Hedgehog Pathway Agonism: Therapeutic Potential and Small-Molecule Development

Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the Smoothened Effector of Signal Response

(2013) Benjamin R. Myers et al.   DEVELOPMENTAL CELL

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

(2013) Daniel Nedelcu et al.   Nature Chemical Biology

Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells

(2013) Yan Liu et al.   Nature Protocols

Recombinant Human Sonic Hedgehog Protein Regulates the Expression of ZO-1 and Occludin by Activating Angiopoietin-1 in Stroke Damage

(2013) Yuan-peng Xia et al.   PLoS One

A review of hedgehog signaling in cranial bone development

(2013) Angel Pan et al.   Frontiers in Physiology

The effect of purmorphamine and sirolimus on osteogenic differentiation of human bone marrow-derived mesenchymal stem cells

(2012) F. Faghihi et al.   BIOMEDICINE & PHARMACOTHERAPY

Potent small molecule Hedgehog agonists induce VEGF expression in vitro

(2012) Katrin Seifert et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel oxysterols activate the Hedgehog pathway and induce osteogenesis

(2012) Frank Stappenbeck et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat

(2012) Raffaele Teperino et al.   CELL

Virtual Ligand-Based Screening Reveals Purmorphamine Analogs with the Capacity to Induce the Osteogenic Differentiation of Human Mesenchymal Stem Cells

(2012) Cecilia Granéli et al.   CELLS TISSUES ORGANS

Glucocorticoid Compounds Modify Smoothened Localization and Hedgehog Pathway Activity

(2012) Yu Wang et al.   CHEMISTRY & BIOLOGY

Molecular Pathways: The Hedgehog Signaling Pathway in Cancer

(2012) R. McMillan et al.   CLINICAL CANCER RESEARCH

Targeting the Hedgehog signaling pathway for cancer therapy

(2012) Yiwei Li et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Oxysterols are allosteric activators of the oncoprotein Smoothened

(2012) Sigrid Nachtergaele et al.   Nature Chemical Biology

Structure–Activity Relationships for Side Chain Oxysterol Agonists of the Hedgehog Signaling Pathway

(2012) Audrey Corman et al.   ACS Medicinal Chemistry Letters

Stepwise Chemically Induced Cardiomyocyte Specification of Human Embryonic Stem Cells

(2011) Rodolfo Gonzalez et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Vitamin D3 Inhibits Hedgehog Signaling and Proliferation in Murine Basal Cell Carcinomas

(2011) J. Y. Tang et al.   Cancer Prevention Research

Hedgehog signaling regulates myelination in the peripheral nervous system through primary cilia

(2011) Kentaro Yoshimura et al.   DIFFERENTIATION

Novel oxysterols have pro-osteogenic and anti-adipogenic effects in vitro and induce spinal fusion in vivo

(2011) Jared S. Johnson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hedgehog signaling and osteoblast gene expression are regulated by purmorphamine in human mesenchymal stem cells

(2011) F.S. Oliveira et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Sonic Hedgehog is Cytoprotective against Oxidative Challenge in a Cellular Model of Amyotrophic Lateral Sclerosis

(2011) Randy Peterson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Self-formation of functional adenohypophysis in three-dimensional culture

(2011) Hidetaka Suga et al.   NATURE

Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen

(2011) S R L Stacpoole et al.   Nature Protocols

Mechanisms and functions of Hedgehog signalling across the metazoa

(2011) Philip W. Ingham et al.   NATURE REVIEWS GENETICS

The Hedgehog Receptor Patched Is Involved in Cholesterol Transport

(2011) Michel Bidet et al.   PLoS One

A Small-Molecule Smoothened Agonist Prevents Glucocorticoid-Induced Neonatal Cerebellar Injury

(2011) V. M. Heine et al.   Science Translational Medicine

Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

(2010) Gerrit J. P. Dijkgraaf et al.   CANCER RESEARCH

Drosophila Genome-wide Obesity Screen Reveals Hedgehog as a Determinant of Brown versus White Adipose Cell Fate

(2010) J. Andrew Pospisilik et al.   CELL

The Hedgehog morphogen in myocardial ischemia–reperfusion injury

(2010) Maarten F Bijlsma et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Sonic Hedgehog signaling in the mammalian brain

(2010) Elisabeth Traiffort et al.   JOURNAL OF NEUROCHEMISTRY

Identification of select glucocorticoids as Smoothened agonists: Potential utility for regenerative medicine

(2010) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potent agonists of the Hedgehog signaling pathway

(2009) Shirley A. Brunton et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Brain-derived neurotrophic factor facilitates maturation of mesenchymal stem cell-derived dopamine progenitors to functional neurons

(2009) Katarzyna A. Trzaska et al.   JOURNAL OF NEUROCHEMISTRY

Differentiation of spinal motor neurons from pluripotent human stem cells

(2009) Bao-Yang Hu et al.   Nature Protocols

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sonic Hedgehog Regulates Ischemia/Hypoxia-Induced Neural Progenitor Proliferation

(2009) John R. Sims et al.   STROKE

Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential

(2008) N. A. Thomas et al.   DEVELOPMENT

Hedgehog Signaling in Mature Osteoblasts Regulates Bone Formation and Resorption by Controlling PTHrP and RANKL Expression

(2008) Kinglun Kingston Mak et al.   DEVELOPMENTAL CELL

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

Wnt and Hedgehog Signaling Pathways in Bone Development

(2008) Timothy F. Day et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Docosahexaenoic acid disruptsin vitroamyloid β1-40fibrillation and concomitantly inhibits amyloid levels in cerebral cortex of Alzheimer’s disease model rats

(2008) Michio Hashimoto et al.   JOURNAL OF NEUROCHEMISTRY

Multiple roles for lipids in the Hedgehog signalling pathway

(2008) Suzanne Eaton   NATURE REVIEWS MOLECULAR CELL BIOLOGY