Characterization of an Environmental DNA-Derived Gene Cluster that Encodes the Bisindolylmaleimide Methylarcyriarubin

The chemistry of isoindole natural products

(2013) Klaus Speck et al.   Beilstein Journal of Organic Chemistry

Discovery and Synthetic Refactoring of Tryptophan Dimer Gene Clusters from the Environment

(2013) Fang-Yuan Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cloning, Characterization and Heterologous Expression of the Indolocarbazole Biosynthetic Gene Cluster from Marine-Derived Streptomyces sanyensis FMA

(2013) Tong Li et al.   Marine Drugs

Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening

(2013) F.-Y. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products

(2013) J. G. Owen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupling Reaction of Indolepyruvic Acid by StaD and Its Product: Implications for Biosynthesis of Indolocarbazole and Violacein

(2012) Shumpei Asamizu et al.   CHEMBIOCHEM

Babysitting Flavin for Biosynthesis

(2012) Shiou-Chuan Tsai   CHEMISTRY & BIOLOGY

An Unusual Role for a Mobile Flavin in StaC-like Indolocarbazole Biosynthetic Enzymes

(2012) Peter J. Goldman et al.   CHEMISTRY & BIOLOGY

mTOR inhibitors in breast cancer: A systematic review

(2012) Flora Zagouri et al.   GYNECOLOGIC ONCOLOGY

Characterization and Functional Modification of StaC and RebC, Which Are Involved in the Pyrrole Oxidation of Indolocarbazole Biosynthesis

(2011) Shumpei ASAMIZU et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Rebeccamycin and Staurosporine Biosynthesis: Insight into the Mechanisms of the Flavin-Dependent Monooxygenases RebC and StaC

(2011) Katherine Groom et al.   CHEMBIOCHEM

Cloning and Characterization of an Environmental DNA-Derived Gene Cluster That Encodes the Biosynthesis of the Antitumor Substance BE-54017

(2011) Fang-Yuan Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine

(2009) Hirofumi Nakano et al.   JOURNAL OF ANTIBIOTICS

Molecular cloning, sequence analysis and functional characterization of the gene cluster for biosynthesis of K-252a and its analogs

(2009) Hsien-Tai Chiu et al.   Molecular BioSystems

Synthesis of Arcyriarubin A and Arcyriaflavin A via Cross-Coupling of Indolylboronic Acid with Dibromomaleimides

(2009) Ke Wang et al.   SYNTHETIC COMMUNICATIONS

Bisindolylmaleimides in anti-cancer therapy - more than PKC inhibitors

(2008) B Pajak et al.   Advances in Medical Sciences

Crystal Structure of VioE, a Key Player in the Construction of the Molecular Skeleton of Violacein

(2008) Satoshi Hirano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Violacein Biosynthetic Enzyme VioE Shares a Fold with Lipoprotein Transporter Proteins

(2008) Katherine S. Ryan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY