Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes

Biosynthesis of the Structurally Unique Polycyclopropanated Polyketide-Nucleoside Hybrid Jawsamycin (FR-900848)

(2014) Tomoshige Hiratsuka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biosynthesis of Streptolidine Involved Two Unexpected Intermediates Produced by a Dihydroxylase and a Cyclase through Unusual Mechanisms

(2014) Chin-Yuan Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biosynthesis of the β-Methylarginine Residue of Peptidyl Nucleoside Arginomycin in Streptomyces arginensis NRRL 15941

(2014) Jun Feng et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Overexpression of ribosome recycling factor is responsible for improvement of nucleotide antibiotic-toyocamycin in Streptomyces diastatochromogenes 1628

(2014) Zheng Ma et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

NRPS Substrate Promiscuity Leads to More Potent Antitubercular Sansanmycin Analogues

(2014) Yunying Xie et al.   JOURNAL OF NATURAL PRODUCTS

Novel nikkomycin analogues generated by mutasynthesis in Streptomyces ansochromogenes

(2014) Chi Feng et al.   Microbial Cell Factories

Structure of theN-glycosidase MilB in complex with hydroxymethyl CMP reveals its Arg23 specifically recognizes the substrate and controls its entry

(2014) Gong Zhao et al.   NUCLEIC ACIDS RESEARCH

Characterization of Biosynthetic Genes of Ascamycin/Dealanylascamycin Featuring a 5′-O-Sulfonamide Moiety in Streptomyces sp. JCM9888

(2014) Chunhua Zhao et al.   PLoS One

Structure-Based Gene Targeting Discovery of Sphaerimicin, a Bacterial Translocase I Inhibitor

(2013) Masanori Funabashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Streptomyces lividans Blasticidin S Deaminase and Its Application in Engineering a Blasticidin S-Producing Strain for Ease of Genetic Manipulation

(2013) Li Li et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Improvement of gougerotin and nikkomycin production by engineering their biosynthetic gene clusters

(2013) Deyao Du et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Cloning, Heterologous Expression, and Characterization of the Gene Cluster Required for Gougerotin Biosynthesis

(2013) Guoqing Niu et al.   CHEMISTRY & BIOLOGY

SsaA, a Member of a Novel Class of Transcriptional Regulators, Controls Sansanmycin Production in Streptomyces sp. Strain SS through a Feedback Mechanism

(2013) Q. Li et al.   JOURNAL OF BACTERIOLOGY

Characterizing Amosamine Biosynthesis in Amicetin Reveals AmiG as a Reversible Retaining Glycosyltransferase

(2013) Ruidong Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Disruption of rimP-SC, encoding a ribosome assembly cofactor, markedly enhances the production of several antibiotics in Streptomyces coelicolor

(2013) Yuanyuan Pan et al.   Microbial Cell Factories

Genetic dissection of the polyoxin building block-carbamoylpolyoxamic acid biosynthesis revealing the “pathway redundancy” in metabolic networks

(2013) Wenqing Chen et al.   Microbial Cell Factories

A two-step sulfation in antibiotic biosynthesis requires a type III polyketide synthase

(2013) Xiaoyu Tang et al.   Nature Chemical Biology

A Practical and Scalable Manufacturing Process for an Antifungal Agent, Nikkomycin Z

(2013) Christopher J. Stenland et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Discovery and Characterization of BlsE, a Radical S-Adenosyl-L-methionine Decarboxylase Involved in the Blasticidin S Biosynthetic Pathway

(2013) Jun Feng et al.   PLoS One

Identification of Mur34 as the Novel Negative Regulator Responsible for the Biosynthesis of Muraymycin in Streptomyces sp. NRRL30471

(2013) Dongmei Xu et al.   PLoS One

Biosynthesis of Albomycin δ2 Provides a Template for Assembling Siderophore and Aminoacyl-tRNA Synthetase Inhibitor Conjugates

(2012) Yu Zeng et al.   ACS Chemical Biology

Characterization of the Amicetin Biosynthesis Gene Cluster from Streptomyces vinaceusdrappus NRRL 2363 Implicates Two Alternative Strategies for Amide Bond Formation

(2012) Gaiyun Zhang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Amalgamation of Nucleosides and Amino Acids in Antibiotic Biosynthesis: Discovery of an l-Threonine:Uridine-5′-Aldehyde Transaldolase

(2012) Sandra Barnard-Britson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering of an industrial polyoxin producer for the rational production of hybrid peptidyl nucleoside antibiotics

(2012) Lipeng Zhai et al.   METABOLIC ENGINEERING

Novel polyoxins generated by heterologously expressing polyoxin biosynthetic gene cluster in the sanN inactivated mutant of Streptomyces ansochromogenes

(2012) Jine Li et al.   Microbial Cell Factories

A stand-alone adenylation domain forms amide bonds in streptothricin biosynthesis

(2012) Chitose Maruyama et al.   Nature Chemical Biology

Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates

(2012) Filip J. Wyszynski et al.   Nature Chemistry

The muraminomicin biosynthetic gene cluster and enzymatic formation of the 2-deoxyaminoribosyl appendage

(2012) Xiuling Chi et al.   MedChemComm

Chemical Logic and Enzymatic Machinery for Biological Assembly of Peptidyl Nucleoside Antibiotics

