Homeostasis and Function of Regulatory T Cells in HIV/SIV Infection

Cutting Edge: Experimentally Induced Immune Activation in Natural Hosts of Simian Immunodeficiency Virus Induces Significant Increases in Viral Replication and CD4+ T Cell Depletion

(2014) I. Pandrea et al.   JOURNAL OF IMMUNOLOGY

Immune Activation Driven by CTLA-4 Blockade Augments Viral Replication at Mucosal Sites in Simian Immunodeficiency Virus Infection

(2014) V. Cecchinato et al.   JOURNAL OF IMMUNOLOGY

CD127 and CD25 Expression Defines CD4+ T Cell Subsets That Are Differentially Depleted during HIV Infection

(2014) R. M. Dunham et al.   JOURNAL OF IMMUNOLOGY

Human CD4+CD25+Foxp3+ Regulatory T Cells Do Not Constitutively Express IL-35

(2014) E. Bardel et al.   JOURNAL OF IMMUNOLOGY

Chemokine and Cytokine Mediated Loss of Regulatory T Cells in Lymph Nodes during Pathogenic Simian Immunodeficiency Virus Infection

(2014) S. Qin et al.   JOURNAL OF IMMUNOLOGY

Preserved Function of Regulatory T Cells in Chronic HIV-1 Infection Despite Decreased Numbers in Blood and Tissue

(2012) Mathieu Angin et al.   JOURNAL OF INFECTIOUS DISEASES

Myeloid dendritic cells isolated from tissues of SIV-infected Rhesus macaques promote the induction of regulatory T cells

(2011) Pietro Presicce et al.   AIDS

cAMP During HIV Infection: Friend or Foe?

(2011) Maria E. Moreno-Fernandez et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Human FoxP3+ regulatory T cells in systemic autoimmune diseases

(2011) Makoto Miyara et al.   AUTOIMMUNITY REVIEWS

Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanism

(2011) M. E. Moreno-Fernandez et al.   BLOOD

Elevated effector cell sensitivity to Treg-cell suppression that is not associated with reduced Th17-cell expression distinguishes HIV+asymptomatic subjects from progressors

(2011) Georgina S. Thorborn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cutting Edge: Human Regulatory T Cells Require IL-35 To Mediate Suppression and Infectious Tolerance

(2011) V. Chaturvedi et al.   JOURNAL OF IMMUNOLOGY

CD4+FOXP3+ T Regulatory Cells in Human Autoimmunity: More Than a Numbers Game

(2011) S. A. Long et al.   JOURNAL OF IMMUNOLOGY

Increased Frequency of Regulatory T Cells Accompanies Increased Immune Activation in Rectal Mucosae of HIV-Positive Noncontrollers

(2011) J. M. Shaw et al.   JOURNAL OF VIROLOGY

Protective HIV-specific CD8+ T cells evade Treg cell suppression

(2011) Shokrollah Elahi et al.   NATURE MEDICINE

A Low T Regulatory Cell Response May Contribute to Both Viral Control and Generalized Immune Activation in HIV Controllers

(2011) Peter W. Hunt et al.   PLoS One

Frequency of Circulating Regulatory T Cells Increases during Chronic HIV Infection and Is Largely Controlled by Highly Active Antiretroviral Therapy

(2011) Pietro Presicce et al.   PLoS One

CD39/Adenosine Pathway Is Involved in AIDS Progression

(2011) Maria Nikolova et al.   PLoS Pathogens

HIV+ elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses

(2010) Rachel E Owen et al.   AIDS

Increased Turnover of FoxP3high Regulatory T Cells Is Associated With Hyperactivation and Disease Progression of Chronic HIV-1 Infection

(2010) Shaojun Xing et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Human immunodeficiency virus type 1 clade B and C Tat differentially induce indoleamine 2,3-dioxygenase and serotonin in immature dendritic cells: Implications for neuroAIDS

(2010) Thangavel Samikkannu et al.   JOURNAL OF NEUROVIROLOGY

Comprehensive Analysis of Frequency and Phenotype of T Regulatory Cells in HIV Infection: CD39 Expression of FoxP3+ T Regulatory Cells Correlates with Progressive Disease

(2010) J. Schulze zur Wiesch et al.   JOURNAL OF VIROLOGY

Gut Mucosal FOXP3+ Regulatory CD4+ T Cells and Nonregulatory CD4+ T Cells Are Differentially Affected by Simian Immunodeficiency Virus Infection in Rhesus Macaques

