Prediction of Pharmacokinetics and Drug–Drug Interactions When Hepatic Transporters are Involved

Mechanism-Based Pharmacokinetic Modeling to Evaluate Transporter-Enzyme Interplay in Drug Interactions and Pharmacogenetics of Glyburide

(2014) Manthena V. S. Varma et al.   AAPS Journal

A “middle-out” approach to human pharmacokinetic predictions for OATP substrates using physiologically-based pharmacokinetic modeling

(2014) Rui Li et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Reduced Physiologically-Based Pharmacokinetic Model of Repaglinide: Impact of OATP1B1 and CYP2C8 Genotype and Source of In Vitro Data on the Prediction of Drug-Drug Interaction Risk

(2014) Michael Gertz et al.   PHARMACEUTICAL RESEARCH

Role of Hepatic Efflux Transporters in Regulating Systemic and Hepatocyte Exposure to Xenobiotics

(2013) Nathan D. Pfeifer et al.   Annual Review of Pharmacology and Toxicology

Quantitative assessment of the contribution of sodium-dependent taurocholate co-transporting polypeptide (NTCP) to the hepatic uptake of rosuvastatin, pitavastatin and fluvastatin

(2013) Yi-an Bi et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Disposition Pathway-Dependent Approach for Predicting Organic Anion-Transporting Polypeptide-Mediated Drug–Drug Interactions

(2013) Zhe-Yi Hu   CLINICAL PHARMACOKINETICS

A Mechanistic Framework for In Vitro–In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug–Drug Interaction Between Rosuvastatin and Cyclosporine

(2013) M. Jamei et al.   CLINICAL PHARMACOKINETICS

Towards Quantitation of the Effects of Renal Impairment and Probenecid Inhibition on Kidney Uptake and Efflux Transporters, Using Physiologically Based Pharmacokinetic Modelling and Simulations

(2013) Vicky Hsu et al.   CLINICAL PHARMACOKINETICS

Ethnic Variability in the Plasma Exposures of OATP1B1 Substrates Such as HMG-CoA Reductase Inhibitors: A Kinetic Consideration of Its Mechanism

(2013) Y Tomita et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

(2013) X Chu et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

ITC Recommendations for Transporter Kinetic Parameter Estimation and Translational Modeling of Transport-Mediated PK and DDIs in Humans

(2013) M J Zamek-Gliszczynski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Model-based approaches to predict drug–drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond

(2013) Hugh A Barton et al.   Expert Opinion on Drug Metabolism & Toxicology

Absolute measurement of species differences in sodium taurocholate cotransporting polypeptide (NTCP/Ntcp) and its modulation in cultured hepatocytes

(2013) Xi Qiu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Interindividual Variability in the Hepatic Expression of the Human Breast Cancer Resistance Protein (BCRP/ABCG2): Effect of Age, Sex, and Genotype

(2013) Bhagwat Prasad et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Application of permeability-limited physiologically-based pharmacokinetic models: Part I–digoxin pharmacokinetics incorporating P-glycoprotein-mediated efflux

(2013) Sibylle Neuhoff et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mechanistic Modeling to Predict the Transporter- and Enzyme-Mediated Drug-Drug Interactions of Repaglinide

(2013) Manthena V. S. Varma et al.   PHARMACEUTICAL RESEARCH

Dissecting the relative contribution of OATP1B1-mediated uptake of xenobiotics into human hepatocytes using siRNA

(2013) B. Williamson et al.   XENOBIOTICA

Hepatic and Intestinal Drug Transporters: Prediction of Pharmacokinetic Effects Caused by Drug-Drug Interactions and Genetic Polymorphisms

(2012) Kenta Yoshida et al.   Annual Review of Pharmacology and Toxicology

Predicting human hepatic clearance from in vitro drug metabolism and transport data: a scientific and pharmaceutical perspective for assessing drug-drug interactions

(2012) Gian Camenisch et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption

(2012) Yoshihisa Shitara et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Transporter-Mediated Drug–Drug Interactions Involving OATP Substrates: Predictions Based on In Vitro Inhibition Studies

(2012) K Yoshida et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A Perspective on Efflux Transport Proteins in the Liver

(2012) K Köck et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Why We Need Proper PBPK Models to Examine Intestine and Liver Oral Drug Absorption

(2012) Edwin C.Y. Chow et al.   CURRENT DRUG METABOLISM

Impact of Genetic Variation in OATP Transporters to Drug Disposition and Response

(2012) Inna Y. Gong et al.   Drug Metabolism and Pharmacokinetics

Impact of drug transporter pharmacogenomics on pharmacokinetic and pharmacodynamic variability – considerations for drug development

(2012) Yurong Lai et al.   Expert Opinion on Drug Metabolism & Toxicology

Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug–Drug Interactions

(2012) Maria Karlgren et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of Organic Anion Transporting Polypeptide (OATP) Expression and Its Functional Contribution to the Uptake of Substrates in Human Hepatocytes

(2012) Emi Kimoto et al.   MOLECULAR PHARMACEUTICS

Physiologically Based Modeling of Pravastatin Transporter-Mediated Hepatobiliary Disposition and Drug-Drug Interactions

(2012) Manthena V. S. Varma et al.   PHARMACEUTICAL RESEARCH

Cyclosporine Inhibition of Hepatic and Intestinal CYP3A4, Uptake and Efflux Transporters: Application of PBPK Modeling in the Assessment of Drug-Drug Interaction Potential

(2012) Michael Gertz et al.   PHARMACEUTICAL RESEARCH

Oral drug delivery utilizing intestinal OATP transporters

(2011) Ikumi Tamai   ADVANCED DRUG DELIVERY REVIEWS

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

(2011) Malcolm Rowland et al.   Annual Review of Pharmacology and Toxicology

Pharmacokinetics of Voriconazole Administered Concomitantly with Fluconazole and Population-Based Simulation for Sequential Use

(2011) Bharat Damle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Approaches for predicting human pharmacokinetics using interspecies pharmacokinetic scaling

(2011) Hee Eun Kang et al.   ARCHIVES OF PHARMACAL RESEARCH

Simulation of Human Intravenous and Oral Pharmacokinetics of 21 Diverse Compounds Using Physiologically Based Pharmacokinetic Modelling

(2011) Hannah M. Jones et al.   CLINICAL PHARMACOKINETICS

Identification of the Rate-Determining Process in the Hepatic Clearance of Atorvastatin in a Clinical Cassette Microdosing Study

(2011) K Maeda et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Targeting Intestinal Transporters for Optimizing Oral Drug Absorption

(2011) Manthena V. Varma et al.   CURRENT DRUG METABOLISM

Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments

(2011) T. Watanabe et al.   DRUG METABOLISM AND DISPOSITION

pH-Sensitive Interaction of HMG-CoA Reductase Inhibitors (Statins) with Organic Anion Transporting Polypeptide 2B1

(2011) Manthena V. Varma et al.   MOLECULAR PHARMACEUTICS

In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug–Drug Interactions

(2011) Maria Karlgren et al.   PHARMACEUTICAL RESEARCH

Organic Anion Transporting Polypeptide 1B1: a Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake

(2011) M. Niemi et al.   PHARMACOLOGICAL REVIEWS

The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance

(2011) Katherine S. Fenner et al.   XENOBIOTICA

Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: comparison of dynamic and static models

(2010) Eleanor J. Guest et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cyclosporine A, but Not Tacrolimus, Shows Relevant Inhibition of Organic Anion-Transporting Protein 1B1-Mediated Transport of Atorvastatin

(2010) R. Amundsen et al.   DRUG METABOLISM AND DISPOSITION

Hepatitis C Virus-related Cirrhosis is a Major Determinant of the Expression Levels of Hepatic Drug Transporters

