Regulatory T Cells in HIV Infection: Can Immunotherapy Regulate the Regulator?

Inhibition of Viral Replication Downregulates CD4+CD25high Regulatory T Cells and Programmed Death-Ligand 1 in Chronic Hepatitis B

(2018) Xue-Ping Nan et al.   VIRAL IMMUNOLOGY

IL-17 and Therapeutic Kynurenines in Pathogenic Inflammation to Fungi

(2014) L. Romani et al.   JOURNAL OF IMMUNOLOGY

ICOS Controls the Pool Size of Effector-Memory and Regulatory T Cells

(2014) Y. Burmeister et al.   JOURNAL OF IMMUNOLOGY

Effects of Recombinant Human Interleukin 7 on T-Cell Recovery and Thymic Output in HIV-Infected Patients Receiving Antiretroviral Therapy: Results of a Phase I/IIa Randomized, Placebo-Controlled, Multicenter Study

(2012) Y. Lévy et al.   CLINICAL INFECTIOUS DISEASES

Severe Immune Dysregulation Affects CD4+CD25hiFoxP3+ Regulatory T Cells in HIV-Infected Patients With Low-level CD4 T-Cell Repopulation Despite Suppressive Highly Active Antiretroviral Therapy

(2012) Gema Méndez-Lagares et al.   JOURNAL OF INFECTIOUS DISEASES

Preserved Function of Regulatory T Cells in Chronic HIV-1 Infection Despite Decreased Numbers in Blood and Tissue

(2012) Mathieu Angin et al.   JOURNAL OF INFECTIOUS DISEASES

Live-Attenuated Lentivirus Immunization Modulates Innate Immunity and Inflammation while Protecting Rhesus Macaques from Vaginal Simian Immunodeficiency Virus Challenge

(2012) M. Genesca et al.   JOURNAL OF VIROLOGY

Homeostasis and Function of Regulatory T Cells in HIV/SIV Infection

(2012) M. E. Moreno-Fernandez et al.   JOURNAL OF VIROLOGY

Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection

(2012) J Loebbermann et al.   Mucosal Immunology

HIV-Induced T-Cell Activation/Exhaustion in Rectal Mucosa Is Controlled Only Partially by Antiretroviral Treatment

(2012) Cesar Mauricio Rueda et al.   PLoS One

Sigmoid Th17 populations, the HIV latent reservoir, and microbial translocation in men on long-term antiretroviral therapy

(2011) Duncan Chege et al.   AIDS

IFN-  and indoleamine 2,3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity

(2011) Y. Lu et al.   BLOOD

Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanism

(2011) M. E. Moreno-Fernandez et al.   BLOOD

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

CD4+CD25lowGITR+ cells: A novel human CD4+ T-cell population with regulatory activity

(2011) Rodolfo Bianchini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells

(2011) Guoyan Cheng et al.   IMMUNOLOGICAL REVIEWS

T regulatory cells participate in the control of germinal centre reactions

(2011) Carla-Maria Alexander et al.   IMMUNOLOGY

Low Level of Regulatory T Cells and Maintenance of Balance Between Regulatory T Cells and TH17 Cells in HIV-1–Infected Elite Controllers

(2011) Lea Brandt et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Expression of CD4+ forkhead box P3 (FOXP3)+ regulatory T cells in inflammatory bowel disease

(2011) Yi WANG et al.   Journal of Digestive Diseases

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fatal Pancreatitis in Simian Immunodeficiency Virus SIVmac251-Infected Macaques Treated with 2',3'-Dideoxyinosine and Stavudine following Cytotoxic-T-Lymphocyte-Associated Antigen 4 and Indoleamine 2,3-Dioxygenase Blockade

(2011) M. Vaccari et al.   JOURNAL OF VIROLOGY

Increased Frequency of Regulatory T Cells Accompanies Increased Immune Activation in Rectal Mucosae of HIV-Positive Noncontrollers

(2011) J. M. Shaw et al.   JOURNAL OF VIROLOGY

Response to self antigen imprints regulatory memory in tissues

(2011) Michael D. Rosenblum et al.   NATURE

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

(2011) Wei Liao et al.   NATURE IMMUNOLOGY

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

Protective HIV-specific CD8+ T cells evade Treg cell suppression

(2011) Shokrollah Elahi et al.   NATURE MEDICINE

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

The Yin and Yang of Interleukin-2–Mediated Immunotherapy

(2011) Jeffrey A. Bluestone   NEW ENGLAND JOURNAL OF MEDICINE

Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis

(2011) David Saadoun et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Low T Regulatory Cell Response May Contribute to Both Viral Control and Generalized Immune Activation in HIV Controllers

(2011) Peter W. Hunt et al.   PLoS One

T Regulatory Cells Are Markers of Disease Activity in Multiple Sclerosis Patients

(2011) Dacia Dalla Libera et al.   PLoS One

The Indoleamine-2,3-Dioxygenase (IDO) Inhibitor 1-Methyl-D-tryptophan Upregulates IDO1 in Human Cancer Cells

(2011) Christiane A. Opitz et al.   PLoS One

Frequency of Circulating Regulatory T Cells Increases during Chronic HIV Infection and Is Largely Controlled by Highly Active Antiretroviral Therapy

(2011) Pietro Presicce et al.   PLoS One

The PDL1-PD1 Axis Converts Human TH1 Cells into Regulatory T Cells

(2011) S. Amarnath et al.   Science Translational Medicine

Challenges in dendritic cells-based therapeutic vaccination in HIV-1 infection

(2011) Felipe García et al.   VACCINE

Analysis of CD4+CD25+Foxp3+ Regulatory T Cells in HIV-Exposed Seronegative Persons and HIV-Infected Persons with Different Disease Progressions