(2010) K. Allers et al.   JOURNAL OF VIROLOGY

Increased Sensitivity of CD4+ T-Effector Cells to CD4+CD25+ Treg Suppression Compensates for Reduced Treg Number in Asymptomatic HIV-1 Infection

(2010) Georgina Thorborn et al.   PLoS One

CD4+ T Cell Depletion, Immune Activation and Increased Production of Regulatory T Cells in the Thymus of HIV-Infected Individuals

(2010) Alessandra Bandera et al.   PLoS One

FOXP3 Expression Is Upregulated in CD4+T Cells in Progressive HIV-1 Infection and Is a Marker of Disease Severity

(2010) Melinda S. Suchard et al.   PLoS One

Conversion of Th2 memory cells into Foxp3+ regulatory T cells suppressing Th2-mediated allergic asthma

(2010) B.-S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells

(2009) C. Becker et al.   BLOOD

Regulatory T cells differentially modulate the maturation and apoptosis of human CD8+T-cell subsets

(2009) Maria Nikolova et al.   BLOOD

CTLA‐4 is required by CD4+CD25+Treg to control CD4+T‐cell lymphopenia‐induced proliferation

(2009) Dorothy K. Sojka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

(2009) Maria A. Curotto de Lafaille et al.   IMMUNITY

HIV-1 binding to CD4 on CD4+CD25+ regulatory T cells enhances their suppressive function and induces them to home to, and accumulate in, peripheral and mucosal lymphoid tissues: an additional mechanism of immunosuppression

(2009) J. Ji et al.   INTERNATIONAL IMMUNOLOGY

CD4+ and CD8+ T Cells Expressing FoxP3 in HIV-Infected Patients Are Phenotypically Distinct and Influenced by Disease Severity and Antiretroviral Therapy

(2009) Andrew Lim et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Neuromodulatory Activities of CD4+CD25+ Regulatory T Cells in a Murine Model of HIV-1-Associated Neurodegeneration

(2009) J. Liu et al.   JOURNAL OF IMMUNOLOGY

Decreased Immune Activation in Resistance to HIV‐1 Infection Is Associated with an Elevated Frequency of CD4+CD25+FOXP3+Regulatory T Cells

(2009) Catherine M. Card et al.   JOURNAL OF INFECTIOUS DISEASES

Human Regulatory T Cells Are Targets for Human Immunodeficiency Virus (HIV) Infection, and Their Susceptibility Differs Depending on the HIV Type 1 Strain

(2009) M. E. Moreno-Fernandez et al.   JOURNAL OF VIROLOGY

GARP (LRRC32) is essential for the surface expression of latent TGF-  on platelets and activated FOXP3+ regulatory T cells

(2009) D. Q. Tran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells

(2009) R. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-specific regulatory T cells are associated with higher CD4 cell counts in primary infection

(2008) Hassen Kared et al.   AIDS

FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/- C-/- mice in vivo

(2008) Q. Jiang et al.   BLOOD

CD4+CD25+ Treg cells inhibit human memory    T cells to produce IFN-  in response to M tuberculosis antigen ESAT-6

(2008) L. Li et al.   BLOOD

PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: Restricted expression of type I interferon receptor by CCR5-expressing leukocytes

(2008) Adriano Boasso et al.   CLINICAL IMMUNOLOGY

High frequency and proliferation of CD4+FOXP3+ Treg in HIV-1-infected patients with low CD4 counts

(2008) Xiuqiong Bi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The critical contribution of TGF-β to the induction of Foxp3 expression and regulatory T cell function

(2008) Ethan M. Shevach et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase–dependent mechanism

(2008) Olivier Manches et al.   JOURNAL OF CLINICAL INVESTIGATION

Preservation of FoxP3+ Regulatory T Cells in the Peripheral Blood of Human Immunodeficiency Virus Type 1-Infected Elite Suppressors Correlates with Low CD4+ T-Cell Activation

(2008) A. J. Chase et al.   JOURNAL OF VIROLOGY

Resting Regulatory CD4 T Cells: A Site of HIV Persistence in Patients on Long-Term Effective Antiretroviral Therapy

(2008) Tu-Anh Tran et al.   PLoS One