Journal
DEVELOPMENT
Volume 138, Issue 14, Pages 2895-2902Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.067041
Keywords
Heart regeneration; Heart development; Cardiomyocyte; Epicardium; Zebrafish; Genetic fate-mapping
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Funding
- NHLBI
- AHA
- Pew Charitable Trusts
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Recent lineage-tracing studies have produced conflicting results about whether the epicardium is a source of cardiac muscle cells during heart development. Here, we examined the developmental potential of epicardial tissue in zebrafish during both embryonic development and injury-induced heart regeneration. We found that upstream sequences of the transcription factor gene tcf21 activated robust, epicardium-specific expression throughout development and regeneration. Cre recombinase-based, genetic fate-mapping of larval or adult tcf21(+) cells revealed contributions to perivascular cells, but not cardiomyocytes, during each form of cardiogenesis. Our findings indicate that natural epicardial fates are limited to non-myocardial cell types in zebrafish.
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