A “middle-out” approach to human pharmacokinetic predictions for OATP substrates using physiologically-based pharmacokinetic modeling
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Title
A “middle-out” approach to human pharmacokinetic predictions for OATP substrates using physiologically-based pharmacokinetic modeling
Authors
Keywords
PBPK, OATP, Scaling factor, Global optimization, Sandwich cultured human hepatocytes, Middle-out
Journal
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
Volume 41, Issue 3, Pages 197-209
Publisher
Springer Nature
Online
2014-04-10
DOI
10.1007/s10928-014-9357-1
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