A Novel Synthetic Smoothened Antagonist Transiently Inhibits Pancreatic Adenocarcinoma Xenografts in a Mouse Model
Published 2011 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A Novel Synthetic Smoothened Antagonist Transiently Inhibits Pancreatic Adenocarcinoma Xenografts in a Mouse Model
Authors
Keywords
-
Journal
PLoS One
Volume 6, Issue 6, Pages e19904
Publisher
Public Library of Science (PLoS)
Online
2011-06-18
DOI
10.1371/journal.pone.0019904
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance
- (2010) Gerrit J. P. Dijkgraaf et al. CANCER RESEARCH
- Overexpression of Smoothened Activates the Sonic Hedgehog Signaling Pathway in Pancreatic Cancer-Associated Fibroblasts
- (2010) K. Walter et al. CLINICAL CANCER RESEARCH
- Novel investigational drugs for basal cell carcinoma
- (2010) Po-Lin So et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- The perennial organelle: assembly and disassembly of the primary cilium
- (2010) E. S. Seeley et al. JOURNAL OF CELL SCIENCE
- Clinical Experience With Hedgehog Pathway Inhibitors
- (2010) Jennifer A. Low et al. JOURNAL OF CLINICAL ONCOLOGY
- GDC-0449—A potent inhibitor of the hedgehog pathway
- (2009) Kirk D. Robarge et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Tail Wags Dog: Primary Cilia and Tumorigenesis
- (2009) Monique T. Barakat et al. CANCER CELL
- Paracrine Hedgehog Signaling in Cancer
- (2009) J.-W. Theunissen et al. CANCER RESEARCH
- Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma
- (2009) Jennifer L. Dembinski et al. CLINICAL & EXPERIMENTAL METASTASIS
- GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
- (2009) O. Nolan-Stevaux et al. GENES & DEVELOPMENT
- Integrative genomic analyses on GLI1: Positive regulation of GLI1 by Hedgehog-GLI, TGFβ-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals
- (2009) Katoh INTERNATIONAL JOURNAL OF ONCOLOGY
- Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)
- (2009) Martin R. Tremblay et al. JOURNAL OF MEDICINAL CHEMISTRY
- Two sides to cilia in cancer
- (2009) Rune Toftgård NATURE MEDICINE
- Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis
- (2009) Sunny Y Wong et al. NATURE MEDICINE
- Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449
- (2009) Charles M. Rudin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
- (2009) Daniel D. Von Hoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer
- (2009) J M Bailey et al. ONCOGENE
- Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium
- (2009) Christopher W. Wilson et al. PLoS One
- Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
- (2009) J. M. Hyman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
- (2009) H. Tian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Disrupting Hedgehog May Reverse Advanced Cancer, If Only Temporarily
- (2009) S. Kean SCIENCE
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
- (2009) K. P. Olive et al. SCIENCE
- Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
- (2009) Suzie J. Scales et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Therapeutic Inhibition of Hedgehog-GLI Signaling in Cancer: Epithelial, Stromal, or Stem Cell Targets?
- (2008) Ariel Ruiz i Altaba CANCER CELL
- Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer
- (2008) J. M. Bailey et al. CLINICAL CANCER RESEARCH
- Hedgehog Signaling in Development and Cancer
- (2008) Jin Jiang et al. DEVELOPMENTAL CELL
- A paracrine requirement for hedgehog signalling in cancer
- (2008) Robert L. Yauch et al. NATURE
- Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells
- (2008) Young-Goo Han et al. NATURE NEUROSCIENCE
- Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin–proteasome pathway
- (2008) S Yue et al. ONCOGENE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search