PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Automatic counting and positioning of 5-bromo-2-deoxyuridine (BrdU) positive cells in cortical layers of rat brain slices

(2014) Martin Schmuck et al.   NEUROTOXICOLOGY

Proteostasis Impairment: At the Intersection between Alzheimer’s Disease and Diabetes

(2013) Danilo B. Medinas et al.   Cell Metabolism

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Autophagy alleviates neurodegeneration caused by mild impairment of oxidative metabolism

(2013) Ya Meng et al.   JOURNAL OF NEUROCHEMISTRY

Nitro-Oxidative Stress after Neuronal Ischemia Induces Protein Nitrotyrosination and Cell Death

(2013) Marta Tajes et al.   Oxidative Medicine and Cellular Longevity

Cerebrospinal Fluid PKR Level Predicts Cognitive Decline in Alzheimer’s Disease

(2013) Julien Dumurgier et al.   PLoS One

Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway

(2012) François Mouton-Liger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Increased Cerebrospinal Fluid Levels of Double-Stranded RNA-Dependant Protein Kinase in Alzheimer's Disease

(2012) François Mouton-Liger et al.   BIOLOGICAL PSYCHIATRY

Cytoplasmic STAT3 Represses Autophagy by Inhibiting PKR Activity

(2012) Shensi Shen et al.   MOLECULAR CELL

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

The PKR Activator PACT Is Induced by Aβ: Involvement in Alzheimer's Disease

(2011) Claire Paquet et al.   BRAIN PATHOLOGY

Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition

(2011) Ping Jun Zhu et al.   CELL

Activation of PKR Causes Amyloid ß-Peptide Accumulation via De-Repression of BACE1 Expression

(2011) Gerard ILL-Raga et al.   PLoS One

Modulation of Tau Phosphorylation by the Kinase PKR: Implications in Alzheimer's Disease

(2010) Anindita Bose et al.   BRAIN PATHOLOGY

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death

(2010) P Peidis et al.   CELL DEATH AND DIFFERENTIATION

eIF2  Phosphorylation-Dependent Translation in CA1 Pyramidal Cells Impairs Hippocampal Memory Consolidation without Affecting General Translation

(2010) Z. Jiang et al.   JOURNAL OF NEUROSCIENCE

Exposure to Pyrithiamine Increases β-Amyloid Accumulation, Tau Hyperphosphorylation, and Glycogen Synthase Kinase-3 Activity in the Brain

(2010) Jing Zhao et al.   NEUROTOXICITY RESEARCH

Organization and morphology of thalamocortical neurons of mouse ventral lateral thalamus

(2010) Aileen P. Tlamsa et al.   SOMATOSENSORY AND MOTOR RESEARCH

Neuronal Phosphorylated RNA-Dependent Protein Kinase in Creutzfeldt-Jakob Disease

(2009) Claire Paquet et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Thiamine deficiency increases β-secretase activity and accumulation of β-amyloid peptides

(2009) Qipeng Zhang et al.   NEUROBIOLOGY OF AGING

Oxidative stress induces PKR-dependent apoptosis via IFN-γ activation signaling in Jurkat T cells

(2008) Chul-Woong Pyo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model

(2008) Saravanan S. Karuppagounder et al.   NEUROBIOLOGY OF AGING

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

(2008) Tracy O'Connor et al.   NEURON