Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance

CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance

(2013) Chang-An Guo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Origins and Drivers of Insulin Resistance

(2013) Andrew M.F. Johnson et al.   CELL

The Complement Anaphylatoxin C5a Receptor Contributes to Obese Adipose Tissue Inflammation and Insulin Resistance

(2013) J. Phieler et al.   JOURNAL OF IMMUNOLOGY

Lymphocytes in obesity-related adipose tissue inflammation

(2012) A. Chatzigeorgiou et al.   DIABETOLOGIA

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

CD40L Deficiency Ameliorates Adipose Tissue Inflammation and Metabolic Manifestations of Obesity in Mice

(2011) Marjorie Poggi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Binding of CD40L to Mac-1's I-Domain Involves the EQLKKSKTL Motif and Mediates Leukocyte Recruitment and Atherosclerosis—But Does Not Affect Immunity and Thrombosis in Mice

(2011) Dennis Wolf et al.   CIRCULATION RESEARCH

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

Fat-Induced Inflammation Unchecked

(2010) Olivia Osborn et al.   Cell Metabolism

Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile

(2010) Esther Lutgens et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD40L induces inflammation and adipogenesis in adipose cells – a potential link between metabolic and cardiovascular disease

(2010) Isabel Platzer et al.   THROMBOSIS AND HAEMOSTASIS

The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes

(2009) M. Poggi et al.   DIABETOLOGIA

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

The immunobiology of CD154–CD40–TRAF interactions in atherosclerosis

(2009) David Engel et al.   SEMINARS IN IMMUNOLOGY

The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling

(2008) M. M. P. C. Donners et al.   BLOOD