Biology-Oriented Synthesis of a Withanolide-Inspired Compound Collection Reveals Novel Modulators of Hedgehog Signaling

Biology-Oriented Synthesis: Harnessing the Power of Evolution

(2014) Hilde van Hattum et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

(2013) Daniel Nedelcu et al.   Nature Chemical Biology

A withanolide coagulin-L inhibits adipogenesis modulating Wnt/β-catenin pathway and cell cycle in mitotic clonal expansion

(2013) Muheeb Beg et al.   PHYTOMEDICINE

Synthesis and antitumor activity of des-AB analogue of steroidal saponin OSW-1

(2013) Daishiro Minato et al.   TETRAHEDRON

Withanolide A: synthesis and structural requirements for neurite outgrowth

(2013) Raphael Liffert et al.   Chemical Science

Potent small molecule Hedgehog agonists induce VEGF expression in vitro

(2012) Katrin Seifert et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular Pathways: The Hedgehog Signaling Pathway in Cancer

(2012) R. McMillan et al.   CLINICAL CANCER RESEARCH

Hedgehog pathway inhibition and the race against tumor evolution

(2012) Scott X. Atwood et al.   JOURNAL OF CELL BIOLOGY

Charting, Navigating, and Populating Natural Product Chemical Space for Drug Discovery

(2012) Hugo Lachance et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel withanolides target medullary thyroid cancer through inhibition of both RET phosphorylation and the mammalian target of rapamycin pathway

(2012) Abbas K. Samadi et al.   SURGERY

Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies

(2012) Chris Dockendorff et al.   ACS Medicinal Chemistry Letters

Biology-Oriented Synthesis

(2011) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural withanolides: an overview

(2011) Li-Xia Chen et al.   NATURAL PRODUCT REPORTS

A Novel Synthetic Smoothened Antagonist Transiently Inhibits Pancreatic Adenocarcinoma Xenografts in a Mouse Model

(2011) Martin F. Strand et al.   PLoS One

Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway

(2011) S. Basu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioactivity-Guided Navigation of Chemical Space

(2010) Robin S. Bon et al.   ACCOUNTS OF CHEMICAL RESEARCH

Natural Products as Chemical Probes

(2010) Erin E. Carlson   ACS Chemical Biology

A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones

(2010) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Natural Product Inspired Compound Collections

(2009) Kamal Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway

(2009) Anita Büttner et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Advances in Solution- and Solid-Phase Synthesis toward the Generation of Natural Product-like Libraries

(2009) Jyoti P. Nandy et al.   CHEMICAL REVIEWS

Natural product scaffolds as leads to drugs

(2009) David J Newman et al.   Future Medicinal Chemistry

Bioactivity-guided mapping and navigation of chemical space

(2009) Steffen Renner et al.   Nature Chemical Biology

Interactive exploration of chemical space with Scaffold Hunter

(2009) Stefan Wetzel et al.   Nature Chemical Biology

Synthesis of Sominone and Its Derivatives Based on an RCM Strategy: Discovery of A Novel Anti-Alzheimer’s Disease Medicine Candidate “Denosomin”

(2009) Yuji Matsuya et al.   ORGANIC LETTERS

Steroids and Flavonoids fromPhysalis alkekengivar.franchetiiand Their Inhibitory Effects on Nitric Oxide Production

(2008) Li Qiu et al.   JOURNAL OF NATURAL PRODUCTS

Natural products to drugs: natural product-derived compounds in clinical trials

(2008) Mark S. Butler   NATURAL PRODUCT REPORTS