Translational Bioinformatics: Linking the Molecular World to the Clinical World

Is gene array testing to be considered routine now?

(2011) Soonmyung Paik   BREAST

Robust Replication of Genotype-Phenotype Associations across Multiple Diseases in an Electronic Medical Record

(2010) Marylyn D. Ritchie et al.   AMERICAN JOURNAL OF HUMAN GENETICS

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations

(2010) J. C. Denny et al.   BIOINFORMATICS

Principles of Human Subjects Protections Applied in an Opt-Out, De-identified Biobank

(2010) Jill Pulley et al.   CTS-Clinical and Translational Science

Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2)

(2010) S. N. Murphy et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Challenges in the clinical application of whole-genome sequencing

(2010) Kelly E Ormond et al.   LANCET

Clinical assessment incorporating a personal genome

(2010) Euan A Ashley et al.   LANCET

A side effect resource to capture phenotypic effects of drugs

(2010) Michael Kuhn et al.   Molecular Systems Biology

An Environment-Wide Association Study (EWAS) on Type 2 Diabetes Mellitus

(2010) Chirag J. Patel et al.   PLoS One

Systematic discovery of nonobvious human disease models through orthologous phenotypes

(2010) K. L. McGary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of Genetic Inheritance in a Family Quartet by Whole-Genome Sequencing

(2010) J. C. Roach et al.   SCIENCE

Toward a complete in silico , multi-layered embryonic stem cell regulatory network

(2010) Huilei Xu et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Translational bioinformatics in the cloud: an affordable alternative

(2010) Joel T Dudley et al.   Genome Medicine

Rare Variants Create Synthetic Genome-Wide Associations

(2010) Samuel P. Dickson et al.   PLOS BIOLOGY

Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model

(2010) Roger L. Chang et al.   PLoS Computational Biology

Optimal Drug Synergy in Antimicrobial Treatments

(2010) Joseph Peter Torella et al.   PLoS Computational Biology

Network-Based Elucidation of Human Disease Similarities Reveals Common Functional Modules Enriched for Pluripotent Drug Targets

(2010) Silpa Suthram et al.   PLoS Computational Biology

Web-Based, Participant-Driven Studies Yield Novel Genetic Associations for Common Traits

(2010) Nicholas Eriksson et al.   PLoS Genetics

Do-it-yourself genetic testing

(2010) Steven L Salzberg et al.   GENOME BIOLOGY

Data recovery and integration from public databases uncovers transformation-specific transcriptional downregulation of cAMP-PKA pathway-encoding genes

(2009) Chiara Balestrieri et al.   BMC BIOINFORMATICS

Comparison of concept recognizers for building the Open Biomedical Annotator

(2009) Nigam H Shah et al.   BMC BIOINFORMATICS

Generating Genome-Scale Candidate Gene Lists for Pharmacogenomics

(2009) N T Hansen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

An agenda for personalized medicine

(2009) Pauline C. Ng et al.   NATURE

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Genome-wide identification of post-translational modulators of transcription factor activity in human B cells

(2009) Kai Wang et al.   NATURE BIOTECHNOLOGY

Exome sequencing identifies the cause of a mendelian disorder

(2009) Sarah B Ng et al.   NATURE GENETICS

Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Geographic Dependence, Surveillance, and Origins of the 2009 Influenza A (H1N1) Virus

(2009) Vladimir Trifonov et al.   NEW ENGLAND JOURNAL OF MEDICINE

Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis

(2009) Sarah L. Kinnings et al.   PLoS Computational Biology

Autoimmune Disease Classification by Inverse Association with SNP Alleles

(2009) Marina Sirota et al.   PLoS Genetics

Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions

(2009) Soumya Raychaudhuri et al.   PLoS Genetics

Prevalence in the United States of Selected Candidate Gene Variants: Third National Health and Nutrition Examination Survey, 1991-1994

(2008) M.-h. Chang et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Human genomes as email attachments

(2008) Scott Christley et al.   BIOINFORMATICS

On Jim Watson's APOE status: genetic information is hard to hide

(2008) Dale R Nyholt et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genetic-linkage mapping of complex hereditary disorders to a whole-genome molecular-interaction network

(2008) I. Iossifov et al.   GENOME RESEARCH

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE

Resolving Individuals Contributing Trace Amounts of DNA to Highly Complex Mixtures Using High-Density SNP Genotyping Microarrays

(2008) Nils Homer et al.   PLoS Genetics