Adaptive immunity in atherogenesis: new insights and therapeutic approaches

Immune Regulatory Function of B Cells

(2012) Claudia Mauri et al.   Annual Review of Immunology

BAFF Receptor Deficiency Reduces the Development of Atherosclerosis in Mice—Brief Report

(2012) Andrew P. Sage et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulatory T-Cell Response to Apolipoprotein B100–Derived Peptides Reduces the Development and Progression of Atherosclerosis in Mice

(2012) Olivier Herbin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice

(2012) Fumitake Usui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of Interleukin-1β Inhibition With Canakinumab on Hemoglobin A1c, Lipids, C-Reactive Protein, Interleukin-6, and Fibrinogen

(2012) Paul M Ridker et al.   CIRCULATION

Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis

(2012) Yvonne Döring et al.   CIRCULATION

The IL-17A/IL-17RA Axis Plays a Proatherogenic Role via the Regulation of Aortic Myeloid Cell Recruitment

(2012) Matthew J. Butcher et al.   CIRCULATION RESEARCH

High Levels of Costimulatory Receptors OX40 and 4-1BB Characterize CD4 + CD28 null T Cells in Patients With Acute Coronary Syndrome

(2012) Ingrid E. Dumitriu et al.   CIRCULATION RESEARCH

Targeting T Cell Costimulation to Prevent Atherothrombosis

(2012) Peder S. Olofsson   CIRCULATION RESEARCH

Apolipoprotein B100 autoimmunity and atherosclerosis – disease mechanisms and therapeutic potential

(2012) Jan Nilsson et al.   CURRENT OPINION IN LIPIDOLOGY

Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype

(2012) Larissa Cardilo-Reis et al.   EMBO Molecular Medicine

CD4+LAP+ and CD4+CD25+Foxp3+ Regulatory T Cells Induced by Nasal Oxidized Low-Density Lipoprotein Suppress Effector T Cells Response and Attenuate Atherosclerosis in ApoE−/− Mice

(2012) Yucheng Zhong et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Dynamic T cell–APC interactions sustain chronic inflammation in atherosclerosis

(2012) Ekaterina K. Koltsova et al.   JOURNAL OF CLINICAL INVESTIGATION

Counterregulation Rules in Atherothrombosis⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.

(2012) Peter Libby   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

In Vivo Detection of Oxidation-Specific Epitopes in Atherosclerotic Lesions Using Biocompatible Manganese Molecular Magnetic Imaging Probes

(2012) Karen C. Briley-Saebo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Re-evaluation of the risk for major adverse cardiovascular events in patients treated with anti-IL-12/23 biological agents for chronic plaque psoriasis: a meta-analysis of randomized controlled trials

(2012) T. Tzellos et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

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(2012) Xiao Meng et al.   MOLECULAR MEDICINE

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(2012) Daniel Griffin et al.   MOLECULAR MEDICINE

To Be 17 Again — Anti–Interleukin-17 Treatment for Psoriasis

(2012) Ari Waisman   NEW ENGLAND JOURNAL OF MEDICINE

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

(2012) Kim A. Papp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

(2012) Craig Leonardi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Depletion of B2 but Not B1a B Cells in BAFF Receptor-Deficient ApoE−/− Mice Attenuates Atherosclerosis by Potently Ameliorating Arterial Inflammation

(2012) Tin Kyaw et al.   PLoS One

TAP1-Deficiency Does Not Alter Atherosclerosis Development in Apoe−/− Mice

(2012) Daniel Kolbus et al.   PLoS One

The Infectious Burden in Atherothrombosis

(2012) Antonella Tufano et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

T Cell Costimulatory and Coinhibitory Pathways in Vascular Inflammatory Diseases

(2012) Andrew H. Lichtman   Frontiers in Physiology

Phenotypic and Functional Heterogeneity of Macrophages and Dendritic Cell Subsets in the Healthy and Atherosclerosis-Prone Aorta

(2012) Matthew J. Butcher et al.   Frontiers in Physiology

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

(2011) Paul M Ridker et al.   AMERICAN HEART JOURNAL

Recent Advances on the Role of Cytokines in Atherosclerosis

(2011) Hafid Ait-Oufella et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of Interleukin 17 in Inflammation, Atherosclerosis, and Vascular Function in Apolipoprotein E–Deficient Mice

(2011) Meena S. Madhur et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Impairment of the Programmed Cell Death-1 Pathway Increases Atherosclerotic Lesion Development and Inflammation

(2011) De-xiu Bu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Interleukin-17A Deficiency Accelerates Unstable Atherosclerotic Plaque Formation in Apolipoprotein E-Deficient Mice

(2011) Keiko Danzaki et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Activation of Th17/Th1 and Th1, but not Th17, is associated with the acute cardiac event in patients with acute coronary syndrome

