Article
Multidisciplinary Sciences
Oh Sung Kwon, Rahul Mishra, Adham Safieddine, Emeline Coleno, Quentin Alasseur, Marion Faucourt, Isabelle Barbosa, Edouard Bertrand, Nathalie Spassky, Herve Le Hir
Summary: Exon junction complexes (EJCs) mark untranslated spliced mRNAs and play a crucial role in mRNA lifecycle. This study demonstrates the accumulation of EJCs at basal bodies of mNSC or RPE1 cells, affecting cell differentiation and growth. The down-regulation of EJCs impairs centriolar material organization and ciliogenesis, suggesting that EJC-dependent mRNA trafficking towards centrosomes and basal bodies is important for proper mNSC division and brain development.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Zachary A. Kemmerer, Kyle P. Robinson, Jonathan M. Schmitz, Mateusz Manicki, Brett R. Paulson, Adam Jochem, Paul D. Hutchins, Joshua J. Coon, David J. Pagliarini
Summary: The authors have identified two proteins, Ypl109c (Cqd1) and Ylr253w (Cqd2), with reciprocal CoQ trafficking functions in yeast, shedding light on the regulation of Coenzyme Q distribution in the cell. Loss of Cqd1 skews CoQ distribution away from mitochondria, while loss of Cqd2 promotes the opposite effect.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Jian Xu, Stephane Richard
Summary: Arginine methylation is a crucial post-translational modification that influences protein function and has significant implications for cancer therapy. Protein arginine methyltransferases (PRMTs) have been implicated in various cellular processes and are being explored as potential drug targets for cancer treatment, with some inhibitors already in clinical trials.
Article
Biochemistry & Molecular Biology
Shuyan Liu, Taishu Wang, Yulin Shi, Lu Bai, Shanshan Wang, Dong Guo, Yang Zhang, Yangfan Qi, Chaoqun Chen, Jinrui Zhang, Yingqiu Zhang, Quentin Liu, Qingkai Yang, Yang Wang, Han Liu
Summary: Liquid-liquid phase separation is a generic approach to studying the dynamic regulation of phase-separated assemblies and the roles of protein posttranslational modifications. USP42, a deubiquitylase, has been identified to play a pivotal role in nuclear speckle phase separation, mRNA splicing, and cancer cell growth. Inhibition of USP42 presents a novel anticancer strategy by targeting phase separation.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Genetics & Heredity
Minwen Jie, Tong Feng, Wei Huang, Moran Zhang, Yuliang Feng, Hao Jiang, Zhili Wen
Summary: miRNAs are believed to play a role as post-transcriptional regulators in the cytoplasm, affecting transcription and cellular homeostasis through their subcellular localization. Recent studies have revealed novel insights into the unconventional functions and mechanisms of miRNAs at the transcriptional and post-transcriptional levels.
Review
Pharmacology & Pharmacy
Doorsa Tarazi, Jason T. Maynes
Summary: Opioid utilization for pain management is common among cancer patients. However, the specific impact of opioids on cancer development remains inadequately investigated. Existing literature suggests that opioids can affect cancer cell metabolism by influencing energy production pathways and modulating redox balance. However, most studies have focused on healthy tissue and neuronal cells, limiting our understanding of the effects of opioids on different types of cancer cell metabolism.
Article
Cell Biology
Moritz Weglage, Emil Warnberg, Iakovos Lazaridis, Daniela Calvigioni, Ourania Tzortzi, Konstantinos Meletis
Summary: The study found that the three major output pathways in the dorsomedial striatum share a similarly complete representation of the entire action space, including task- and phase-specific signals of action value and choice.
Review
Oncology
Lei Wang, Zeng Jin, Rohan P. Master, Chandra K. Maharjan, Madison E. Carelock, Tiffany B. A. Reccoppa, Myung-Chul Kim, Ryan Kolb, Weizhou Zhang
Summary: This article summarizes the important features of breast cancer stem cells, major signaling pathways, and cellular interactions within the tumor microenvironment, highlighting the significance of BCSCs in breast cancer and potential therapeutic strategies.
