Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs?

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

(2011) Malcolm Rowland et al.   Annual Review of Pharmacology and Toxicology

PBPK Modeling of Intestinal and Liver Enzymes and Transporters in Drug Absorption and Sequential Metabolism

(2011) Jianghong Fan et al.   CURRENT DRUG METABOLISM

The Impact of Hepatic Uptake on the Pharmacokinetics of Organic Anions

(2011) P. Gardiner et al.   DRUG METABOLISM AND DISPOSITION

Physiologically Based Pharmacokinetic Modeling: Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development

(2011) Feras Khalil et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Lead PK Commentary: Predicting Human Pharmacokinetics

(2011) Malcolm Rowland et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics, Part 1: Goals, Properties of the Phrma Dataset, and Comparison with Literature Datasets

(2011) Patrick Poulin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: Prediction of plasma concentration–time profiles in human from in vivo preclinical data by using the Wajima approach

(2011) Ragini Vuppugalla et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

(2011) Patrick Poulin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: Comparative assessement of prediction methods of human clearance

(2011) Barbara J. Ring et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: Comparative assessment of prediction methods of human volume of distribution

(2011) Rhys Do Jones et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Predictions of Metabolic Drug-Drug Interactions Using Physiologically Based Modelling

(2010) Nathalie Perdaems et al.   CLINICAL PHARMACOKINETICS

A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance

(2010) Trevor N. Johnson et al.   CLINICAL PHARMACOKINETICS

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

(2010) P Zhao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion

(2010) K. Sandy Pang et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans

(2010) Takao Watanabe et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Physiological Modeling to Understand the Impact of Enzymes and Transporters on Drug and Metabolite Data and Bioavailability Estimates

(2010) Huadong Sun et al.   PHARMACEUTICAL RESEARCH

Model Analysis of the Concentration-Dependent Permeability of P-gp Substrates

(2010) Tatsuhiko Tachibana et al.   PHARMACEUTICAL RESEARCH

Population-Based Mechanistic Prediction of Oral Drug Absorption

(2009) Masoud Jamei et al.   AAPS Journal

A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

(2009) Masoud Jamei et al.   Drug Metabolism and Pharmacokinetics

Physiologically based pharmacokinetics (PBPK)

(2009) Pascal Espié et al.   DRUG METABOLISM REVIEWS

Physiologically based mechanistic modelling to predict complex drug–drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut—The effect of diltiazem on the time-course of exposure to triazolam

(2009) Karen Rowland Yeo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Physiology-Based Simulations of a Pathological Condition

(2008) Andrea N Edginton et al.   CLINICAL PHARMACOKINETICS

Functional Consequences of Active Hepatic Uptake on Cytochrome P450 Inhibition in Rat and Human Hepatocytes

(2008) K. Grime et al.   DRUG METABOLISM AND DISPOSITION

Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin, and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes

(2008) S. W. Paine et al.   DRUG METABOLISM AND DISPOSITION

Pharmacokinetic predictions in children by using the physiologically based pharmacokinetic modelling

(2008) F. Bouzom et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans

(2008) T. Watanabe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Applications of Physiologically Based Absorption Models in Drug Discovery and Development

(2008) Neil Parrott et al.   MOLECULAR PHARMACEUTICS