Gemfibrozil Is a Strong Inactivator of CYP2C8 in Very Small Multiple Doses
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Title
Gemfibrozil Is a Strong Inactivator of CYP2C8 in Very Small Multiple Doses
Authors
Keywords
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Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 91, Issue 5, Pages 846-855
Publisher
Springer Nature
Online
2012-04-04
DOI
10.1038/clpt.2011.313
References
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Related references
Note: Only part of the references are listed.- Mechanism-Based Inactivation of CYP2C8 by Gemfibrozil Occurs Rapidly in Humans
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- Benzylic Oxidation of Gemfibrozil-1-O-β-Glucuronide by P450 2C8 Leads to Heme Alkylation and Irreversible Inhibition
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- CYP2C8 Activity Recovers within 96 Hours after Gemfibrozil Dosing: Estimation of CYP2C8 Half-Life Using Repaglinide as an in Vivo Probe
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- The Effect of Gemfibrozil on Repaglinide Pharmacokinetics Persists for at Least 12 h After the Dose: Evidence for Mechanism-based Inhibition of CYP2C8 In Vivo
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