Beyond the Ligand-Binding Pocket: Targeting Alternate Sites in Nuclear Receptors
Published 2012 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Beyond the Ligand-Binding Pocket: Targeting Alternate Sites in Nuclear Receptors
Authors
Keywords
-
Journal
MEDICINAL RESEARCH REVIEWS
Volume 33, Issue 5, Pages 1081-1118
Publisher
Wiley
Online
2012-11-27
DOI
10.1002/med.21275
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The Function of Steroid Receptor Coactivator-1 in Normal Tissues and Cancer
- (2012) Claire A. Walsh et al. International Journal of Biological Sciences
- “True” Antiandrogens—Selective Non-Ligand-Binding Pocket Disruptors of Androgen Receptor–Coactivator Interactions: Novel Tools for Prostate Cancer
- (2012) Laura Caboni et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Evaluation of Sulfonylnitrophenylthiazoles (SNPTs) as Thyroid Hormone Receptor–Coactivator Interaction Inhibitors
- (2012) Jong Yeon Hwang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of the First Irreversible Small Molecule Inhibitors of the Interaction between the Vitamin D Receptor and Coactivators
- (2012) Premchendar Nandhikonda et al. JOURNAL OF MEDICINAL CHEMISTRY
- Allosteric Conversation in the Androgen Receptor Ligand-Binding Domain Surfaces
- (2012) Solène Grosdidier et al. MOLECULAR ENDOCRINOLOGY
- Small Molecule Inhibitors Targeting the “Achilles' Heel” of Androgen Receptor Activity: Figure 1.
- (2011) Marianne D. Sadar CANCER RESEARCH
- Discovering Small-Molecule Estrogen Receptor α/Coactivator Binding Inhibitors: High-Throughput Screening, Ligand Development, and Models for Enhanced Potency
- (2011) Aiming Sun et al. ChemMedChem
- Alternatively spliced androgen receptor variants
- (2011) Scott M Dehm et al. ENDOCRINE-RELATED CANCER
- Methylsulfonylnitrobenzoates, a New Class of Irreversible Inhibitors of the Interaction of the Thyroid Hormone Receptor and Its Obligate Coactivators That Functionally Antagonizes Thyroid Hormone
- (2011) Jong Yeon Hwang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Niphatenones, Glycerol Ethers from the Sponge Niphates digitalis Block Androgen Receptor Transcriptional Activity in Prostate Cancer Cells: Structure Elucidation, Synthesis, and Biological Activity
- (2011) Labros G. Meimetis et al. JOURNAL OF MEDICINAL CHEMISTRY
- Inhibitors of Androgen Receptor Activation Function-2 (AF2) Site Identified through Virtual Screening
- (2011) Peter Axerio-Cilies et al. JOURNAL OF MEDICINAL CHEMISTRY
- Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor through Virtual Screening.
- (2011) Nathan A. Lack et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design and Structure of Stapled Peptides Binding to Estrogen Receptors
- (2011) Chris Phillips et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Androgen receptor coregulators: Recruitment via the coactivator binding groove
- (2011) Dennis J. van de Wijngaart et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- A conserved surface on the ligand binding domain of nuclear receptors for allosteric control
- (2011) Víctor Buzón et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Small Molecule Inhibition of the Steroid Receptor Coactivators, SRC-3 and SRC-1
- (2011) Ying Wang et al. MOLECULAR ENDOCRINOLOGY
- Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells
- (2011) J. T. De Leon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators
- (2010) Yusuke Mita et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The biology of hormone refractory breast and prostate cancer: An NCI workshop report
- (2010) Suresh Mohla et al. CANCER BIOLOGY & THERAPY
- Regression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor
- (2010) Raymond J. Andersen et al. CANCER CELL
- Synthesis and Crystal Structure of a Phosphorylated Estrogen Receptor Ligand Binding Domain
- (2010) Sabine Möcklinghoff et al. CHEMBIOCHEM
- Phage display selection of miniprotein binders of the Estrogen Receptor
- (2010) Trang Phan et al. CHEMICAL COMMUNICATIONS
- Peptide Antagonist of the Androgen Receptor
- (2010) Wenqing Gao CURRENT PHARMACEUTICAL DESIGN
- A Noncompetitive Small Molecule Inhibitor of Estrogen-regulated Gene Expression and Breast Cancer Cell Growth That Enhances Proteasome-dependent Degradation of Estrogen Receptor α
- (2010) Nicole M. Kretzer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Small Molecule Inhibitors as Probes for Estrogen and Androgen Receptor Action
- (2010) David J. Shapiro et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Steroid Receptor Coactivator (SRC) Family: Masters of Systems Biology
- (2010) Brian York et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding
- (2010) David M. Chenoweth et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1–2 study
- (2010) Howard I Scher et al. LANCET
- Anacardic Acid Inhibits Estrogen Receptor -DNA Binding and Reduces Target Gene Transcription and Breast Cancer Cell Proliferation
- (2010) D. J. Schultz et al. MOLECULAR CANCER THERAPEUTICS
- Identification of Ligand-Selective Peptide Antagonists of the Mineralocorticoid Receptor Using Phage Display
- (2010) Jun Yang et al. MOLECULAR ENDOCRINOLOGY
- Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic
- (2010) G. H. Bird et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of androgen receptor functions by gelsolin FxxFF peptide delivered by transfection, cell-penetrating peptides, and lentiviral infection
- (2010) Dennis J. van de Wijngaart et al. PROSTATE
- AR Inhibitors Identified by High-Throughput Microscopy Detection of Conformational Change and Subcellular Localization
- (2009) Jeremy O. Jones et al. ACS Chemical Biology
- Alternative Inhibition of Androgen Receptor Signaling: Peptidomimetic Pyrimidines As Direct Androgen Receptor/Coactivator Disruptors
- (2009) Jillian R. Gunther et al. ACS Chemical Biology
- Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics
- (2009) Belen Vaz et al. CHEMICAL COMMUNICATIONS
- Perturbation of Estrogen Receptor α Localization with Synthetic Nona-Arginine LXXLL-Peptide Coactivator Binding Inhibitors
- (2009) Maëlle Carraz et al. CHEMISTRY & BIOLOGY
- Differential Presentation of Protein Interaction Surfaces on the Androgen Receptor Defines the Pharmacological Actions of Bound Ligands
- (2009) John David Norris et al. CHEMISTRY & BIOLOGY
- Improvement of Pharmacological Properties of Irreversible Thyroid Receptor Coactivator Binding Inhibitors
- (2009) Jong Yeon Hwang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Covalent Modifiers: An Orthogonal Approach to Drug Design
- (2009) Michele H. Potashman et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cyclic Pyrrole−Imidazole Polyamides Targeted to the Androgen Response Element
- (2009) David M. Chenoweth et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Minireview: Not Picking Pockets: Nuclear Receptor Alternate-Site Modulators (NRAMs)
- (2009) Terry W. Moore et al. MOLECULAR ENDOCRINOLOGY
- Synthesis of Biphenyl Proteomimetics as Estrogen Receptor-α Coactivator Binding Inhibitors
- (2009) Anna B. Williams et al. ORGANIC LETTERS
- Elucidating the ‘Jekyll and Hyde’ Nature of PXR: The Case for Discovering Antagonists or Allosteric Antagonists
- (2009) Arunima Biswas et al. PHARMACEUTICAL RESEARCH
- Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists
- (2009) J. D. Joseph et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Non-competitive androgen receptor inhibition in vitro and in vivo
- (2009) J. O. Jones et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer
- (2009) C. Tran et al. SCIENCE
- Amphipathic Benzenes Are Designed Inhibitors of the Estrogen Receptor α/Steroid Receptor Coactivator Interaction
- (2008) Jillian R. Gunther et al. ACS Chemical Biology
- A Cellular Conformation-Based Screen for Androgen Receptor Inhibitors
- (2008) Jeremy O. Jones et al. ACS Chemical Biology
- Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor
- (2008) Andrew L. LaFrate et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Implications of the binding of tamoxifen to the coactivator recognition site of the estrogen receptor
- (2008) D. J Kojetin et al. ENDOCRINE-RELATED CANCER
- A New Small Molecule Inhibitor of Estrogen Receptor α Binding to Estrogen Response Elements Blocks Estrogen-dependent Growth of Cancer Cells
- (2008) Chengjian Mao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Blocking Estrogen Signaling After the Hormone: Pyrimidine-Core Inhibitors of Estrogen Receptor-Coactivator Binding
- (2008) Alexander A. Parent et al. JOURNAL OF MEDICINAL CHEMISTRY
- Computational Discovery of Novel Low Micromolar Human Pregnane X Receptor Antagonists
- (2008) S. Ekins et al. MOLECULAR PHARMACOLOGY
- Sintokamides A to E, Chlorinated Peptides from the SpongeDysideasp. that Inhibit Transactivation of the N-Terminus of the Androgen Receptor in Prostate Cancer Cells
- (2008) Marianne D. Sadar et al. ORGANIC LETTERS
- The Phytoestrogen Coumestrol Is a Naturally Occurring Antagonist of the Human Pregnane X Receptor
- (2007) Hongwei Wang et al. MOLECULAR ENDOCRINOLOGY
- Molecular characterization of a B-ring unsaturated estrogen: Implications for conjugated equine estrogen components of Premarin
- (2007) Robert W. Hsieh et al. STEROIDS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now