Article
Neurosciences
Katryna Pampuscenko, Ramune Morkuniene, Lukas Krasauskas, Vytautas Smirnovas, Taisuke Tomita, Vilmante Borutaite
Summary: Recent experimental models have shown a link between extracellular tau and neurodegeneration, but the exact mechanisms by which extracellular tau induces neuronal death remain unclear. This study found that extracellular phosphorylated tau(2N4R) is the most toxic form, causing neuronal loss at low nanomolar concentrations, and the neurotoxicity of tau(1N4R) depends on its aggregation state.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Sheng Zhang, Man Zhai, Yiwei Xu, Jiandong Han, Jiaxin Chen, Yucui Xiong, Shihua Pan, Qizheng Wang, Chunlai Yu, Zilong Rao, Qi Sun, Yufei Sui, Ke Fan, Heying Li, Wenjing Guo, Cuicui Liu, Ying Bai, Jing Zhou, Daping Quan, Xiao Zhang
Summary: Astrocytes, the most abundant and widespread glial cells in the central nervous system, play a crucial role in spinal cord injury repair. Decellularised spinal cord matrix (DSCM) has potential for SCI repair, but its specific mechanisms and niche alterations are not well understood. This study utilized single-cell RNA sequencing to investigate the regulatory mechanisms of DSCM on the glial niche in the neuro-glial-vascular unit.
CELL PROLIFERATION
(2023)
Article
Immunology
Yin Yuxiong, Xiang Xujin, Tang Yi, Chen Ya, Li Yujuan, Hu Shanshan, Wang Huiwen
Summary: Neuronal death and neuroinflammation are important factors in the progression of traumatic brain injury (TBI). This study reveals that a protein called TRAF7 plays a critical role in TBI by regulating cell death and inflammation. The interaction between TRAF7 and MEKK3 is a key step in the development of TBI, suggesting that TRAF7 could be a potential therapeutic target for TBI treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Virology
Mazigh Fares, Kamila Gorna, Noemie Berry, Marielle Cochet-Bernoin, Francois Piumi, Odile Blanchet, Nadia Haddad, Jennifer Richardson, Muriel Coulpier
Summary: TBEV infection can lead to neurological symptoms that may cause permanent disability or death. Using a pathological model based on human neuronal/glial cells and transcriptomic approaches, the study found that neuronal death in TBEV-infected cells may occur through multiple mechanisms.
Review
Biochemistry & Molecular Biology
Guy C. Brown
Summary: After a stroke, rapid necrosis of cells in the infarct occurs, followed by delayed loss of neurons due to microglial phagocytosis, which may be prevented by targeting phagocytic receptors on microglia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Shu-Chao Wang, Xi-Min Hu, Kun Xiong
Summary: This paper reviews the role of Pin1 in regulated cell death and summarizes Pin1-related pathways. In addition to apoptosis in neurodegenerative diseases, Pin1 is also involved in regulated necrosis and autophagy, exhibiting distinct effects including both neurotoxic and neuroprotective effects. Understanding Pin1 in neuronal death may lead to the development of new therapeutic options for neurodegenerative disorders.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Stefan Milde, Guy C. Brown
Summary: This study suggests that microglial phagocytosis of stressed neurons mediated by P2Y(6) receptor plays a role in the delayed neuronal loss after stroke, and targeting the P2Y(6) receptor could potentially prevent peri-infarct neuronal loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sergio B. Velarde, Alvaro Quevedo, Carlos Estella, Antonio Baonza
Summary: Damage in the nervous system triggers a stereotypical response mediated by glial cells, as shown in the Drosophila melanogaster eye disc model. This response, controlled by the Dpp and Hh signaling pathways, involves glial cell proliferation and migration after cell death induction, with the latter process depending on the JNK pathway activation. The findings suggest a common mechanism controlling glial cell response in different regions of the peripheral nervous system upon neuronal cell death induction.
Article
Biochemistry & Molecular Biology
Azizul Haque, Kelsey P. Drasites, April Cox, Mollie Capone, Ali Myatich, Ramsha Shams, Denise Matzelle, Dena P. Garner, Mikhail Bredikhin, Donald C. Shields, Alexey Vertegel, Naren L. Banik
Summary: The study demonstrates that local delivery of E2 via nanoparticles to the injured spinal cord can reduce inflammation and improve functional outcomes following SCI.
NEUROCHEMICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shatakshi Shukla, Fatema Currim, Jyoti Singh, Shanikumar Goyani, M. V. Saranga, Anjali Shinde, Minal Mane, Nisha Chandak, Shyam Kishore, Rajesh Singh
Summary: Parkinson's disease is a progressive neurodegenerative disorder characterized by dopaminergic neuronal cell death. Exosomes, which play a crucial role in the progression and pathogenesis of PD, facilitate communication between different cell types in the brain. The release of exosomes is enhanced by dysfunctional neurons/glia under PD stress and mediates the transfer of biomolecules between different cell types in the brain.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Cell Biology
Zhi-Lai Zhou, Huan Xie, Xiao-Bo Tian, Hua-Li Xu, Wei Li, Shun Yao, Hui Zhang
Summary: Microglial depletion impairs astrocyte proliferation and scar formation, and induces inflammatory diffusion partly by inhibiting STAT3 phosphorylation in astrocytes following spinal cord injury.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biology
Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin, Yong Huang, Yuki Yoshioka, Christian J. F. Bertens, Kohei Tsumaki, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hiroyasu Akalsu, Naoki Atsuta, Masahisa Katsuno, Katsutoshi Furukawa, Aiko Ishiki, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Takanori Yokota, Haruhisa Inoue, Hiroyuki Arai, Gen Sobue, Masaki Sone, Kyota Fujita, Hitoshi Okazawa
Summary: The early-stage mechanisms of neuronal necrosis in VCPT262A-KI mice with FTLD have been discovered, and potential rescue through in utero gene therapy has been suggested. YAP-dependent necrosis was also found in neurons of FTLD patients, with pSer46-MARCKS as a specific marker for this process.
LIFE SCIENCE ALLIANCE
(2021)
Article
Biochemistry & Molecular Biology
Yu Zhai, Shi-Yang Ye, Qiu-Shi Wang, Ren-Ping Xiong, Sheng-Yu Fu, Hao Du, Ya-Wei Xu, Yan Peng, Zhi-Zhong Huang, Nan Yang, Yan Zhao, Ya-Lei Ning, Ping Li, Yuan-Guo Zhou
Summary: This study found that ski overexpression after TBI can promote neurorestoration, facilitate neuronal regeneration, and reduce astrogliosis. These results suggest that ski may be an effective neurorestorative gene.
Article
Neurosciences
Rafael Teixeira Ribeiro, Bianca Seminotti, Angela Zanatta, Francine Hehn de Oliveira, Alexandre Umpierrez Amaral, Guilhian Leipnitz, Moacir Wajner
Summary: D-2-HG induces neurotoxicity in neonatal rats, leading to cell damage and oxidative stress, which may be related to the pathomechanisms of D-2-HGA.
Article
Cell Biology
Qing Ye, Pranay Srivastava, Nasser Al-Kuwari, Xiqun Chen
Summary: This study characterizes the effects of BRAF(V600E) mutation on cell death and proliferation in different cell types of the central nervous system. It reveals that BRAF(V600E) induces cell proliferation in astrocytes and microglia, while directly causing neuronal death. These effects are mediated by different downstream effectors.
NEURAL REGENERATION RESEARCH
(2023)