(2011) Lin Li et al.   VIRAL IMMUNOLOGY

CD39/Adenosine Pathway Is Involved in AIDS Progression

(2011) Maria Nikolova et al.   PLoS Pathogens

IL-7 and lymphopenia

(2010) Frederique Ponchel et al.   CLINICA CHIMICA ACTA

PD-1 modulates regulatory T cells and suppresses T-cell responses in HCV-associated lymphoma

(2010) Lei Ni et al.   IMMUNOLOGY AND CELL BIOLOGY

Regulatory T cells as potential targets for immunotherapy in inflammatory bowel disease

(2010) Caterina Strisciuglio et al.   Immunotherapy

A critical role for regulatory T cell–mediated control of inflammation in the absence of commensal microbiota

(2010) Takatoshi Chinen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-17- and IFN- -Secreting Foxp3+ T Cells Infiltrate the Target Tissue in Experimental Autoimmunity

(2010) M. Esposito et al.   JOURNAL OF IMMUNOLOGY

Reciprocal granzyme/perforin-mediated death of human regulatory and responder T cells is regulated by interleukin-2 (IL-2)

(2010) Malgorzata Czystowska et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Comprehensive Analysis of Frequency and Phenotype of T Regulatory Cells in HIV Infection: CD39 Expression of FoxP3+ T Regulatory Cells Correlates with Progressive Disease

(2010) J. Schulze zur Wiesch et al.   JOURNAL OF VIROLOGY

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

(2010) Elias A Said et al.   NATURE MEDICINE

Relationship between Regulatory T Cells and Immune Activation in Human Immunodeficiency Virus-Infected Patients Interrupting Antiretroviral Therapy

(2010) Laurence Weiss et al.   PLoS One

In vivo expansion of naive and activated CD4+CD25+FOXP3+ regulatory T cell populations in interleukin-2-treated HIV patients

(2010) L. Weiss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

(2010) M. A. Curran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Kinase C-  Mediates Negative Feedback on Regulatory T Cell Function

(2010) A. Zanin-Zhorov et al.   SCIENCE

Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of TH17 to Regulatory T Cells in HIV Disease

(2010) D. Favre et al.   Science Translational Medicine

Th17 and regulatory T cells: implications for AIDS pathogenesis

(2010) Bittoo Kanwar et al.   Current Opinion in HIV and AIDS

Th17 lineage commitment and HIV-1 pathogenesis

(2010) Petronela Ancuta et al.   Current Opinion in HIV and AIDS

Regulatory T Cells and Human Myeloid Dendritic Cells Promote Tolerance via Programmed Death Ligand-1

(2010) Shoba Amarnath et al.   PLOS BIOLOGY

Regulatory T cells in HIV infection: pathogenic or protective participants in the immune response?

(2009) Barbara Fazekas de St Groth et al.   AIDS

Limited efficiency of endogenous interleukin-7 levels in T cell reconstitution during HIV-1 infection: will exogenous interleukin-7 therapy work?

(2009) Bence Rethi et al.   AIDS

Injection of glycosylated recombinant simian IL-7 provokes rapid and massive T-cell homing in rhesus macaques

(2009) S. Beq et al.   BLOOD

Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes

(2009) M. D. Sharma et al.   BLOOD

Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy

(2009) Jean-Pierre Routy et al.   CLINICAL IMMUNOLOGY

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

(2009) Maria A. Curotto de Lafaille et al.   IMMUNITY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Enhanced T cell recovery in HIV-1–infected adults through IL-7 treatment

(2009) Yves Levy et al.   JOURNAL OF CLINICAL INVESTIGATION

PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV

(2009) Debora Franceschini et al.   JOURNAL OF CLINICAL INVESTIGATION

A2A Adenosine Receptor May Allow Expansion of T Cells Lacking Effector Functions in Extracellular Adenosine-Rich Microenvironments

(2009) A. Ohta et al.   JOURNAL OF IMMUNOLOGY

Combined Effect of Antiretroviral Therapy and Blockade of IDO in SIV-Infected Rhesus Macaques

(2009) A. Boasso et al.   JOURNAL OF IMMUNOLOGY

IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

(2009) B. Baban et al.   JOURNAL OF IMMUNOLOGY

Decreased Immune Activation in Resistance to HIV‐1 Infection Is Associated with an Elevated Frequency of CD4+CD25+FOXP3+Regulatory T Cells

(2009) Catherine M. Card et al.   JOURNAL OF INFECTIOUS DISEASES

Interleukin-2 Therapy in Patients with HIV Infection

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection

(2009) David Favre et al.   PLoS Pathogens

HIV-specific regulatory T cells are associated with higher CD4 cell counts in primary infection

(2008) Hassen Kared et al.   AIDS

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections

(2008) J. M. Brenchley et al.   BLOOD

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Regulatory T cells in health and disease

(2008) Ciriaco A. Piccirillo   CYTOKINE

High frequency and proliferation of CD4+FOXP3+ Treg in HIV-1-infected patients with low CD4 counts

(2008) Xiuqiong Bi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α

(2008) Jeremy Ben-Shoshan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

CD4+CD25+ regulatory T cells in the small intestinal lamina propria show an effector/memory phenotype

(2008) Z. Guo et al.   INTERNATIONAL IMMUNOLOGY

Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host

(2008) T ZELANTE et al.   MICROBES AND INFECTION

Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses

(2008) M Macal et al.   Mucosal Immunology

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

(2008) Luigina Romani et al.   NATURE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE

The Biology of Interleukin-2

(2007) Thomas R. Malek   Annual Review of Immunology