.   Scientific Reports

Functional advantages of dynamic protein disorder

(2015) Rebecca B. Berlow et al.   FEBS LETTERS

Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity

(2015) Sandra Tenreiro et al.   HUMAN MOLECULAR GENETICS

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The loss of inhibitory C-terminal conformations in disease associated P123H β-synuclein

(2015) Maria K. Janowska et al.   PROTEIN SCIENCE

Unveiling transient protein-protein interactions that modulate inhibition of alpha-synuclein aggregation by beta-synuclein, a pre-synaptic protein that co-localizes with alpha-synuclein

(2015) Maria K. Janowska et al.   Scientific Reports

Small heat-shock proteins: important players in regulating cellular proteostasis

(2014) Teresa M. Treweek et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Differences in the Binding of Copper(I) to α- and β-Synuclein

(2014) Riccardo De Ricco et al.   INORGANIC CHEMISTRY

Proteome-wide analysis of human disease mutations in short linear motifs: neglected players in cancer?

(2014) Bora Uyar et al.   Molecular BioSystems

Directed evolution of APEX2 for electron microscopy and proximity labeling

(2014) Stephanie S Lam et al.   NATURE METHODS

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons

(2013) Grit Taschenberger et al.   ANNALS OF NEUROLOGY

In VivoCross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells

(2013) Ulf Dettmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Ageing of Alpha- and Beta-Synucleins: Protein Damage and Repair Mechanisms

(2013) Vasanthy Vigneswara et al.   PLoS One

Monomeric Synucleins Generate Membrane Curvature

(2012) Christopher H. Westphal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantifying Interactions of β-Synuclein and γ-Synuclein with Model Membranes

(2012) Vanessa C. Ducas et al.   JOURNAL OF MOLECULAR BIOLOGY

Alzheimer disease periventricular white matter lesions exhibit specific proteomic profile alterations

(2012) Eduardo M. Castao et al.   NEUROCHEMISTRY INTERNATIONAL

Defining the Substrate Specificity Determinants Recognized by the Active Site of C-Terminal Src Kinase-Homologous Kinase (CHK) and Identification of β-Synuclein as a Potential CHK Physiological Substrate

(2011) Kim K. Ia et al.   BIOCHEMISTRY

Transcriptional Regulation of the Beta-Synuclein 5′-Promoter Metal Response Element by Metal Transcription Factor-1

(2011) Patrick C. McHugh et al.   PLoS One

Correction: Alpha-Synuclein Is a Cellular Ferrireductase

(2011) Paul Davies et al.   PLoS One

Association of α-, β-, and γ-Synuclein With Diffuse Lewy Body Disease

(2010) Kenya Nishioka et al.   ARCHIVES OF NEUROLOGY

Alpha- and Beta-Synucleins mRNA Expression in Lymphocytes of Schizophrenia Patients

(2010) Mohammad Reza Noori-Daloii et al.   Genetic Testing and Molecular Biomarkers

Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins

(2010) Jobin Varkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibiting α-Synuclein Oligomerization by Stable Cell-Penetrating β-Synuclein Fragments Recovers Phenotype of Parkinson's Disease Model Flies

(2010) Ronit Shaltiel-Karyo et al.   PLoS One

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

A β-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain

(2010) Masayo Fujita et al.   Nature Communications

Unique copper-induced oligomers mediate alpha-synuclein toxicity

(2009) Josephine A. Wright et al.   FASEB JOURNAL

Phosphorylation of Synucleins by Members of the Polo-like Kinase Family

(2009) Martial K. Mbefo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoimmune spread to myelin is associated with experimental autoimmune encephalomyelitis induced by a neuronal protein, β-Synuclein

(2009) Neta Kela-Madar et al.   JOURNAL OF NEUROIMMUNOLOGY

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

β-Synuclein occursin vivoin lipid-associated oligomers and forms hetero-oligomers with α-synuclein

(2008) Eitan Israeli et al.   JOURNAL OF NEUROCHEMISTRY

Site-Specific Interactions of Cu(II) with α and β-Synuclein: Bridging the Molecular Gap between Metal Binding and Aggregation

(2008) Andrés Binolfi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular determinants of the aggregation behavior of α- and β-synuclein

(2008) Robert C. Rivers et al.   PROTEIN SCIENCE

Cytosolic O-glycosylation is abundant in nerve terminals

(2003) Robert N. Cole et al.   JOURNAL OF NEUROCHEMISTRY