Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration

(2013) Daniel J. Nolan et al.   DEVELOPMENTAL CELL

Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization

(2013) Donna M. Small et al.   INTERNATIONAL JOURNAL OF CANCER

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Tight Junction in Blood-Brain Barrier: An Overview of Structure, Regulation, and Regulator Substances

(2012) Wei-Ye Liu et al.   CNS Neuroscience & Therapeutics

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

Astrocyte-Specific Expression Patterns Associated with the PDGF-Induced Glioma Microenvironment

(2012) Amanda M. Katz et al.   PLoS One

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

(2011) T. Shree et al.   GENES & DEVELOPMENT

Proteomic Identification of Protease Cleavage Sites Characterizes Prime and Non-prime Specificity of Cysteine Cathepsins B, L, and S

(2011) Martin L. Biniossek et al.   JOURNAL OF PROTEOME RESEARCH

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

(2011) Thordur Oskarsson et al.   NATURE MEDICINE

Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis

(2011) E. S. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteolytic networks in cancer

(2011) Steven D. Mason et al.   TRENDS IN CELL BIOLOGY

Capturing Changes in the Brain Microenvironment during Initial Steps of Breast Cancer Brain Metastasis

(2010) Mihaela Lorger et al.   AMERICAN JOURNAL OF PATHOLOGY

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Cancer Dissemination—Lessons from Leukocytes

(2010) Chris D. Madsen et al.   DEVELOPMENTAL CELL

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion

(2010) V. Gocheva et al.   GENES & DEVELOPMENT

Emerging principles in protease-based drug discovery

(2010) Marcin Drag et al.   NATURE REVIEWS DRUG DISCOVERY

Improvement of cathepsin S detection using a designed FRET peptide based on putative natural substrates

(2010) Marcela Oliveira et al.   PEPTIDES

Gene Expression Analysis of Macrophages That Facilitate Tumor Invasion Supports a Role for Wnt-Signaling in Mediating Their Activity in Primary Mammary Tumors

(2009) L. S. Ojalvo et al.   JOURNAL OF IMMUNOLOGY

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting

(2009) Georgina S. Butler et al.   NATURE REVIEWS DRUG DISCOVERY

Cysteine cathepsin S as an immunomodulatory target: present and future trends

(2008) Suman Gupta et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

(2008) Ferdia A. Gallagher et al.   NATURE

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE

Cysteine cathepsin proteases as pharmacological targets in cancer

(2007) Carmela Palermo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES