Ubiquitylation of nuclear receptors: new linkages and therapeutic implications
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Ubiquitylation of nuclear receptors: new linkages and therapeutic implications
Authors
Keywords
-
Journal
JOURNAL OF MOLECULAR ENDOCRINOLOGY
Volume 54, Issue 3, Pages R151-R167
Publisher
Bioscientifica
Online
2015-05-06
DOI
10.1530/jme-14-0308
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Ubiquitylation, neddylation and the DNA damage response
- (2015) J. S. Brown et al. Open Biology
- Nuclear Receptors, RXR, and the Big Bang
- (2014) Ronald M. Evans et al. CELL
- New insights into ubiquitin E3 ligase mechanism
- (2014) Christopher E Berndsen et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs
- (2014) Philip P Chamberlain et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor α and modulates estrogen-stimulated breast cancer cell proliferation
- (2014) J Zhu et al. ONCOGENE
- Lysosomal Function Is Involved in 17β-Estradiol-Induced Estrogen Receptor α Degradation and Cell Proliferation
- (2014) Pierangela Totta et al. PLoS One
- Peptide and small molecule inhibitors of HECT-type ubiquitin ligases
- (2014) Thomas Mund et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The E3 Ubiquitin Ligase Siah2 Contributes to Castration-Resistant Prostate Cancer by Regulation of Androgen Receptor Transcriptional Activity
- (2013) Jianfei Qi et al. CANCER CELL
- Suppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation
- (2013) J-H Kim et al. CELL DEATH AND DIFFERENTIATION
- Regulation of NF-κB by ubiquitination
- (2013) Jueqi Chen et al. CURRENT OPINION IN IMMUNOLOGY
- Inhibitors of SCF-Skp2/Cks1 E3 Ligase Block Estrogen-Induced Growth Stimulation and Degradation of Nuclear p27kip1: Therapeutic Potential for Endometrial Cancer
- (2013) Savvas C. Pavlides et al. ENDOCRINOLOGY
- Identification of an estrogen receptor non covalent ubiquitin-binding surface: role in 17 -estradiol-induced transcriptional activity
- (2013) V. Pesiri et al. JOURNAL OF CELL SCIENCE
- Regulation of DNA Damage Responses by Ubiquitin and SUMO
- (2013) Stephen P. Jackson et al. MOLECULAR CELL
- Pin1 modulates ERα levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradation
- (2013) P Rajbhandari et al. ONCOGENE
- Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains
- (2013) C. H. Emmerich et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Skp2 regulates androgen receptor through ubiquitin-mediated degradation independent of Akt/mTOR pathways in prostate cancer
- (2013) Bo Li et al. PROSTATE
- The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
- (2013) G. Lu et al. SCIENCE
- Specificity in the actions of the UBR1 ubiquitin ligase in the degradation of nuclear receptors
- (2013) Rasheda Sultana et al. FEBS Open Bio
- Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions
- (2012) Koraljka Husnjak et al. Annual Review of Biochemistry
- Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains
- (2012) Mark S. Searle et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Estrogen receptor α is a novel target of the Von Hippel-Lindau protein and is responsible for the proliferation of VHL-deficient cells under hypoxic conditions
- (2012) Youn-Sang Jung et al. CELL CYCLE
- The Ubiquitin Ligase Siah2 Regulates PPARγ Activity in Adipocytes
- (2012) Gail Kilroy et al. ENDOCRINOLOGY
- FBXW7 regulates glucocorticoid response in T-cell acute lymphoblastic leukaemia by targeting the glucocorticoid receptor for degradation
- (2012) A Malyukova et al. LEUKEMIA
- Beyond the Ligand-Binding Pocket: Targeting Alternate Sites in Nuclear Receptors
- (2012) Laura Caboni et al. MEDICINAL RESEARCH REVIEWS
- Phosphorylation by p38 Mitogen-Activated Protein Kinase Promotes Estrogen Receptor Turnover and Functional Activity via the SCFSkp2 Proteasomal Complex
- (2012) S. Bhatt et al. MOLECULAR AND CELLULAR BIOLOGY
- Role of SUMOylation in Full Antiestrogenicity
- (2012) K. Hilmi et al. MOLECULAR AND CELLULAR BIOLOGY
- Ligand Binding Promotes CDK-Dependent Phosphorylation of ER-Alpha on Hinge Serine 294 but Inhibits Ligand-Independent Phosphorylation of Serine 305
- (2012) J. M. Held et al. MOLECULAR CANCER RESEARCH
- ERα Phosphorylation at Y537 by Src Triggers E6-AP-ERα Binding, ERα Ubiquitylation, Promoter Occupancy, and Target Gene Expression
- (2012) Jun Sun et al. MOLECULAR ENDOCRINOLOGY
- Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages
- (2012) Yogesh Kulathu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Coordinate regulation of estrogen receptor β degradation by Mdm2 and CREB-binding protein in response to growth signals
- (2012) M Sanchez et al. ONCOGENE
- Estrogen and Progesterone Regulate p27kip1 Levels via the Ubiquitin-Proteasome System: Pathogenic and Therapeutic Implications for Endometrial Cancer
- (2012) Kuang-Tzu Huang et al. PLoS One
- Systemic Perturbation of the ERK Signaling Pathway by the Proteasome Inhibitor, MG132
- (2012) Murat Cirit et al. PLoS One
- BRCA1 Counteracts Progesterone Action by Ubiquitination Leading to Progesterone Receptor Degradation and Epigenetic Silencing of Target Promoters
- (2011) V. Calvo et al. CANCER RESEARCH
- Estrogen-Dependent Gene Transcription in Human Breast Cancer Cells Relies upon Proteasome-Dependent Monoubiquitination of Histone H2B
- (2011) T. Prenzel et al. CANCER RESEARCH
- Analysis of the Human Endogenous Coregulator Complexome
- (2011) Anna Malovannaya et al. CELL
- 17β-Estradiol-induced cell proliferation requires estrogen receptor (ER) α monoubiquitination
- (2011) Piergiorgio La Rosa et al. CELLULAR SIGNALLING
- Cracking the Estrogen Receptor's Posttranslational Code in Breast Tumors
- (2011) Muriel Le Romancer et al. ENDOCRINE REVIEWS
- Minireview: Recent Advances in Extranuclear Steroid Receptor Actions
- (2011) Stephen R. Hammes et al. ENDOCRINOLOGY
- 17β-estradiol regulates estrogen receptor α monoubiquitination
- (2011) Piergiorgio La Rosa et al. IUBMB LIFE
- Future Directions of Next-Generation Novel Therapies, Combination Approaches, and the Development of Personalized Medicine in Myeloma
- (2011) Constantine S. Mitsiades et al. JOURNAL OF CLINICAL ONCOLOGY
- Noncanonical K27-Linked Polyubiquitination of TIEG1 Regulates Foxp3 Expression and Tumor Growth
- (2011) D.-J. Peng et al. JOURNAL OF IMMUNOLOGY
- Engineering and Structural Characterization of a Linear Polyubiquitin-Specific Antibody
- (2011) Marissa L. Matsumoto et al. JOURNAL OF MOLECULAR BIOLOGY
- Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1
- (2011) Liliane Glauser et al. JOURNAL OF NEUROCHEMISTRY
- Human Proteome-scale Structural Modeling of E2–E3 Interactions Exploiting Interface Motifs
- (2011) Gozde Kar et al. JOURNAL OF PROTEOME RESEARCH
- Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
- (2011) Woong Kim et al. MOLECULAR CELL
- SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
- (2011) Fuminori Tokunaga et al. NATURE
- SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
- (2011) Fumiyo Ikeda et al. NATURE
- Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer
- (2011) Xin Pan et al. NATURE MEDICINE
- Identification of a Lysosomal Pathway That Modulates Glucocorticoid Signaling and the Inflammatory Response
- (2011) Y. He et al. Science Signaling
- Emerging roles for Lys11-linked polyubiquitin in cellular regulation
- (2011) Anja Bremm et al. TRENDS IN BIOCHEMICAL SCIENCES
- K11-linked ubiquitin chains as novel regulators of cell division
- (2011) Katherine E. Wickliffe et al. TRENDS IN CELL BIOLOGY
- Regression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor
- (2010) Raymond J. Andersen et al. CANCER CELL
- RBCK1 Drives Breast Cancer Cell Proliferation by Promoting Transcription of Estrogen Receptor and Cyclin B1
- (2010) N. Gustafsson et al. CANCER RESEARCH
- The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer
- (2010) Donald P McDonnell et al. CURRENT OPINION IN PHARMACOLOGY
- The ubiquitous role of ubiquitin in the DNA damage response
- (2010) Abdallah Al-Hakim et al. DNA REPAIR
- The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process
- (2010) Pierre Chymkowitch et al. EMBO JOURNAL
- c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling
- (2010) Jasmin N Dynek et al. EMBO JOURNAL
- Parkin degrades estrogen-related receptors to limit the expression of monoamine oxidases
- (2010) Y. Ren et al. HUMAN MOLECULAR GENETICS
- The Machado–Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability
- (2010) Thomas M. Durcan et al. HUMAN MOLECULAR GENETICS
- Negative feedback loop of BRCA1–BARD1 ubiquitin ligase on estrogen receptor alpha stability and activity antagonized by cancer-associated isoform of BARD1
- (2010) Eva Dizin et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Contribution of Lysine 11-linked Ubiquitination to MIR2-mediated Major Histocompatibility Complex Class I Internalization
- (2010) Eiji Goto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Improved Quantitative Mass Spectrometry Methods for Characterizing Complex Ubiquitin Signals
- (2010) Lilian Phu et al. MOLECULAR & CELLULAR PROTEOMICS
- The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases
- (2010) Cheol-Sang Hwang et al. NATURE CELL BIOLOGY
- PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
- (2010) Sven Geisler et al. NATURE CELL BIOLOGY
- Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange
- (2010) Bret D Freudenthal et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Identification of a Primary Target of Thalidomide Teratogenicity
- (2010) T. Ito et al. SCIENCE
- Alternative Inhibition of Androgen Receptor Signaling: Peptidomimetic Pyrimidines As Direct Androgen Receptor/Coactivator Disruptors
- (2009) Jillian R. Gunther et al. ACS Chemical Biology
- RING Domain E3 Ubiquitin Ligases
- (2009) Raymond J. Deshaies et al. Annual Review of Biochemistry
- The emerging complexity of protein ubiquitination
- (2009) David Komander BIOCHEMICAL SOCIETY TRANSACTIONS
- Regulation of Androgen Receptor Transcriptional Activity and Specificity by RNF6-Induced Ubiquitination
- (2009) Kexin Xu et al. CANCER CELL
- Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation
- (2009) Ping Xu et al. CELL
- Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation
- (2009) Simin Rahighi et al. CELL
- The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins
- (2009) Sjoerd J. L. van Wijk et al. FASEB JOURNAL
- Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network
- (2009) G. Markson et al. GENOME RESEARCH
- HACE1: A novel repressor of RAR transcriptional activity
- (2009) Jianhua Zhao et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- A Ubiquitin Replacement Strategy in Human Cells Reveals Distinct Mechanisms of IKK Activation by TNFα and IL-1β
- (2009) Ming Xu et al. MOLECULAR CELL
- BRCA1 Regulates Acetylation and Ubiquitination of Estrogen Receptor-α
- (2009) Yongxian Ma et al. MOLECULAR ENDOCRINOLOGY
- Involvement of linear polyubiquitylation of NEMO in NF-κB activation
- (2009) Fuminori Tokunaga et al. NATURE CELL BIOLOGY
- Building ubiquitin chains: E2 enzymes at work
- (2009) Yihong Ye et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways
- (2009) Brenda A. Schulman et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Ubiquitin-binding domains — from structures to functions
- (2009) Ivan Dikic et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Breaking the chains: structure and function of the deubiquitinases
- (2009) David Komander et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Proteasome inhibition represses ERα gene expression in ER+ cells: a new link between proteasome activity and estrogen signaling in breast cancer
- (2009) G L Powers et al. ONCOGENE
- Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer
- (2009) C. Tran et al. SCIENCE
- Control of AMPK-related kinases by USP9X and atypical Lys29/Lys33-linked polyubiquitin chains
- (2008) Abdallah K. Al-Hakim et al. BIOCHEMICAL JOURNAL
- The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development
- (2008) Francesca Bernassola et al. CANCER CELL
- Regulation of Estrogen-Dependent Transcription by the LIM Cofactors CLIM and RLIM in Breast Cancer
- (2008) S. A. Johnsen et al. CANCER RESEARCH
- Ubiquitin Chain Editing Revealed by Polyubiquitin Linkage-Specific Antibodies
- (2008) Kim Newton et al. CELL
- Structural Insights into E1-Catalyzed Ubiquitin Activation and Transfer to Conjugating Enzymes
- (2008) Imsang Lee et al. CELL
- Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting Complex
- (2008) Lingyan Jin et al. CELL
- E3 ligase FLRF (Rnf41) regulates differentiation of hematopoietic progenitors by governing steady-state levels of cytokine and retinoic acid receptors
- (2008) Xin Jing et al. EXPERIMENTAL HEMATOLOGY
- A Feedback Loop between the Androgen Receptor and a NEDD4-binding Protein, PMEPA1, in Prostate Cancer Cells
- (2008) Hongyun Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A New Small Molecule Inhibitor of Estrogen Receptor α Binding to Estrogen Response Elements Blocks Estrogen-dependent Growth of Cancer Cells
- (2008) Chengjian Mao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Blocking Estrogen Signaling After the Hormone: Pyrimidine-Core Inhibitors of Estrogen Receptor-Coactivator Binding
- (2008) Alexander A. Parent et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mat1 Inhibits Peroxisome Proliferator-Activated Receptor -Mediated Adipocyte Differentiation
- (2008) K. Helenius et al. MOLECULAR AND CELLULAR BIOLOGY
- Regulation of Estrogen Rapid Signaling through Arginine Methylation by PRMT1
- (2008) Muriel Le Romancer et al. MOLECULAR CELL
- Regulation of Estrogen Receptor α by the SET7 Lysine Methyltransferase
- (2008) Krithika Subramanian et al. MOLECULAR CELL
- Phosphorylation of Activation Function-1 Regulates Proteasome-Dependent Nuclear Mobility and E6-Associated Protein Ubiquitin Ligase Recruitment to the Estrogen Receptor β
- (2007) Nathalie Picard et al. MOLECULAR ENDOCRINOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started