Article
Biodiversity Conservation
Ryan A. McManamay, Chris R. Vernon, Henriette I. Jager
Summary: The study examines the potential impacts of alternative future global electrification pathways on biodiversity under different societal development scenarios. It finds that renewable energy deployment may come at high cost to ecosystems, with biodiversity conflicts more influenced by local land conservation practices and energy diversification strategies than global socioeconomic drivers.
BIOLOGICAL CONSERVATION
(2021)
Review
Chemistry, Multidisciplinary
Pei Huang, Hongzhang Deng, Changrong Wang, Yongfeng Zhou, Xiaoyuan Chen
Summary: Messenger RNA (mRNA)-based therapy is a powerful, safe, and rapidly scalable therapeutic approach. In this review, therapeutic applications of mRNA are introduced, common types of mRNA cargos and delivery systems are summarized, and strategies to enhance nanotechnology-mediated mRNA delivery efficiency during the cellular trafficking process are highlighted.
ADVANCED MATERIALS
(2023)
Article
Multidisciplinary Sciences
Hanae Sato, Robert H. Singer
Summary: The author developed a single-cell reporter system to investigate cell-to-cell variability of NMD efficiency. The study revealed a wide range of NMD efficiency in different cells, potentially linked to the expression levels of surveillance factors.
NATURE COMMUNICATIONS
(2021)
Article
Meteorology & Atmospheric Sciences
Lisa Bengtsson, Juliana Dias, Stefan Tulich, Maria Gehne, Jian-Wen Bao
Summary: In this study, the impact of using cellular automata in atmospheric convection models for subgrid organization parameterization is explored. Results indicate that with the cellular automata scheme, precipitation becomes more organized spatially and temporally, and there is a noticeable shift in equatorial wave phase speed.
JOURNAL OF ADVANCES IN MODELING EARTH SYSTEMS
(2021)
Article
Biochemistry & Molecular Biology
Runzhe Yang, Ashwin Vishwanathan, Jingpeng Wu, Nico Kemnitz, Dodam Ih, Nicholas Turner, Kisuk Lee, Ignacio Tartavull, William M. Silversmith, Chris S. Jordan, Celia David, Doug Bland, Amy Sterling, Mark S. Goldman, Emre R. F. Aksay, H. Sebastian Seung
Summary: Neuronal wiring diagrams reconstructed by electron microscopy raise new questions about the organization of nervous systems. The C. elegans connectome is a feedforward sensorimotor circuit, while a larval zebrafish brainstem wiring diagram shows overrepresentation of a 3-cell motif. The cyclic structure in the zebrafish wiring diagram could be relevant for theories of oculomotor function and temporal integration.
Article
Oncology
Caleb A. Dawson, Jane E. Visvader
Summary: This review summarizes the current understanding of mammary gland cellular organization revealed by microscopy, focusing on the mouse mammary gland and covering a broad range of immune and stromal cell types at major developmental stages, providing insights into important tissue niches and cellular interactions.
