Pharmaco- and toxicokinetics of selected exogenous and endogenous estrogens: A review of the data and identification of knowledge gaps

Bisphenol A and indicators of obesity, glucose metabolism/type 2 diabetes and cardiovascular disease: A systematic review of epidemiologic research

(2014) Judy S. LaKind et al.   CRITICAL REVIEWS IN TOXICOLOGY

Comparative pharmacokinetics and tissue distribution analysis of systemically administered 17-β-estradiol and its metabolites in vivo delivered using a cationic nanoemulsion or a peptide-modified nanoemulsion system for targeting atherosclerosis

(2014) Dipti Deshpande et al.   JOURNAL OF CONTROLLED RELEASE

Urinary Isoflavone Concentrations Are Inversely Associated with Cardiometabolic Risk Markers in Pregnant U.S. Women

(2014) Ling Shi et al.   JOURNAL OF NUTRITION

Bisphenol A (BPA) pharmacokinetics with daily oral bolus or continuous exposure via silastic capsules in pregnant rhesus monkeys: Relevance for human exposures

(2014) Frederick S. vom Saal et al.   REPRODUCTIVE TOXICOLOGY

Comparison of Life-Stage-Dependent Internal Dosimetry for Bisphenol A, Ethinyl Estradiol, a Reference Estrogen, and Endogenous Estradiol to Test an Estrogenic Mode of Action in Sprague Dawley Rats

(2014) Mona I. Churchwell et al.   TOXICOLOGICAL SCIENCES

The Mortality Toll of Estrogen Avoidance: An Analysis of Excess Deaths Among Hysterectomized Women Aged 50 to 59 Years

(2013) Philip M. Sarrel et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Menopausal Hormone Therapy for the Primary Prevention of Chronic Conditions: A Systematic Review to Update the U.S. Preventive Services Task Force Recommendations

(2013) Heidi D. Nelson et al.   ANNALS OF INTERNAL MEDICINE

Menopausal Hormone Therapy for the Primary Prevention of Chronic Conditions: U.S. Preventive Services Task Force Recommendation Statement

(2013) Virginia A. Moyer   ANNALS OF INTERNAL MEDICINE

Soy and Its Isoflavones: The Truth Behind the Science in Breast Cancer

(2013) Crystal Douglas et al.   Anti-Cancer Agents in Medicinal Chemistry

Equol, Adiponectin, Insulin Levels and Risk of Breast Cancer

(2013) Machiko Minatoya et al.   Asian Pacific Journal of Cancer Prevention

Equol-Producing Status, Isoflavone Intake, and Breast Density in a Sample of U.S. Chinese Women

(2013) M. Tseng et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

The importance of pharmacokinetic studies in drug development

(2013) David F. Archer   CONTRACEPTION

Ethinyl estradiol and 17β-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment

(2013) Frank Z. Stanczyk et al.   CONTRACEPTION

Exposure Conditions and Pharmacokinetic Principles: Interpreting Bisphenol A Absorption in the Canine Oral Cavity

(2013) Justin G. Teeguarden et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Potential External Contamination with Bisphenol A and Other Ubiquitous Organic Environmental Chemicals during Biomonitoring Analysis: An Elusive Laboratory Challenge

(2013) Xiaoyun Ye et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The pharmacokinetics and pharmacodynamics of dehydroepiandrosterone during use of an ethinylestradiol- and drospirenone-containing oral contraceptive

(2013) Yvette Zimmerman et al.   EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE

A systematic review of Bisphenol A “low dose” studies in the context of human exposure: A case for establishing standards for reporting “low-dose” effects of chemicals

(2013) Justin G. Teeguarden et al.   FOOD AND CHEMICAL TOXICOLOGY

Are typical human serum BPA concentrations measurable and sufficient to be estrogenic in the general population?

(2013) Justin Teeguarden et al.   FOOD AND CHEMICAL TOXICOLOGY

The Women’s Health Initiative—A Victory for Women and Their Health

(2013) Elizabeth G. Nabel   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Menopausal Hormone Therapy and Health Outcomes During the Intervention and Extended Poststopping Phases of the Women’s Health Initiative Randomized Trials

(2013) JoAnn E. Manson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Development of a Method for the Determination of Bisphenol A at Trace Concentrations in Human Blood and Urine and Elucidation of Factors Influencing Method Accuracy and Sensitivity

(2013) Dan Alan Markham et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Pharmacology of conjugated equine estrogens: Efficacy, safety and mechanism of action