(2010) Ken Ogasawara et al.   Drug Metabolism and Pharmacokinetics

Hepatic OATP and OCT uptake transporters: their role for drug-drug interactions and pharmacogenetic aspects

(2010) Christina Fahrmayr et al.   DRUG METABOLISM REVIEWS

Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans

(2010) Takao Watanabe et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Physiological Modeling to Understand the Impact of Enzymes and Transporters on Drug and Metabolite Data and Bioavailability Estimates

(2010) Huadong Sun et al.   PHARMACEUTICAL RESEARCH

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

(2010) C. D. Klaassen et al.   PHARMACOLOGICAL REVIEWS

Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters

(2009) Simone Leuthold et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Impact of OATP transporters on pharmacokinetics

(2009) A Kalliokoski et al.   BRITISH JOURNAL OF PHARMACOLOGY

Investigation of the Rate-Determining Process in the Hepatic Elimination of HMG-CoA Reductase Inhibitors in Rats and Humans

(2009) T. Watanabe et al.   DRUG METABOLISM AND DISPOSITION

Comparison of Different Algorithms for Predicting Clinical Drug-Drug Interactions, Based on the Use of CYP3A4 in Vitro Data: Predictions of Compounds as Precipitants of Interaction

(2009) O. A. Fahmi et al.   DRUG METABOLISM AND DISPOSITION

The Simcyp®Population-based ADME Simulator

(2009) Masoud Jamei et al.   Expert Opinion on Drug Metabolism & Toxicology

Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs

(2009) Ichiro Ieiri et al.   Expert Opinion on Drug Metabolism & Toxicology

Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data

(2009) Agnès Poirier et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Mechanistic Modeling of Hepatic Transport from Cells to Whole Body: Application to Napsagatran and Fexofenadine

(2009) Agnès Poirier et al.   MOLECULAR PHARMACEUTICS

Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Method for predicting the risk of drug–drug interactions involving inhibition of intestinal CYP3A4 and P-glycoprotein

(2009) T. Tachibana et al.   XENOBIOTICA

Presentation of a modified dispersion model (MDM) for hepatic drug extraction and a new methodology for the prediction of the rate-limiting step in hepatic metabolic clearance

(2009) U. Fagerholm   XENOBIOTICA

Effects of Gemfibrozil and Atorvastatin on the Pharmacokinetics of Repaglinide in Relation to SLCO1B1 Polymorphism

(2008) A Kalliokoski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Elucidating Rifampin's Inducing and Inhibiting Effects on Glyburide Pharmacokinetics and Blood Glucose in Healthy Volunteers: Unmasking the Differential Effects of Enzyme Induction and Transporter Inhibition for a Drug and Its Primary Metabolite

(2008) HX Zheng et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A Combined Model for Predicting CYP3A4 Clinical Net Drug-Drug Interaction Based on CYP3A4 Inhibition, Inactivation, and Induction Determined in Vitro

(2008) O. A. Fahmi et al.   DRUG METABOLISM AND DISPOSITION

Relationship between Drug/Metabolite Exposure and Impairment of Excretory Transport Function

(2008) M. J. Zamek-Gliszczynski et al.   DRUG METABOLISM AND DISPOSITION

Involvement of Multiple Transporters in the Hepatobiliary Transport of Rosuvastatin

(2008) S. Kitamura et al.   DRUG METABOLISM AND DISPOSITION

Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans

(2008) T. Watanabe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Drug-Metabolizing Enzyme and Transporter Expression in a Mouse Model of Diabetes and Obesity

(2008) Qiuqiong Cheng et al.   MOLECULAR PHARMACEUTICS

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

(2008) Paul D. Dobson et al.   NATURE REVIEWS DRUG DISCOVERY

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

The Quantitative Prediction of CYP-mediated Drug Interaction by Physiologically Based Pharmacokinetic Modeling

(2008) Motohiro Kato et al.   PHARMACEUTICAL RESEARCH

Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family

(2008) B. Hagenbuch et al.   XENOBIOTICA