(2011) Christopher T. Walsh et al.   ACS Chemical Biology

Discovery and Engineered Overproduction of Antimicrobial Nucleoside Antibiotic A201A from the Deep-Sea Marine Actinomycete Marinactinospora thermotolerans SCSIO 00652

(2011) Qinghua Zhu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of LipL as a Non-heme, Fe(II)-dependent α-Ketoglutarate:UMP Dioxygenase That Generates Uridine-5′-aldehyde during A-90289 Biosynthesis

(2011) Zhaoyong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthetic Origin and Mechanism of Formation of the Aminoribosyl Moiety of Peptidyl Nucleoside Antibiotics

(2011) Xiuling Chi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nine Enzymes Are Required for Assembly of the Pacidamycin Group of Peptidyl Nucleoside Antibiotics

(2011) Wenjun Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biogenesis of the Unique 4′,5′-Dehydronucleoside of the Uridyl Peptide Antibiotic Pacidamycin

(2011) Amany E. Ragab et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties

(2011) Jine Li et al.   METABOLIC ENGINEERING

tRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics

(2011) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of a dual specificity aryl acid adenylation enzyme with dual function in nikkomycin biosynthesis

(2010) Mary Moon et al.   BIOPOLYMERS

Pacidamycin Biosynthesis: Identification and Heterologous Expression of the First Uridyl Peptide Antibiotic Gene Cluster

(2010) Emma J. Rackham et al.   CHEMBIOCHEM

Identification of a Napsamycin Biosynthesis Gene Cluster by Genome Mining

(2010) Leonard Kaysser  et al.   CHEMBIOCHEM

Functional and Kinetic Analysis of the Phosphotransferase CapP Conferring Selective Self-resistance to Capuramycin Antibiotics

(2010) Zhaoyong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Arylsulfate Sulfotransferase Involved in Liponucleoside Antibiotic Biosynthesis in Streptomycetes

(2010) Leonard Kaysser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide Screening Reveals the Genetic Determinants of an Antibiotic Insecticide inBacillus thuringiensis

(2010) Xiao-Yan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene Expression Enabling Synthetic Diversification of Natural Products: Chemogenetic Generation of Pacidamycin Analogs

(2010) Abhijeet Deb Roy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cloning, reassembling and integration of the entire nikkomycin biosynthetic gene cluster into Streptomyces ansochromogenes lead to an improved nikkomycin production

(2010) Guojian Liao et al.   Microbial Cell Factories

Identification of the genecluster involved in muraymycin biosynthesis from Streptomyces sp. NRRL 30471

(2010) Lin Cheng et al.   Molecular BioSystems

An ATP-independent strategy for amide bond formation in antibiotic biosynthesis

(2010) Masanori Funabashi et al.   Nature Chemical Biology

Identification of the biosynthetic gene cluster for the pacidamycin group of peptidyl nucleoside antibiotics

(2010) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissecting tunicamycin biosynthesis by genome mining: cloning and heterologous expression of a minimal gene cluster

(2010) Filip J. Wyszynski et al.   Chemical Science

Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis

(2010) Wenqing Chen et al.   Protein & Cell

Characterization of Two Seryl-tRNA Synthetases in Albomycin-Producing Streptomyces sp. Strain ATCC 700974

(2009) Y. Zeng et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Biosynthesis of Liposidomycin-like A-90289 Antibiotics Featuring a New Type of Sulfotransferase

(2009) Masanori Funabashi et al.   CHEMBIOCHEM

Analysis of the Liposidomycin Gene Cluster Leads to the Identification of New Caprazamycin Derivatives

(2009) Leonard Kaysser et al.   CHEMBIOCHEM

Identification of the biosynthetic gene cluster of A-500359s in Streptomyces griseus SANK60196

(2009) Masanori Funabashi et al.   JOURNAL OF ANTIBIOTICS

Characterization of the Polyoxin Biosynthetic Gene Cluster fromStreptomyces cacaoiand Engineered Production of Polyoxin H

(2009) Wenqing Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Manipulation of the Caprazamycin Gene Cluster Lead to New Simplified Liponucleoside Antibiotics and Give Insights into the Biosynthetic Pathway

(2009) Leonard Kaysser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenes

(2009) Guojian Liao et al.   Microbial Cell Factories

polR, a pathway-specific transcriptional regulatory gene, positively controls polyoxin biosynthesis in Streptomyces cacaoi subsp. asoensis

(2009) R. Li et al.   MICROBIOLOGY-SGM

Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure–function studies and nucleoside biosynthesis

(2009) Michael Winn et al.   NATURAL PRODUCT REPORTS

The Mildiomycin Biosynthesis: Initial Steps for Sequential Generation of 5-Hydroxymethylcytidine 5′-Monophosphate and 5-Hydroxymethylcytosine inStreptoverticillium rimofaciensZJU5119

(2008) Li Li et al.   CHEMBIOCHEM

New Pacidamycin Antibiotics Through Precursor-Directed Biosynthesis

(2008) Sabine Grüschow et al.   CHEMBIOCHEM

Unprecedented biological cyclopropanation in the biosynthesis of FR-900848

(2008) Tetsuo Tokiwano et al.   CHEMICAL COMMUNICATIONS

Deciphering Deazapurine Biosynthesis: Pathway for Pyrrolopyrimidine Nucleosides Toyocamycin and Sangivamycin

(2008) Reid M. McCarty et al.   CHEMISTRY & BIOLOGY