(2013) Bhagu R. Bhavnani et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Population pharmacokinetic/pharmacodynamic evaluation of low-dose drospirenone with 17β-estradiol in postmenopausal women with moderate to severe vasomotor symptoms

(2013) Gabriele Sutter et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Prediction and evaluation of route dependent dosimetry of BPA in rats at different life stages using a physiologically based pharmacokinetic model

(2013) Xiaoxia Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Lower Risk of Cardiovascular Events in Postmenopausal Women Taking Oral Estradiol Compared With Oral Conjugated Equine Estrogens

(2013) Nicholas L. Smith et al.   JAMA Internal Medicine

Effects on bone mineral density of a monophasic combined oral contraceptive containing nomegestrol acetate/17β-estradiol in comparison to levonorgestrel/ethinylestradiol

(2012) TERJE SØRDAL et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs?

(2012) François Bouzom et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

PBPK as a tool in regulatory review

(2012) Shiew-Mei Huang   BIOPHARMACEUTICS & DRUG DISPOSITION

Evaluation of the effects of rifampicin, ketoconazole and erythromycin on the steady-state pharmacokinetics of the components of a novel oral contraceptive containing estradiol valerate and dienogest in healthy postmenopausal women

(2012) Hartmut Blode et al.   CONTRACEPTION

Therapeutically equivalent pharmacokinetic profile across three application sites for AG200-15, a novel low-estrogen dose contraceptive patch

(2012) Frank Z. Stanczyk et al.   CONTRACEPTION

Prolonged monitoring of ethinyl estradiol and levonorgestrel levels confirms an altered pharmacokinetic profile in obese oral contraceptives users

(2012) Alison B. Edelman et al.   CONTRACEPTION

Sex Differences in the Clearance of CYP3A4 Substrates: Exploring Possible Reasons for the Substrate Dependency and Lack of Consensus

(2012) Manoranjenni Chetty et al.   CURRENT DRUG METABOLISM

Why We Need Proper PBPK Models to Examine Intestine and Liver Oral Drug Absorption

(2012) Edwin C.Y. Chow et al.   CURRENT DRUG METABOLISM

Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses

(2012) Laura N. Vandenberg et al.   ENDOCRINE REVIEWS

Pharmacokinetics of drospirenone and ethinylestradiol in Caucasian and Japanese women

(2012) Hartmut Blode et al.   EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE

Isoflavones: estrogenic activity, biological effect and bioavailability

(2012) Daniela Cristina Vitale et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Elucidation of the metabolic pathway of S-equol in rat, monkey and man

(2012) Richard J. Schwen et al.   FOOD AND CHEMICAL TOXICOLOGY

Toxicokinetics and lack of uterotropic effect of orally administered S-equol

(2012) Richard J. Schwen et al.   FOOD AND CHEMICAL TOXICOLOGY

Comparing United States and Canadian population exposures from National Biomonitoring Surveys: Bisphenol A intake as a case study

(2012) Judy S LaKind et al.   Journal of Exposure Science and Environmental Epidemiology

Minireview: Nuclear Receptor and Coregulator Proteomics—2012 and Beyond

(2012) Bert W. O'Malley et al.   MOLECULAR ENDOCRINOLOGY

Use of NHANES Data to Link Chemical Exposures to Chronic Diseases: A Cautionary Tale

(2012) Judy S. LaKind et al.   PLoS One

Low-dose effects and nonmonotonic dose–responses of endocrine disrupting chemicals: Has the case been made?

(2012) Lorenz R. Rhomberg et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Susceptibility of estrogen receptor rapid responses to xenoestrogens: Physiological outcomes

(2012) Maria Marino et al.   STEROIDS

Human and Rat ABC Transporter Efflux of Bisphenol A and Bisphenol A Glucuronide: Interspecies Comparison and Implications for Pharmacokinetic Assessment

(2012) Christopher S. Mazur et al.   TOXICOLOGICAL SCIENCES

Concurrent determination of bisphenol A pharmacokinetics in maternal and fetal rhesus monkeys

(2012) Tucker A. Patterson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pharmacokinetics of bisphenol A in serum and adipose tissue following intravenous administration to adult female CD-1 mice

(2012) Daniel R. Doerge et al.   TOXICOLOGY LETTERS

G protein-coupled oestrogen receptor 1 (GPER1)/GPR30: a new player in cardiovascular and metabolic oestrogenic signalling

(2011) Bengt-Olof Nilsson et al.   BRITISH JOURNAL OF PHARMACOLOGY

Comparative pharmacokinetics and pharmacodynamics after subcutaneous and intramuscular administration of medroxyprogesterone acetate (25 mg) and estradiol cypionate (5 mg)

(2011) José Alfredo Sierra-Ramírez et al.   CONTRACEPTION

Ethinyl estradiol and levonorgestrel pharmacokinetics with a low-dose transdermal contraceptive delivery system, AG200-15: a randomized controlled trial

(2011) David F. Archer et al.   CONTRACEPTION

Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A

(2011) J. G. Hengstler et al.   CRITICAL REVIEWS IN TOXICOLOGY

Assessing the Quantitative Relationships between Preschool Children’s Exposures to Bisphenol A by Route and Urinary Biomonitoring

(2011) Marsha K. Morgan et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Widespread Occurrence of Bisphenol A in Paper and Paper Products: Implications for Human Exposure

(2011) Chunyang Liao et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Physiologically Based Pharmacokinetic Modeling: Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development

(2011) Feras Khalil et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Sex Differences in Drug Disposition

(2011) Offie P. Soldin et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Oral Contraceptive Use and Bone Density Change in Adolescent and Young Adult Women: A Prospective Study of Age, Hormone Dose, and Discontinuation

(2011) Delia Scholes et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Physiologically Based Pharmacokinetic Tissue Compartment Model Selection in Drug Development and Risk Assessment

(2011) Matthew D. Thompson et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects

(2011) Beverly S. Rubin   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Simultaneous quantification of bisphenol A and its glucuronide metabolite (BPA-G) in plasma and urine: Applicability to toxicokinetic investigations

(2011) M.Z. Lacroix et al.   TALANTA

Twenty-Four Hour Human Urine and Serum Profiles of Bisphenol A during High-Dietary Exposure

(2011) Justin G. Teeguarden et al.   TOXICOLOGICAL SCIENCES

Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague–Dawley rats

(2011) Daniel R. Doerge et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pharmacokinetic modeling: Prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans

(2011) Jeffrey W. Fisher et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pharmacokinetics of Bisphenol A in neonatal and adult CD-1 mice: Inter-species comparisons with Sprague-Dawley rats and rhesus monkeys

(2011) Daniel R. Doerge et al.   TOXICOLOGY LETTERS

Application of PBPK modelling in drug discovery and development at Pfizer

(2011) Hannah M Jones et al.   XENOBIOTICA

Evaluating Pharmacokinetic and Pharmacodynamic Interactions with Computational Models in Supporting Cumulative Risk Assessment

(2011) Yu-Mei Tan et al.   International Journal of Environmental Research and Public Health

Structural Overview of the Nuclear Receptor Superfamily: Insights into Physiology and Therapeutics

(2010) Pengxiang Huang et al.   Annual Review of Physiology

NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

(2010) Robert E. Chapin et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Endocrine Disrupting Chemicals Targeting Estrogen Receptor Signaling: Identification and Mechanisms of Action

(2010) Erin K. Shanle et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Steady-state pharmacokinetics of an extended-regimen oral contraceptive with continuous estrogen

(2010) Charles E. DiLiberti et al.   CONTRACEPTION

Antibiotics and oral contraceptive failure — a case-crossover study

(2010) Sengwee Toh et al.   CONTRACEPTION

Estrogenic Activity of Bisphenol A and 2,2-bis( p -Hydroxyphenyl)-1,1,1-trichloroethane (HPTE) Demonstrated in Mouse Uterine Gene Profiles

(2010) Sylvia C. Hewitt et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Similarity of Bisphenol A Pharmacokinetics in Rhesus Monkeys and Mice: Relevance for Human Exposure

(2010) Julia A. Taylor et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Determination of free and total bisphenol A in urine of infants

(2010) Wolfgang Völkel et al.   ENVIRONMENTAL RESEARCH

Relationship Between Urine Bisphenol-A Level and Declining Male Sexual Function

(2010) D.-K. Li et al.   JOURNAL OF ANDROLOGY

Prevalence of the Equol-Producer Phenotype and Its Relationship with Dietary Isoflavone and Serum Lipids in Healthy Chinese Adults

(2010) Baohua Liu et al.   JOURNAL OF EPIDEMIOLOGY

Daily intake of bisphenol A and potential sources of exposure: 2005–2006 National Health and Nutrition Examination Survey

(2010) Judy S LaKind et al.   Journal of Exposure Science and Environmental Epidemiology

Equol: Pharmacokinetics and Biological Actions

(2010) Kenneth D. R. Setchell et al.   JOURNAL OF NUTRITION

Equol: History, Chemistry, and Formation

(2010) Kenneth D. R. Setchell et al.   JOURNAL OF NUTRITION

Assessment of Bisphenol a Exposure in Korean Pregnant Women by Physiologically Based Pharmacokinetic Modeling

(2010) Beom Soo Shin et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

A randomized, multiple-dose parallel study to compare the pharmacokinetic parameters of synthetic conjugated estrogens, A, administered as oral tablet or vaginal cream

(2010) Rupinder K. Bhamra et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Association of Urinary Bisphenol A Concentration with Heart Disease: Evidence from NHANES 2003/06

(2010) David Melzer et al.   PLoS One

Is equol production beneficial to health?

