Physiologically based mechanistic modelling to predict complex drug–drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut—The effect of diltiazem on the time-course of exposure to triazolam

Published 2009 View Full Article

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Title
Physiologically based mechanistic modelling to predict complex drug–drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut—The effect of diltiazem on the time-course of exposure to triazolam
Authors
Keywords
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Journal
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 39, Issue 5, Pages 298-309
Publisher
Elsevier BV
Online
2009-12-17
DOI
10.1016/j.ejps.2009.12.002

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