(2011) Zhao Zhao et al.   ATHEROSCLEROSIS

Inhibition of IL-17A in atherosclerosis

(2011) Xiang Cheng et al.   ATHEROSCLEROSIS

Oxidized phospholipids on apoB-100-containing lipoproteins: a biomarker predicting cardiovascular disease and cardiovascular events

(2011) Adam Taleb et al.   Biomarkers in Medicine

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Dynamic Changes in Regulatory T Cells Are Linked to Levels of Diet-Induced Hypercholesterolemia

(2011) Elena Maganto-García et al.   CIRCULATION

Immunotherapy With Tolerogenic Apolipoprotein B-100–Loaded Dendritic Cells Attenuates Atherosclerosis in Hypercholesterolemic Mice

(2011) Andreas Hermansson et al.   CIRCULATION

B1a B Lymphocytes Are Atheroprotective by Secreting Natural IgM That Increases IgM Deposits and Reduces Necrotic Cores in Atherosclerotic Lesions

(2011) Tin Kyaw et al.   CIRCULATION RESEARCH

Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity

(2011) Yury I. Miller et al.   CIRCULATION RESEARCH

B-Cell Aortic Homing and Atheroprotection Depend on Id3

(2011) Amanda C. Doran et al.   CIRCULATION RESEARCH

Mechanisms for the anti-inflammatory effects of statins

(2011) De-xiu Bu et al.   CURRENT OPINION IN LIPIDOLOGY

Caveolin-1 deficiency decreases atherosclerosis by hampering leukocyte influx into the arterial wall and generating a regulatory T-cell response

(2011) David Engel et al.   FASEB JOURNAL

CD4+CD25highCD127low regulatory T cells in patients with stable angina and their dynamics after intracoronary sirolimus-eluting stent implantation

(2011) Alexandra V. Potekhina et al.   HUMAN IMMUNOLOGY

Association Between Biologic Therapies for Chronic Plaque Psoriasis and Cardiovascular Events

(2011) Caitriona Ryan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Expression of Circulatory Dendritic Cells and Regulatory T-Cells in Patients With Different Subsets of Coronary Artery Disease

(2011) Sieglinde Kofler et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Effect of Oral Atorvastatin on CD4+CD25+ Regulatory T Cells, FoxP3 Expression, and Prognosis in Patients With ST-Segment Elevated Myocardial Infarction Before Primary Percutaneous Coronary Intervention

(2011) Dan Zhang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice

(2011) Christian Weber et al.   JOURNAL OF CLINICAL INVESTIGATION

IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe–/– mice

(2011) Jing Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer Immunotherapy Comes of Age

(2011) Suzanne L. Topalian et al.   JOURNAL OF CLINICAL ONCOLOGY

Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+CD27+CD43+CD70−

(2011) Daniel O. Griffin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

(2011) Rita V. Patel et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Attenuated Atherosclerotic Lesions in apoE-Fc -Chain-Deficient Hyperlipidemic Mouse Model Is Associated with Inhibition of Th17 Cells and Promotion of Regulatory T Cells

(2011) H. P. Ng et al.   JOURNAL OF IMMUNOLOGY

Relationship of IgG and IgM autoantibodies and immune complexes to oxidized LDL with markers of oxidation and inflammation and cardiovascular events: results from the EPIC-Norfolk Study

(2011) Amir Ravandi et al.   JOURNAL OF LIPID RESEARCH

A killer on the road: circulating CD4+CD28null T cells as cardiovascular risk factor in ESRD patients

(2011) Michiel G.H. Betjes et al.   JOURNAL OF NEPHROLOGY

Human Oxidation-Specific Antibodies Reduce Foam Cell Formation and Atherosclerosis Progression

(2011) Sotirios Tsimikas et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

Increased Th17 cells in coronary artery disease are associated with neutrophilic inflammation

(2011) Zikuan Wang et al.   SCANDINAVIAN CARDIOVASCULAR JOURNAL

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Pathogens and atherosclerosis: Update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosis

(2011) Lee Ann Campbell et al.   THROMBOSIS AND HAEMOSTASIS

Cellular immunity, low-density lipoprotein and atherosclerosis: Break of tolerance in the artery wall

(2011) Daniel Ketelhuth et al.   THROMBOSIS AND HAEMOSTASIS

Natural killer T cells in lipoprotein metabolism and atherosclerosis

(2011) Godfrey Getz et al.   THROMBOSIS AND HAEMOSTASIS

The problem of accelerated atherosclerosis in systemic lupus erythematosus: Insights into a complex co-morbidity

(2011) Nekeithia Wade et al.   THROMBOSIS AND HAEMOSTASIS

How dendritic cells shape atherosclerosis

(2011) Ekaterina K Koltsova et al.   TRENDS IN IMMUNOLOGY

Deciphering the role of Th17 cells in human disease

(2011) Cailin Moira Wilke et al.   TRENDS IN IMMUNOLOGY

Cardiovascular disease in rheumatoid arthritis: state of the art and future perspectives

(2010) G. D. Kitas et al.   ANNALS OF THE RHEUMATIC DISEASES

Oxidized Low-Density Lipoprotein and Atherosclerosis

(2010) Daniel Steinberg et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The inhibitory FcγRIIb modulates the inflammatory response and influences atherosclerosis in male apoE−/− mice

(2010) Yanice V. Mendez-Fernandez et al.   ATHEROSCLEROSIS

CD8+ T cell activation predominate early immune responses to hypercholesterolemia in Apoe-/- mice

(2010) Daniel Kolbus et al.   BMC IMMUNOLOGY

Deficiency of Antigen-Presenting Cell Invariant Chain Reduces Atherosclerosis in Mice

(2010) Jiusong Sun et al.   CIRCULATION

CD137 (4–1BB) Deficiency Reduces Atherosclerosis in Hyperlipidemic Mice

(2010) Hyung Jun Jeon et al.   CIRCULATION

Interleukin-17A gene variants and risk of coronary artery disease: A large angiography-based study

(2010) Xiaolin Zhang et al.   CLINICA CHIMICA ACTA

Interleukin-17: friend or foe in atherosclerosis?

(2010) Soraya Taleb et al.   CURRENT OPINION IN LIPIDOLOGY

Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosis

(2010) Andreas Hermansson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B cell depletion reduces the development of atherosclerosis in mice

(2010) Hafid Ait-Oufella et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FcγRIIB Inhibits the Development of Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

(2010) Ming Zhao et al.   JOURNAL OF IMMUNOLOGY

Conventional B2 B Cell Depletion Ameliorates whereas Its Adoptive Transfer Aggravates Atherosclerosis

(2010) T. Kyaw et al.   JOURNAL OF IMMUNOLOGY

IL-17A Is Proatherogenic in High-Fat Diet-Induced and Chlamydia pneumoniae Infection-Accelerated Atherosclerosis in Mice

(2010) S. Chen et al.   JOURNAL OF IMMUNOLOGY

A Critical Function of Th17 Proinflammatory Cells in the Development of Atherosclerotic Plaque in Mice

(2010) Q. Gao et al.   JOURNAL OF IMMUNOLOGY

Complement in atherosclerosis: friend or foe?

(2010) W. S. SPEIDL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice

(2009) T. van Es et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of arterial lesion progression in CD16-deficient mice: evidence for altered immunity and the role of IL-10

(2009) John A. Kelly et al.   CARDIOVASCULAR RESEARCH

Immunoglobulin M Is Required for Protection Against Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

(2009) Myles J. Lewis et al.   CIRCULATION

Interleukin-17 and Interferon-γ Are Produced Concomitantly by Human Coronary Artery–Infiltrating T Cells and Act Synergistically on Vascular Smooth Muscle Cells

(2009) Raymond E. Eid et al.   CIRCULATION

Resident Intimal Dendritic Cells Accumulate Lipid and Contribute to the Initiation of Atherosclerosis

(2009) Kim E. Paulson et al.   CIRCULATION RESEARCH

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

The “atheroprotective” mediators apolipoproteinA-I and Foxp3 are over-abundant in unstable carotid plaques

(2009) S. Patel et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis

(2009) Soraya Taleb et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of IL-17A Attenuates Atherosclerotic Lesion Development in ApoE-Deficient Mice

(2009) C. Erbel et al.   JOURNAL OF IMMUNOLOGY

Innate and adaptive immunity in atherosclerosis

(2009) René R. S. Packard et al.   Seminars in Immunopathology

Vaccination against atherosclerosis? Induction of atheroprotective immunity

(2009) Göran K. Hansson et al.   Seminars in Immunopathology

Interleukin 17: An unlikely marker of acute coronary syndrome?

(2008) K.D. Patel et al.   ATHEROSCLEROSIS

CD137 Is Expressed in Human Atherosclerosis and Promotes Development of Plaque Inflammation in Hypercholesterolemic Mice

(2008) Peder S. Olofsson et al.   CIRCULATION

CD11c + Dendritic Cells Maintain Antigen Processing, Presentation Capabilities, and CD4 + T-Cell Priming Efficacy Under Hypercholesterolemic Conditions Associated With Atherosclerosis

(2008) René R.S. Packard et al.   CIRCULATION RESEARCH

The Th17/Treg imbalance in patients with acute coronary syndrome

(2008) Xiang Cheng et al.   CLINICAL IMMUNOLOGY

The role of adaptive T cell immunity in atherosclerosis: Fig. 1.

(2008) Ziad Mallat et al.   JOURNAL OF LIPID RESEARCH

Contributions of PD-1/PD-L1 pathway to interactions of myeloid DCs with T cells in atherosclerosis

(2008) Jun Lee et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology

The effect of HMG-CoA reductase inhibitors on naturally occurring CD4+CD25+ T cells

(2007) Karin Mausner-Fainberg et al.   ATHEROSCLEROSIS