(2010) Pamela J. Magee   PROCEEDINGS OF THE NUTRITION SOCIETY

Biomonitoring Equivalents for bisphenol A (BPA)

(2010) Kannan Krishnan et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic☆☆☆

(2010) John D. Meeker et al.   REPRODUCTIVE TOXICOLOGY

Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys

(2010) Daniel R. Doerge et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats

(2010) Daniel R. Doerge et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The pharmacokinetic behavior of the soy isoflavone metabolite S-(−)equol and its diastereoisomer R-(+)equol in healthy adults determined by using stable-isotope-labeled tracers

(2009) Kenneth DR Setchell et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Is equol the key to the efficacy of soy foods?

(2009) Johanna W Lampe   AMERICAN JOURNAL OF CLINICAL NUTRITION

The Dual, Opposing Roles of Estrogen in the Prostate

(2009) Stuart J. Ellem et al.   Annals of the New York Academy of Sciences

Sex Differences in Pharmacokinetics and Pharmacodynamics

(2009) Offie P. Soldin et al.   CLINICAL PHARMACOKINETICS

Oral contraceptive use and bone density in adolescent and young adult women

(2009) Delia Scholes et al.   CONTRACEPTION

Does Rapid Metabolism Ensure Negligible Risk from Bisphenol A?

(2009) Gary Ginsberg et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Steady-State Pharmacokinetics Following Application of a Novel Transdermal Estradiol Spray in Healthy Postmenopausal Women

(2009) Terri L. Morton et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The Pharmacokinetics of S-(-)Equol Administered as SE5-OH Tablets to Healthy Postmenopausal Women

(2009) Kenneth D. R. Setchell et al.   JOURNAL OF NUTRITION

Prostatic soy isoflavone concentrations exceed serum levels after dietary supplementation

(2009) Christopher D. Gardner et al.   PROSTATE

Isoflavone supplements stimulated the production of serum equol and decreased the serum dihydrotestosterone levels in healthy male volunteers

(2009) M Tanaka et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Novel ethinyl estradiol-beta-cyclodextrin clathrate formulation does not influence the relative bioavailability of ethinyl estradiol or coadministered drospirenone

(2008) Hartmut Blode et al.   CONTRACEPTION

Oral contraceptives and individual variability of circulating levels of ethinyl estradiol and progestins

(2008) Joseph W. Goldzieher et al.   CONTRACEPTION

The Key Importance of Soy Isoflavone Bioavailability to Understanding Health Benefits

(2008) Theresa Larkin et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants

(2008) Birgit Holst et al.   CURRENT OPINION IN BIOTECHNOLOGY

Structure Activity Relationships and Differential Interactions and Functional Activity of Various Equine Estrogens Mediated via Estrogen Receptors (ERs) ERα and ERβ

(2008) Bhagu R. Bhavnani et al.   ENDOCRINOLOGY

Bisphenol A at Environmentally Relevant Doses Inhibits Adiponectin Release from Human Adipose Tissue Explants and Adipocytes

(2008) Eric R. Hugo et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Association of Urinary Bisphenol A Concentration With Medical Disorders and Laboratory Abnormalities in Adults

(2008) Iain A. Lang   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Bisphenol A (BPA) daily intakes in the United States: Estimates from the 2003–2004 NHANES urinary BPA data

(2008) Judy S Lakind et al.   Journal of Exposure Science and Environmental Epidemiology

Assessing and Managing Risks Arising from Exposure to Endocrine-Active Chemicals

(2008) Karen P. Phillips et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Derivation of a Bisphenol a Oral Reference Dose (RfD) and Drinking-Water Equivalent Concentration∗

(2008) Calvin C. Willhite et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

The ontogeny of drug metabolism enzymes and implications for adverse drug events

(2008) Ronald N. Hines   PHARMACOLOGY & THERAPEUTICS

Determination of free and total bisphenol A in human urine to assess daily uptake as a basis for a valid risk assessment

(2008) Wolfgang Völkel et al.   TOXICOLOGY LETTERS