Impact of suppressing retinoic acid-related orphan receptor gammat(ROR)γt in ameliorating central nervous system autoimmunity

Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms

(2014) Sheng Xiao et al.   IMMUNITY

T-bet is essential for Th1-mediated, but not Th17-mediated, CNS autoimmune disease

(2013) Richard A. O'Connor et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Highly polarized Th17 cells induce EAE via a T-bet independent mechanism

(2013) Heather M. Grifka-Walk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cutting Edge: The Pathogenicity of IFN- -Producing Th17 Cells Is Independent of T-bet

(2013) R. Duhen et al.   JOURNAL OF IMMUNOLOGY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Current progress of siRNA/shRNA therapeutics in clinical trials

(2011) John C. Burnett et al.   Biotechnology Journal

Early Th1 Cell Differentiation Is Marked by a Tfh Cell-like Transition

(2011) Shingo Nakayamada et al.   IMMUNITY

The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns

(2011) Kenneth J. Oestreich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

(2011) Laura A. Solt et al.   NATURE

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Current prospects for RNA interference-based therapies

(2011) Beverly L. Davidson et al.   NATURE REVIEWS GENETICS

Th1 versus Th17: Are T cell cytokines relevant in multiple sclerosis?

(2010) Amy E. Lovett-Racke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

T-bet is essential for encephalitogenicity of both Th1 and Th17 cells

(2009) Yuhong Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation

(2009) Jyoti Das et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

Foxp3 Inhibits RORγt-mediatedIL-17AmRNA Transcription through Direct Interaction with RORγt

(2008) Kenji Ichiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY