Notch signaling in cardiac valve development and disease

Tetralogy of Fallot

(2012) Frederique Bailliard et al.   Orphanet Journal of Rare Diseases

NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT

(2010) Maurisa F. Riley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation

(2010) Luis Luna-Zurita et al.   JOURNAL OF CLINICAL INVESTIGATION

Bicuspid Aortic Valve Disease

(2010) Samuel C. Siu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Common pathogenic features of atherosclerosis and calcific aortic stenosis: role of transforming growth factor-β

(2009) Songyi Xu et al.   CARDIOVASCULAR PATHOLOGY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Tbx20 Interacts With Smads to Confine Tbx2 Expression to the Atrioventricular Canal

(2009) Reena Singh et al.   CIRCULATION RESEARCH

The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage

(2009) Kameswaran Surendran et al.   DEVELOPMENTAL BIOLOGY

Calcific aortic valve disease: outflow obstruction is the end stage of a systemic disease process

(2009) C. M. Otto   EUROPEAN HEART JOURNAL

Notch1 represses osteogenic pathways in aortic valve cells

(2009) Vishal Nigam et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: Role of Smad1 and extracellular signal-regulated kinase 1/2

(2009) Xiaoping Yang et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot

(2009) Steven C Greenway et al.   NATURE GENETICS

Hes1 Is Expressed in the Second Heart Field and Is Required for Outflow Tract Development

(2009) Francesca Rochais et al.   PLoS One

T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgf 2 expression and endocardial cushion formation

(2009) M. Shirai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tricuspid Valve Disease

(2008) Pravin M. Shah et al.   CURRENT PROBLEMS IN CARDIOLOGY

NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling

(2008) K. L. McBride et al.   HUMAN MOLECULAR GENETICS

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

(2008) Kyle Niessen et al.   JOURNAL OF CELL BIOLOGY

The developmental genetics of congenital heart disease

(2008) Benoit G. Bruneau   NATURE

It's T-ALL about Notch

(2008) R M Demarest et al.   ONCOGENE