PKR deficiency alters E. coli-induced sickness behaviors but does not exacerbate neuroimmune responses or bacterial load

The transcription factor nuclear factor interleukin 6 mediates pro- and anti-inflammatory responses during LPS-induced systemic inflammation in mice

(2015) Jenny Schneiders et al.   BRAIN BEHAVIOR AND IMMUNITY

Sickness: From the focus on cytokines, prostaglandins, and complement factors to the perspectives of neurons

(2015) David Chun-Hei Poon et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model

(2015) F Mouton-Liger et al.   Cell Death & Disease

Innate Responses to Systemic Infection by Intracellular Bacteria Trigger Recruitment of Ly-6Chigh Monocytes to the Brain

(2014) D. A. Drevets et al.   JOURNAL OF IMMUNOLOGY

PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis

(2014) Parul Kapil et al.   JOURNAL OF NEUROIMMUNOLOGY

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Local and systemic neutrophilic inflammation in patients with lung cancer and chronic obstructive pulmonary disease

(2013) Neringa Vaguliene et al.   BMC IMMUNOLOGY

CRH: The link between hormonal-, metabolic- and behavioral responses to stress

(2013) Krisztina J. Kovács   JOURNAL OF CHEMICAL NEUROANATOMY

Cyclooxygenase-1-Dependent Prostaglandins Mediate Susceptibility to Systemic Inflammation-Induced Acute Cognitive Dysfunction

(2013) E. W. Griffin et al.   JOURNAL OF NEUROSCIENCE

Role of brain transmigrating neutrophils in depression-like behavior during systemic infection

(2013) A Aguliar-Valles et al.   MOLECULAR PSYCHIATRY

The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component

(2013) C. Tronel et al.   NEUROCHEMISTRY INTERNATIONAL

Correction: A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 Mice

(2013) Donal T. Skelly et al.   PLoS One

The Protein Kinase Double-Stranded RNA-Dependent (PKR) Enhances Protection against Disease Cause by a Non-Viral Pathogen

(2013) Pauline Sebby Ogolla et al.   PLoS Pathogens

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways

(2012) Michael Maes et al.   BMC Medicine

At the extreme end of the psychoneuroimmunological spectrum: Delirium as a maladaptive sickness behaviour response

(2012) Colm Cunningham et al.   BRAIN BEHAVIOR AND IMMUNITY

PKR stirs up inflammasomes

(2012) H James Stunden et al.   CELL RESEARCH

Glucocorticoid receptor dimerization is required for proper recovery of LPS-induced inflammation, sickness behavior and metabolism in mice

(2012) M N Silverman et al.   MOLECULAR PSYCHIATRY

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

Immune surveillance in the central nervous system

(2012) Shalina S Ousman et al.   NATURE NEUROSCIENCE

Cytokines: How important are they in mediating sickness?

(2012) David Chun-Hei Poon et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

PKR-Dependent Inflammatory Signals

(2012) R. Kang et al.   Science Signaling

Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition

(2011) Ping Jun Zhu et al.   CELL

Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures

(2011) J Couturier et al.   Journal of Neuroinflammation

Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6

(2011) Carol L Murray et al.   Journal of Neuroinflammation

Glutamatergic and Dopaminergic Neurons Mediate Anxiogenic and Anxiolytic Effects of CRHR1

(2011) D. Refojo et al.   SCIENCE

Ascending caudal medullary catecholamine pathways drive sickness-induced deficits in exploratory behavior: Brain substrates for fatigue?

(2010) Ronald P.A. Gaykema et al.   BRAIN BEHAVIOR AND IMMUNITY

Modulation of Tau Phosphorylation by the Kinase PKR: Implications in Alzheimer's Disease

(2010) Anindita Bose et al.   BRAIN PATHOLOGY

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Involvement of nitric oxide in lipopolysaccharide induced anorexia

(2010) Thomas Riediger et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Differences in the relative involvement of peripherally released interleukin (IL)-6, brain IL-1β and prostanoids in mediating lipopolysaccharide-induced fever and sickness behavior

(2010) Lois M. Harden et al.   PSYCHONEUROENDOCRINOLOGY

Burrowing: A sensitive behavioural assay, tested in five species of laboratory rodents

(2009) R.M.J. Deacon   BEHAVIOURAL BRAIN RESEARCH

Characterization of the sickness response in young and aging rats following E. coli infection

(2009) Ruth M. Barrientos et al.   BRAIN BEHAVIOR AND IMMUNITY

The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: Implications for a role of COX-1

(2009) J.L. Teeling et al.   BRAIN BEHAVIOR AND IMMUNITY

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Cytokine, Sickness Behavior, and Depression

(2009) Robert Dantzer   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response

(2009) G. Barry et al.   JOURNAL OF GENERAL VIROLOGY

Role of Endothelial TLR4 for Neutrophil Recruitment into Central Nervous System Microvessels in Systemic Inflammation

(2009) H. Zhou et al.   JOURNAL OF IMMUNOLOGY

Cerebral Microglia Recruit Monocytes into the Brain in Response to Tumor Necrosis Factor  Signaling during Peripheral Organ Inflammation

(2009) C. D'Mello et al.   JOURNAL OF NEUROSCIENCE

Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation

(2009) C Rummel et al.   MOLECULAR PSYCHIATRY

Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease

(2008) Colm Cunningham et al.   BIOLOGICAL PSYCHIATRY

Interleukin (IL)-6 and IL-1β act synergistically within the brain to induce sickness behavior and fever in rats

(2008) Lois M. Harden et al.   BRAIN BEHAVIOR AND IMMUNITY

Circadian pattern of total and free corticosterone concentrations, corticosteroid-binding globulin, and physical activity in mice selectively bred for high voluntary wheel-running behavior

(2008) Jessica L. Malisch et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Blockade of the V1b receptor reduces ACTH, but not corticosterone secretion induced by stress without affecting basal hypothalamic–pituitary–adrenal axis activity

(2008) Francesca Spiga et al.   JOURNAL OF ENDOCRINOLOGY

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

(2008) Christopher J Henry et al.   Journal of Neuroinflammation

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFα-induced sickness behavior

(2008) Karine Palin et al.   PSYCHOPHARMACOLOGY

PKR Regulates TLR2/TLR4-Dependent Signaling in Murine Alveolar Macrophages

(2007) Maciej Cabanski et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE