Inhibitors of CXC chemokine receptor type 4

Crosstalk between CXCR4/Stromal Derived Factor-1 and VLA-4/VCAM-1 Pathways Regulates Neutrophil Retention in the Bone Marrow

(2014) J. M. Petty et al.   JOURNAL OF IMMUNOLOGY

Short-term intermittent administration of CXCR4 antagonist AMD3100 facilitates myocardial repair in experimental myocardial infarction

(2013) Yuechen Luo et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Integrin Regulation during Leukocyte Recruitment

(2013) J. Herter et al.   JOURNAL OF IMMUNOLOGY

PKB/Akt-Dependent Regulation of Cell Motility

(2013) G. Xue et al.   JNCI-Journal of the National Cancer Institute

The SDF-1/CXCR4 axis in stem cell preconditioning

(2012) C. Cencioni et al.   CARDIOVASCULAR RESEARCH

CXC-Chemokine Receptor 4 Antagonist AMD3100 Promotes Cardiac Functional Recovery After Ischemia/Reperfusion Injury via Endothelial Nitric Oxide Synthase–Dependent Mechanism

(2012) Kentaro Jujo et al.   CIRCULATION

BMS-936564/MDX-1338: A Fully Human Anti-CXCR4 Antibody Induces Apoptosis In Vitro and Shows Antitumor Activity In Vivo in Hematologic Malignancies

(2012) M. R. Kuhne et al.   CLINICAL CANCER RESEARCH

Long-term administration of AMD3100, an antagonist of SDF-1/CXCR4 signaling, alters fracture repair

(2012) Chrisoula A. Toupadakis et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Differential Targeting of the E-Cadherin/β-Catenin Complex by Gram-Positive Probiotic Lactobacilli Improves Epithelial Barrier Function

(2011) Stephanie Hummel et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome

(2011) D. H. McDermott et al.   BLOOD

Drug Discovery Research Targeting the CXC Chemokine Receptor 4 (CXCR4)

(2011) Won-Tak Choi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

CXCR4 Antagonist AMD3100 Modulates Claudin Expression and Intestinal Barrier Function in Experimental Colitis

(2011) Xian-Ming Xia et al.   PLoS One

Fibrocytes in chronic lung disease – Facts and controversies

(2011) Shyam S. Maharaj et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The bone marrow microenvironment and leukemia: biology and therapeutic targeting

(2011) Edward Allan R Sison et al.   Expert Review of Hematology

Agonists for the Chemokine Receptor CXCR4

(2011) Marilou Lefrançois et al.   ACS Medicinal Chemistry Letters

E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin  L 2-mediated slow leukocyte rolling

(2010) T. Yago et al.   BLOOD

Inhibitory effect of CXC chemokine receptor 4 antagonist AMD3100 on bleomycin induced murine pulmonary fibrosis

(2010) Jeong Sup Song et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Role of the SDF-1-CXCR4 axis in stem cell-based therapies for ischemic cardiomyopathy

(2010) Marc-Michael Zaruba et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Recent advances on the use of the CXCR4 antagonist plerixafor (AMD3100, Mozobil™) and potential of other CXCR4 antagonists as stem cell mobilizers

(2010) Erik De Clercq   PHARMACOLOGY & THERAPEUTICS

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Neutrophil kinetics in health and disease

(2010) Charlotte Summers et al.   TRENDS IN IMMUNOLOGY

CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis

(2010) Soo-Hyun Chung et al.   ARTHRITIS RESEARCH & THERAPY

CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions

(2009) Kyle J. Eash et al.   BLOOD

CXCL12 Is a constitutive and inflammatory chemokine in the intestinal immune system

(2009) Iris Dotan et al.   INFLAMMATORY BOWEL DISEASES

Matrix metalloproteinase and G protein coupled receptors: Co-conspirators in the pathogenesis of autoimmune disease and cancer

(2009) Sarah M. Eck et al.   JOURNAL OF AUTOIMMUNITY

Phase III Prospective Randomized Double-Blind Placebo-Controlled Trial of Plerixafor Plus Granulocyte Colony-Stimulating Factor Compared With Placebo Plus Granulocyte Colony-Stimulating Factor for Autologous Stem-Cell Mobilization and Transplantation for Patients With Non-Hodgkin's Lymphoma

(2009) John F. DiPersio et al.   JOURNAL OF CLINICAL ONCOLOGY

Hematopoietic cytokines

(2008) D. Metcalf   BLOOD

Migration across the sinusoidal endothelium regulates neutrophil mobilization in response to ELR + CXC chemokines

(2008) Peter C. E. Burdon et al.   BRITISH JOURNAL OF HAEMATOLOGY

WHIM syndrome: congenital immune deficiency disease

(2008) Toshinao Kawai et al.   CURRENT OPINION IN HEMATOLOGY

Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis

(2008) Annika Andersson-Sjöland et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Blockade of CXCL12/CXCR4 Axis Ameliorates Murine Experimental Colitis

(2008) S. Mikami et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Neutrophil Adhesion and Activation under Flow

(2008) Alexander Zarbock et al.   MICROCIRCULATION