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
(2021)
Article
Multidisciplinary Sciences
Leti Nunez, Adina R. Buxbaum, Zachary B. Katz, Melissa Lopez-Jones, Chiso Nwokafor, Kevin Czaplinski, Feng Pan, Jason Rosenberg, Hannah R. Monday, Robert H. Singer
Summary: Gene expression is regulated by RNA-binding proteins, which play important roles in cell survival, differentiation, and migration. This study reveals a decrease in cortical marginal cell density and migratory cell population in knockout mice. It also investigates the regulation of /3-actin mRNA and finds increased transcription rates and protein content in neurons lacking IGF2BP1 protein, as well as impaired transport and anchoring.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Lilia Magomedova, Jens Tiefenbach, Emma Zilberman, Florian Le Billan, Veronique Voisin, Michael Saikali, Vincent Boivin, Melanie Robitaille, Serge Gueroussov, Manuel Irimia, Debashish Ray, Rucha Patel, ChangJiang Xu, Pancharatnam Jeyasuria, Gary D. Bader, Timothy R. Hughes, Quaid D. Morris, Michelle S. Scott, Henry Krause, Stephane Angers, Benjamin J. Blencowe, Carolyn L. Cummins
NUCLEIC ACIDS RESEARCH
(2019)
Article
Microbiology
Robert J. Evans, Katherine Pline, Catherine A. Loynes, Sarah Needs, Maceler Aldrovandi, Jens Tiefenbach, Ewa Bielska, Rachel E. Rubino, Christopher J. Nicol, Robin C. May, Henry M. Krause, Valerie B. O'Donnell, Stephen A. Renshaw, Simon A. Johnston
Article
Cell Biology
Arkadiy Reunov, Konstantin Yakovlev, Jack Hu, Yulia Reunova, Alina Komkova, Yana Alexandrova, Evgenia Pimenova, Jens Tiefenbach, Henry Krause
Article
Genetics & Heredity
Minhee Kim, Olivia Y. Du, Rachael J. Whitney, Ronit Wilk, Jack Hu, Henry M. Krause, Joshua Kavaler, Bruce H. Reed
G3-GENES GENOMES GENETICS
(2020)
Review
Genetics & Heredity
Hyunmin Lee, Zhaolei Zhang, Henry M. Krause
TRENDS IN GENETICS
(2019)
Article
Developmental Biology
Jason Burgess, Jeffrey T. Burrows, Roshan Sadhak, Sharon Chiang, Alex Weiss, Cassandra D'Amata, Alyssa M. Molinaro, Shujun Zhu, Michael Long, Chun Hu, Henry M. Krause, Bret J. Pearson
DEVELOPMENTAL BIOLOGY
(2020)
Article
Environmental Sciences
Jiajun Han, Wen Gu, Holly Barrett, Diwen Yang, Song Tang, Jianxian Sun, Jiabao Liu, Henry M. Krause, Keith A. Houck, Hui Peng
Summary: The study identified five structural categories of PFAS prone to metabolism, with hydrolysis identified as a major metabolism pathway for diverse PFAS highly related to their structures.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Genetics & Heredity
Evan Witt, Zhantao Shao, Chun Hu, Henry M. Krause, Li Zhao
Summary: This study explored dosage compensation in Drosophila testis at the single-cell level, revealing that certain germ cell types exhibit X chromosome expression similar to autosomes, indicating dosage compensation activity. Genes near chromatin entry sites showed higher expression in cell types with dosage compensation, providing additional evidence of this process. Lack of expression of most dosage compensation complex genes suggests a potential noncanonical mechanism mediating observed pre-meiotic dosage compensation. These findings offer new insights into the understanding of sex chromosomes.
Article
Chemistry, Medicinal
Cigdem Sahin, Lilia Magomedova, Thais A. M. Ferreira, Jiabao Liu, Jens Tiefenbach, Priscilla S. Alves, Fellipe J. G. Queiroz, Andressa S. de Oliveira, Mousumi Bhattacharyya, Julie Grouleff, Patricia C. N. Nogueira, Edilberto R. Silveira, Daniel C. Moreira, Jose Roberto Souza de Almeida Leite, Guilherme D. Brand, David Uehling, Gennady Poda, Henry Krause, Carolyn L. Cummins, Luiz A. S. Romeiro
Summary: Metabolic diseases are increasing at alarming rates globally. This study explored the potential use of phenolic lipid derivatives from cashew nut shell liquid as drugs for the treatment of diabetes and obesity. The compounds showed PPAR activity and tissue-specific effects, making them promising candidates for further development.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jiabao Liu, Cigdem Sahin, Samar Ahmad, Lilia Magomedova, Minhao Zhang, Zhengping Jia, Adam H. Metherel, Arturo Orellana, Gennady Poda, Richard P. Bazinet, Liliana Attisano, Carolyn L. Cummins, Hui Peng, Henry M. Krause
Summary: The nuclear receptor PPAR-α is an important target in the brain for the treatment of cognitive disorders. Researchers have identified an endogenous ligand, 7(S)-HDHA, that activates PPAR-α and promotes neuronal growth and synaptic plasticity.
Article
Multidisciplinary Sciences
Diwen Yang, Qifan Liu, Sizhi Wang, Matin Bozorg, Jiabao Liu, Pranav Nair, Patrick Balaguer, Datong Song, Henry Krause, Boualem Ouazia, Jonathan P. D. Abbatt, Hui Peng
Summary: With the use of protein affinity purification and mass spectrometry analysis, a previously unrecognized class of indoor transformation products formed through gas-surface reactions with nitrous acid (HONO) was identified. The study discovered nitrated bisphenol A (BPA) in house dust extracts, which showed strong binding to estrogen-related receptor y. The researchers also demonstrated a selective heterogeneous indoor chemical transformation that likely occurs between gaseous HONO and surface-bound BPA. In addition, 110 nitration products with distinct aromatic moieties were found from indoor contaminants. This study highlights the importance of incorporating indoor HONO reactions in the risk evaluation of indoor contaminants, particularly bisphenols.
Article
Biochemistry & Molecular Biology
Oscar E. E. Vasquez, Aaron M. M. Allen, Anthony K. -C. So, Quynh H. H. Nguyen, Henry M. M. Krause, Joel D. D. Levine, Marla B. B. Sokolowski
Summary: The foraging gene in Drosophila melanogaster encodes a cGMP-dependent protein kinase (PKG), which plays a crucial role in the regulation of behavior and metabolic traits. Despite its well-known role at the transcript level, little is known about the protein level of the for gene. In this study, we provide a detailed characterization of the for gene protein (FOR) products and introduce new tools for studying them, including isoform-specific antibodies and a transgenic strain. Our results reveal the expression patterns of multiple FOR isoforms and their differences in different developmental stages, larval organs, and allelic variants, providing a foundation for further exploring their functional significance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Andrew R. Burns, Rachel J. Baker, Megan Kitner, Jessica Knox, Brittany Cooke, Jonathan R. Volpatti, Aditya S. Vaidya, Emily Puumala, Bruna M. Palmeira, Elizabeth M. Redman, Jamie Snider, Sagar Marwah, Sai W. Chung, Margaret H. MacDonald, Jens Tiefenbach, Chun Hu, Qi Xiao, Constance A. M. Finney, Henry M. Krause, Sonya A. MacParland, Igor Stagljar, John S. Gilleard, Leah E. Cowen, Susan L. F. Meyer, Sean R. Cutler, James J. Dowling, Mark Lautens, Inga Zasada, Peter J. Roy
Summary: Parasitic nematodes pose a major threat to global food security, especially as the world population is set to reach 10 billion. Traditional nematicides have been banned due to their poor selectivity, leaving farmers with limited means of pest control. This study identifies a family of selective imidazothiazole nematicides, called selectivins, which undergo cytochrome P450-mediated bioactivation in nematodes.
Article
Biology
Amelie A. Raz, Gabriela S. Vida, Sarah R. Stern, Sharvani Mahadevaraju, Jaclyn M. Fingerhut, Jennifer M. Viveiros, Soumitra Pal, Jasmine R. Grey, Mara R. Grace, Cameron W. Berry, Hongjie Li, Jasper Janssens, Wouter Saelens, Zhantao Shao, Chun Hu, Yukiko M. Yamshita, Teresa Przytycka, Brian Oliver, Julie A. Brill, Henry Krause, Erika L. Matunis, Helen White-Cooper, Stephen DiNardo, Margaret T. Fuller, Michael Buszczak
Summary: We provide a comprehensive single nucleus and single cell RNA-seq resource for spermatogenesis in Drosophila, obtained from the analysis of adult testis single nucleus RNA-seq (snRNA-seq) data. This dataset includes over 44,000 nuclei and 6000 cells, allowing for the identification of rare cell types, mapping of intermediate steps in differentiation, and the potential discovery of new factors impacting fertility or controlling differentiation.
Correction
Microbiology
Robert J. Evans, Katherine Pline, Catherine A. Loynes, Sarah Needs, Maceler Aldrovandi, Jens Tiefenbach, Ewa Bielska, Rachel E. Rubino, Christopher J. Nicol, Robin C. May, Henry M. Krause, Valerie B. O'Donnell, Stephen A. Renshaw, Simon A. Johnston
